MK-8998
- CAS No.
- 953778-58-0
- Chemical Name:
- MK-8998
- Synonyms
- MK-8998;CX-8998;CS-2435;Suvecaltamide;MK8998;MK 8998;MK-8998（compound 33）;Suvecaltamide (MK-8998);Suvecaltamide, 10 mM in DMSO;(R)-2-(4-isopropylphenyl)-N-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetaMide;inhibit,MK 8998,Calcium Channel,Ca channels,Inhibitor,Suvecaltamide,Ca2+ channels,MK8998
- CBNumber:
- CB82516066
- Molecular Formula:
- C20H23F3N2O2
- Molecular Weight:
- 380.4
- MDL Number:
- MFCD22572346
- MOL File:
- 953778-58-0.mol
| Boiling point | 510.3±50.0 °C(Predicted) |
|---|---|
| Density | 1.178±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : ≥ 100 mg/mL (262.88 mM);Water : < 0.1 mg/mL (insoluble) |
| form | Solid |
| pka | 14.27±0.46(Predicted) |
| color | White to off-white |
| FDA UNII | MIA4WMP8QN |
MK-8998 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-6198 | MK-8998 99.94% | 953778-58-0 | 5mg | $90 | 2021-12-16 | Buy |
| ChemScene | CS-6198 | MK-8998 99.94% | 953778-58-0 | 10mg | $150 | 2021-12-16 | Buy |
| ChemScene | CS-6198 | MK-8998 99.94% | 953778-58-0 | 50mg | $450 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0027468 | MK-8998 95.00% | 953778-58-0 | 5MG | $496 | 2021-12-16 | Buy |
| ChemScene | CS-6198 | MK-8998 99.94% | 953778-58-0 | 100mg | $700 | 2021-12-16 | Buy |
MK-8998 Chemical Properties,Uses,Production
Uses
Suvecaltamide (MK-8998) is a selective T-type calcium channel inhibitor with oral efficacy. Suvecaltamide exhibits no cytotoxicity in myeloma cell lines and does not affect the antitumor efficacy of Bortezomib (BTZ). Suvecaltamide reverses BTZ-induced peripheral neuropathy (CIPN) in mouse and rat models, and helps inhibit myeloma growth[1].
in vivo
Suvecaltamide (3-30 mg/kg, once daily for 28 days, orally) reverses the peripheral nerve toxicity (CIPN) induced by Bortezomib (BTZ, HY-10227) in a rat model[1].
Suvecaltamide (30 mg/kg, once daily for 28 days, orally) reduces tumor volume in a xenograft mouse model of human multiple myeloma without affecting the anti-cancer activity of BTZ[1].
| Animal Model: | BTZ-Induced CIPN Rat Model[1] |
| Dosage: | 3, 10, 30 mg/kg; once daily for 28 days |
| Administration: | orally |
| Result: | Increased raised the nerve conduction velocity (NCV) levels of the tail nerve and sciatic nerve by dose-dependent. Reduced the β-tubulin polymerization caused by BTZ and increased the number of cutaneous unmyelinated fiber in the hindpaw (IENF) at 30 mg/kg, without affecting proteasome activity. |
| Animal Model: | a START cell-based xenograft athymic nude mouse tumor model of human myeloma[1] |
| Dosage: | 30 mg/kg, once daily for 28 days |
| Administration: | orally |
| Result: | Reduced the size of the tumor without affecting the anti-cancer activity of BTZ or the weight loss effects. |
IC 50
T-type calcium channel
References
[1] Cristina Meregalli, et al. Reversal of Bortezomib-Induced Neurotoxicity by Suvecaltamide, a Selective T-Type Ca-Channel Modulator, in Preclinical Models. Cancers (Basel). 2021 Oct 7;13(19):5013. DOI:10.3390/cancers13195013
MK-8998 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30231 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | 1014988033@qq.com | China | 4966 | 55 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 | |
| Shanghai Hope Chem Co., Ltd.， | +21-18501659228 18501659228 | info@hope-chem.com | China | 480 | 55 |
View Lastest Price from MK-8998 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Suvecaltamide
953778-58-0
|
US $43.00-133.00 / mg | 99.29% | 10g | TargetMol Chemicals Inc. |
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- Suvecaltamide
953778-58-0
- US $43.00-133.00 / mg
- 99.29%
- TargetMol Chemicals Inc.