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4-Methylanisole

4-Methylanisole structure

CAS No.: 104-93-8

Chemical Name:: 4-Methylanisole

Synonyms: MSO;1-METHOXY-4-METHYLBENZENE;P-CRESYL METHYL ETHER;PARA CRESYL METHYL ETHER;P-METHYLANISOLE;4-METHOXYTOLUENE;P-CRESOL METHYL ETHER;Benzene,1-methoxy-4-methyl-;FEMA 2681;MSO)4-Methylan

CBNumber:: CB0327875

Molecular Formula:: C8H10O

Molecular Weight:: 122.16

MDL Number:: MFCD00008413

MOL File:: 104-93-8.mol

Last updated:2025-01-27 09:38:02

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4-Methylanisole Properties

Melting point	-32°C
Boiling point	174 °C(lit.)
Density	0.969 g/mL at 25 °C(lit.)
vapor pressure	5.25 mm Hg ( 50 °C)
refractive index	n20/D 1.511(lit.)
FEMA	2681 \| P-METHYLANISOLE
Flash point	128 °F
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Soluble), Ethyl Acetate (Slightly)
form	Liquid
color	Clear colorless to slightly yellow
Odor	at 1.00 % in dipropylene glycol. naphthyl cresol ylang powdery nutty
Odor Type	naphthyl
biological source	synthetic
explosive limit	1.1-8.3%(V)
Odor Threshold	0.0012ppm
Water Solubility	slightly soluble
λmax	279nm(MeOH)(lit.)
JECFA Number	1243
BRN	1237336
Dielectric constant	4.0300000000000002
Stability	Stable. Incompatible with strong oxidizing agents. Combustible.
LogP	2.74-2.8 at 25-35℃
Substances Added to Food (formerly EAFUS)	P-METHYLANISOLE
CAS DataBase Reference	104-93-8(CAS DataBase Reference)
FDA UNII	10FAI0OR9W
NIST Chemistry Reference	Benzene, 1-methoxy-4-methyl-(104-93-8)
EPA Substance Registry System	p-Methylanisole (104-93-8)
UNSPSC Code	12352200
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS07,GHS08

Signal word

Warning

Hazard statements

H226-H302-H315-H361-H412

Precautionary statements

P202-P210-P273-P301+P312-P303+P361+P353-P308+P313

Hazard Codes

Risk Statements

22-38-10-52/53-63

Safety Statements

36/37-16-61

RIDADR

UN 1993 3/PG 3

WGK Germany

RTECS

BZ8780000

TSCA

Yes

HazardClass

PackingGroup

III

HS Code

29093090

Hazardous Substances Data

104-93-8(Hazardous Substances Data)

Toxicity

The acute oral LD₅₀ in rats was reported as 1.92 (1.51-2.45) g/kg (Hart, 1971). The acute dermal LD₅₀ in rabbits was reported as > 5 g/kg (Hart, 1971).

NFPA 704

	2
0		0

4-Methylanisole price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	148091	4-Methylanisole 99%	104-93-8	100ml	$25.5	2024-03-01	Buy
Sigma-Aldrich	148091	4-Methylanisole 99%	104-93-8	1l	$157	2024-03-01	Buy
TCI Chemical	M0149	4-Methoxytoluene >98.0%(GC)	104-93-8	25mL	$18	2024-03-01	Buy
TCI Chemical	M0149	4-Methoxytoluene >98.0%(GC)	104-93-8	100mL	$28	2024-03-01	Buy
Alfa Aesar	A11572	4-Methylanisole, 99%	104-93-8	500ml	$63.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
148091	100ml	$25.5	Buy
148091	1l	$157	Buy
M0149	25mL	$18	Buy
M0149	100mL	$28	Buy
A11572	500ml	$63.65	Buy

4-Methylanisole Chemical Properties,Uses,Production

Description

p-Methylanisole has a pungent odor suggestive of ylang-ylang. May be prepared by methylation of p-cresol.

Chemical Properties

p-Methylanisole has a pungent odor suggestive of ylang-ylang.

Chemical Properties

colourless liquid

Occurrence

Reported found in the oils of ylang-ylang, cananga and flowers of Mimusops elengi L. Also reported found in tomato, blue and Camembert cheese, starfruit, buckwheat, rooibus tea (Aspalathus linearis) and tapereba (Spondias lutea).

Uses

4-Methylanisole may be used as an analytical standard for the determination of the analyte in Malus taxa flowers, coffee brews, aqueous matrices, food products, and Ficus semicordata by various chromatography techniques.

Uses

4-Methylanisole was used to prepare 5-methoxy-1,8-dimethyltetralin. It was also used as the solubilizate molecule to study the site of incorporation of solubilizates in sodium dodecyl sulfate (SDS) micellar systems.

Uses

Perfumery, flavoring.

Definition

ChEBI: 1-Methoxy-4-methylbenzene is a member of methoxybenzenes.

Preparation

By methylation of p-cresol.

Aroma threshold values

Detection: 200 ppb

Taste threshold values

Taste characteristics at 20 ppm: naphthyl, phenolic, camphoraceous, cooling and woody.

Synthesis Reference(s)

Journal of the American Chemical Society, 113, p. 8516, 1991 DOI: 10.1021/ja00022a046
Tetrahedron Letters, 32, p. 2759, 1991 DOI: 10.1016/0040-4039(91)85078-J
The Journal of Organic Chemistry, 59, p. 4687, 1994 DOI: 10.1021/jo00095a054

General Description

4-Methylanisole is an odorant benzenoid belonging to the group of volatile organic compounds (VOCs). It can contribute to the floral scent of the plants. 4-Methylanisole is typically a lignin-derived bio-oil that is also a major ingredient of certain food products.

Safety Profile

Moderately toxic by ingestion. A skin irritant. Flammable liquid when exposed to heat, sparks, or flame. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

Dissolve 4-methyl anisole in diethyl ether, wash it with M NaOH, water, dry (Na2CO3), evaporate and distil it under vacuum. The picrate has m 103o (from aqueous EtOH). [Beilstein 6 IV 2098.]

4-Methylanisole synthesis

Synthesis of 4-Methylanisole from p-Cresol and Dimethyl carbonate

4-Methylanisole Preparation Products And Raw materials

Raw materials

p-Cresol 2-Methylanisole Benzene, 1,1'-[thiobis(methylene)]bis[4-methoxy- TRIBUTYL(4-METHOXYPHENYL)STANNANE 4-METHOXYBENZYL MERCAPTAN

TETRAMETHYLTIN Sodium methyl sulfate 4-Methoxybenzyl alcohol 4-Methoxybenzyl cyanide Benzoic acid, 4-broMo-, phenyl ester

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Preparation Products

Acid Orange 156 2-Methoxy-5-methylaniline VESNARINONE p-Anisaldehyde Benzene, 1-methyl-4-(1-methylethoxy)-

trinitromethane P-ANISALDEHYDE DIMETHYL ACETAL

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4-Methylanisole Suppliers

Global( 472)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Yanxi Chemical Co., Ltd.	+8617531153977	allison@yan-xi.com	China	5855	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5887	58
airuikechemical co., ltd.	+86-18353166132 +86-18353166132	sales02@airuikechemical.com	China	983	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883 +86-16264648883	niki@zlchemi.com	China	3712	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18949	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21632	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1803	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32965	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29871	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2930	58

Supplier	Advantage
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Chuanghai Biotechnology Co,.LTD	58
airuikechemical co., ltd.	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58

View Lastest Price from 4-Methylanisole manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-02-14	4-Methylanisole 104-93-8	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mujin Biotechnology Co.,Ltd
2025-02-14	4-Methylanisole 104-93-8	US $55.00 / kg	1kg	99%	20 tons	Hebei Zhuanglai Chemical Trading Co Ltd
2024-12-24	4-methylanisole 104-93-8	US $0.00-0.00 / Kg	1Kg	99.99%	200tons	airuikechemical co., ltd.

4-Methylanisole
104-93-8
US $0.00 / KG
99%
Hebei Mujin Biotechnology Co.,Ltd

4-Methylanisole
104-93-8
US $55.00 / kg
99%
Hebei Zhuanglai Chemical Trading Co Ltd

4-methylanisole
104-93-8
US $0.00-0.00 / Kg
99.99%
airuikechemical co., ltd.

4-Methylanisole Spectrum

4-Methylanisole(104-93-8)MS 4-Methylanisole(104-93-8)¹HNMR 4-Methylanisole(104-93-8)¹³CNMR 4-Methylanisole(104-93-8)IR1 4-Methylanisole(104-93-8)IR2 4-Methylanisole(104-93-8)Raman

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FEMA 2681 METHYL-P-CRESOL METHYL P-TOLYL ETHER 4-METHYLANISOLE P-METHYL TOLYL ETHER P-METHOXYTOLUENE 1-methoxy-4-methyl-benzen 1-Methyl-4-methoxybenzene 4-METHYLANISOLE 99+% FCC 4-Methoxytoluol KRESOLMETHYLETHER-PARA 1-METHOXY-4-METHYLBENZENE AKA ( 4-METHYLANISOLE ) 4-METHYLANISOLE 99% 32) PARA CRESYL METHYL ETHER methylphenoxide 4-Methylanisole,99% p-Cresyl methyl eth 4-Methylanisole, 99% 250GR 4-Methylanisole, 99% 5GR 4-Cresolmethylether 4-methoxy-toluen 4-Methyl-1-methoxybenzene 4-methylmethoxybenzene 4-Methylphenol methyl ether 4-methylphenolmethylether 4-METHYLANISOLE FOR SYNTHESIS p-Cresol Methyl Ether 4-Methylanisole 4-Methylanisole (MSO) MSO)4-Methylan Anisole, p-methyl- femanumber2681 methoxy-1methyl-4benzene Methyl 4-methylphenyl ether Methyl p-cresyl ether Methyl p-methylphenyl ether methyl-para-cresol methylpara-cresol para-methoxytoluene para-methyl anisol para-methylanisole p-Methylanisol p-methyl-anisol p-Tolyl methyl ether p-tolylmethylether 4-Methylanizole METH PARA CRESOL 4-Methoxytoluene> Moxifloxacin Imp.Y 4-Methylanisole USP/EP/BP Para Cresyl Methyl Ether (PCME) p-Cresyl methyl ether (kosher) 1-METHOXY-4-METHYLBENZENE 4-METHOXYTOLUENE MSO P-CRESYL METHYL ETHER P-CRESOL METHYL ETHER PARA CRESYL METHYL ETHER P-METHYLANISOLE