| Identification | More | [Name]
4-Methylanisole | [CAS]
104-93-8 | [Synonyms]
1-METHOXY-4-METHYLBENZENE
4-METHOXYTOLUENE
4-METHYLANISOLE
FEMA 2681
METHYL-P-CRESOL
METHYL P-TOLYL ETHER
MSO
PARA CRESYL METHYL ETHER
P-CRESOL METHYL ETHER
P-CRESYL METHYL ETHER
P-METHOXYTOLUENE
P-METHYLANISOLE
P-METHYL TOLYL ETHER
1-methoxy-4-methyl-benzen
1-Methyl-4-methoxybenzene
4-Cresolmethylether
4-methoxy-toluen
4-Methyl-1-methoxybenzene
4-methylmethoxybenzene
4-Methylphenol methyl ether | [EINECS(EC#)]
203-253-7 | [Molecular Formula]
C8H10O | [MDL Number]
MFCD00008413 | [Molecular Weight]
122.16 | [MOL File]
104-93-8.mol |
| Chemical Properties | Back Directory | [Appearance]
colourless liquid | [Melting point ]
-32°C | [Boiling point ]
174 °C(lit.)
| [density ]
0.969 g/mL at 25 °C(lit.)
| [vapor pressure ]
5.25 mm Hg ( 50 °C)
| [FEMA ]
2681 | [refractive index ]
n20/D 1.511(lit.)
| [Fp ]
128 °F
| [storage temp. ]
Flammables area | [solubility ]
Chloroform (Soluble), Ethyl Acetate (Slightly) | [form ]
Liquid | [color ]
Clear colorless to slightly yellow | [Odor]
at 1.00 % in dipropylene glycol. naphthyl cresol ylang powdery nutty | [Stability:]
Stable. Incompatible with strong oxidizing agents. Combustible. | [explosive limit]
1.1-8.3%(V) | [Odor Threshold]
0.0012ppm | [Odor Type]
naphthyl | [Water Solubility ]
slightly soluble | [λmax]
279nm(MeOH)(lit.) | [JECFA Number]
1243 | [BRN ]
1237336 | [Dielectric constant]
4.0300000000000002 | [LogP]
2.74-2.8 at 25-35℃ | [Uses]
Perfumery, flavoring. | [CAS DataBase Reference]
104-93-8(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzene, 1-methoxy-4-methyl-(104-93-8) | [EPA Substance Registry System]
104-93-8(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed.
R38:Irritating to the skin.
R10:Flammable. | [Safety Statements ]
S36/37:Wear suitable protective clothing and gloves .
S16:Keep away from sources of ignition-No smoking . | [RIDADR ]
UN 1993 3/PG 3
| [WGK Germany ]
1
| [RTECS ]
BZ8780000
| [TSCA ]
Yes | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29093090 | [Safety Profile]
Moderately toxic by
ingestion. A skin irritant. Flammable liquid
when exposed to heat, sparks, or flame.
When heated to decomposition it emits
acrid smoke and irritating fumes. | [Hazardous Substances Data]
104-93-8(Hazardous Substances Data) | [Toxicity]
The acute oral LD50 in rats was reported as 1.92 (1.51-2.45) g/kg (Hart, 1971). The acute dermal LD50 in rabbits was reported as > 5 g/kg (Hart, 1971). |
| Hazard Information | Back Directory | [Description]
p-Methylanisole has a pungent odor suggestive of ylang-ylang.
May be prepared by methylation of p-cresol. | [Chemical Properties]
colourless liquid | [Chemical Properties]
p-Methylanisole has a pungent odor suggestive of ylang-ylang. | [Occurrence]
Reported found in the oils of ylang-ylang, cananga and flowers of Mimusops elengi L. Also reported found in
tomato, blue and Camembert cheese, starfruit, buckwheat, rooibus tea (Aspalathus linearis) and tapereba (Spondias lutea). | [Definition]
ChEBI:1-Methoxy-4-methylbenzene is a member of methoxybenzenes. | [Preparation]
By methylation of p-cresol. | [Aroma threshold values]
Detection: 200 ppb | [Taste threshold values]
Taste characteristics at 20 ppm: naphthyl, phenolic, camphoraceous, cooling and woody. | [Synthesis Reference(s)]
Journal of the American Chemical Society, 113, p. 8516, 1991 DOI: 10.1021/ja00022a046
Tetrahedron Letters, 32, p. 2759, 1991 DOI: 10.1016/0040-4039(91)85078-J
The Journal of Organic Chemistry, 59, p. 4687, 1994 DOI: 10.1021/jo00095a054 | [General Description]
4-Methylanisole is an odorant benzenoid belonging to the group of volatile organic compounds (VOCs). It can contribute to the floral scent of the plants. 4-Methylanisole is typically a lignin-derived bio-oil that is also a major ingredient of certain food products. | [Purification Methods]
Dissolve 4-methyl anisole in diethyl ether, wash it with M NaOH, water, dry (Na2CO3), evaporate and distil it under vacuum. The picrate has m 103o (from aqueous EtOH). [Beilstein 6 IV 2098.] |
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