ChemicalBook >> CAS DataBase List >>MKC3946
MKC3946
- CAS No.
- 1093119-54-0
- Chemical Name:
- MKC3946
- Synonyms
- MKC3946;MKC3946;MKC-3946;MKC 3946;Inositol requiring enzyme 1,inhibit,IRE1,MKC3946,Inhibitor,MKC 3946,MKC-3946;2-Hydroxy-6-(5-(4-methylpiperazine-1-carbonyl)thiophen-2-yl)-1-naphthaldehyde;1-Naphthalenecarboxaldehyde, 2-hydroxy-6-[5-[(4-methyl-1-piperazinyl)carbonyl]-2-thienyl]-
- CBNumber:
- CB03155064
- Molecular Formula:
- C21H20N2O3S
- Molecular Weight:
- 380.46
- MDL Number:
- MOL File:
- 1093119-54-0.mol
Last updated:2024-11-19 23:02:33
| Boiling point | 591.6±50.0 °C(Predicted) |
|---|---|
| Density | 1.337±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO:20.0(Max Conc. mg/mL);52.57(Max Conc. mM) |
| form | A crystalline solid |
| pka | 8.18±0.50(Predicted) |
| color | White to yellow |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
MKC3946 price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19152 | MKC-3946 ≥98% | 1093119-54-0 | 1mg | $56 | 2024-03-01 | Buy |
| Cayman Chemical | 19152 | MKC-3946 ≥98% | 1093119-54-0 | 5mg | $241 | 2024-03-01 | Buy |
| Cayman Chemical | 19152 | MKC-3946 ≥98% | 1093119-54-0 | 10mg | $429 | 2024-03-01 | Buy |
| Cayman Chemical | 19152 | MKC-3946 ≥98% | 1093119-54-0 | 25mg | $936 | 2024-03-01 | Buy |
| ChemScene | CS-6002 | MKC3946 99.68% | 1093119-54-0 | 50mg | $1200 | 2021-12-16 | Buy |
MKC3946 Chemical Properties,Uses,Production
Biological Activity
MKC3946 is a soluble inhibitor of the IRE1α endoribonuclease domain, causing moderate growth inhibition in multiple myeloma cell lines without toxic effects on normal monocytes.
in vivo
In an in vivo model of endoplasmic reticulum stress, MKC-3946 inhibits cleavage of XBP1 and significantly inhibits myeloma cell growth.
target
| Target | Value | ||||
| IRE1α endoribonuclease () |
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38632 | 58 | |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
1093119-54-0(MKC3946)Related Search:
MKC3946
MKC3946;MKC-3946;MKC 3946
1-Naphthalenecarboxaldehyde, 2-hydroxy-6-[5-[(4-methyl-1-piperazinyl)carbonyl]-2-thienyl]-
2-Hydroxy-6-(5-(4-methylpiperazine-1-carbonyl)thiophen-2-yl)-1-naphthaldehyde
Inositol requiring enzyme 1,inhibit,IRE1,MKC3946,Inhibitor,MKC 3946,MKC-3946
1093119-54-0