7-Keto-dehydroepiandrosterone
- CAS No.
- 566-19-8
- Chemical Name:
- 7-Keto-dehydroepiandrosterone
- Synonyms
- 7-Oxo-DHEA;7-KETO DHEA;7-KETO DHEA, HPLC 98%;ABiraterone Impurity I;7-keto DHEA(7-Oxo DHEA);Ketodehydroepiandrosterone;7-keto DHEA Acetate Powder;7-Oxo-dehydroepiandrosterone;5-Androsten-3β-ol-7,17-dione;Androst-5-en-3-ol-7,17-dione
- CBNumber:
- CB0329495
- Molecular Formula:
- C19H26O3
- Molecular Weight:
- 302.41
- MDL Number:
- MFCD00198500
- MOL File:
- 566-19-8.mol
- MSDS File:
- SDS
| Melting point | 245-248 °C |
|---|---|
| Boiling point | 477.1±45.0 °C(Predicted) |
| Density | 1.19±0.1 g/cm3(Predicted) |
| solubility | DMF: 25 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 15 mg/ml; Ethanol: 10 mg/ml |
| form | A crystalline solid |
| pka | 14.67±0.60(Predicted) |
| InChI | InChI=1/C19H26O3/c1-18-7-5-12(20)9-11(18)10-15(21)17-13-3-4-16(22)19(13,2)8-6-14(17)18/h10,12-14,17,20H,3-9H2,1-2H3/t12-,13-,14-,17-,18-,19-/s3 |
| InChIKey | KPRGOTLNGIBVFL-YQJRJXGQNA-N |
| SMILES | C[C@]12CC[C@H](O)CC1=CC(=O)[C@@]1([H])[C@]3([H])CCC(=O)[C@@]3(C)CC[C@]21[H] |&1:1,4,11,13,19,23,r| |
| CAS DataBase Reference | 566-19-8(CAS DataBase Reference) |
| FDA UNII | 2334LJD2E9 |
7-Keto-dehydroepiandrosterone price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22497 | 7-keto Dehydroepiandrosterone ≥98% | 566-19-8 | 5mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 22497 | 7-keto Dehydroepiandrosterone ≥98% | 566-19-8 | 10mg | $78 | 2024-03-01 | Buy |
| IsoSciences | 13390 | Ketodehydroepiandrosterone ≥98% | 566-19-8 | 1mg | $45 | 2021-12-16 | Buy |
| Matrix Scientific | 147683 | (3S,8R,9S,10R,13S,14S)-3-Hydroxy-10,13-dimethyl-3,4,9,10,11,12,13,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-7,17(2H,8H)-dione 95% | 566-19-8 | 25g | $78 | 2021-12-16 | Buy |
| Matrix Scientific | 147683 | (3S,8R,9S,10R,13S,14S)-3-Hydroxy-10,13-dimethyl-3,4,9,10,11,12,13,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-7,17(2H,8H)-dione 95% | 566-19-8 | 100g | $260 | 2021-12-16 | Buy |
7-Keto-dehydroepiandrosterone Chemical Properties,Uses,Production
Regulation
The FDA has proposed that 7-Keto-DHEA be included among substances banned from use in compounded drugs.
Description
7-Ketodehydroepiandrosterone (7-Keto-dehydroepiandrosterone; 7-keto-DHEA), chemically known under 3-acetyl-7-oxo-dehydroepiandrosterone, is a naturally occurring metabolite of the steroid hormone dehydroepiandrosterone (DHEA) and is marketed as such an anti-obesity dietary supplement. The synthesis of 7-keto-DHEA begins with an irreversible hydroxylation of DHEA in the position C7 by cytochrome P450 7B1 (CYP7B1) under the formation of 7 α-hydroxy-dehydroepiandrosterone (7 α-OH-DHEA). β-hydroxysteroid dehydrogenase type 1 (11 β-HSD 1) then catalyzes the interconversion of 7 α-OH-DHEA and 7 β-hydroxy-dehydroepiandrosterone (7 β-OH-DHEA) through a 7-keto-DHEA intermediary. DHEA is a "parent hormone" produced by glands near the kidneys. However, unlike DHEA, 7-keto-DHEA is not converted to steroid hormones such as androgen and estrogen. Taking 7-keto-DHEA by mouth or applying it to the skin does not increase the level of steroid hormones in the blood. People take 7-keto-DHEA for obesity, muscle strength, anxiety, depression, and other conditions. However, there is no good scientific evidence to support these uses[1].
Uses
7-Keto Dehydro Epiandrosterone-d6 is the isotope labelled analog of 7-Keto Dehydro Epiandrosterone (K187700); a metabolite of Dehydroepiandrosterone (DHEA) (D229585) which is the major secretory steroidal product of the adrenal gland.
Definition
ChEBI: 7-ketodehydroepiandrosterone is a 3beta-hydroxy-Delta(5)-steroid that is dehydroepiandrosterone carrying an additional oxo group at position 7. It has a role as a human blood serum metabolite, a nutraceutical and a prohormone. It is a 17-oxo steroid, a 3beta-hydroxy-Delta(5)-steroid, an androstanoid and a 7-oxo steroid. It is functionally related to a dehydroepiandrosterone.
Side effects
7-Keto-dehydroepiandrosterone might cause mild side effects such as nausea, dizziness, or low blood pressure in some people.
Physiological effects
In the past ten years, a large number of studies have shown that 7-keto dehydroepiandrosterone has stronger physiological activity than DHEA, especially in anti-aging, enhancing immunity, improving memory, enhancing brain function, preventing Alzheimer’s and diabetes , It has a strong effect on reducing the risk of heart disease, losing weight, increasing bone density and muscle vitality.
References
[1] Nishanthini Jeyaprakash. “A systematic review of the impact of 7-keto-DHEA on body weight.” Archives of Gynecology and Obstetrics 308 3 (2022): 777–785.
7-Keto-dehydroepiandrosterone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Pharmaceuticals Group Corp., Ltd. | +8613004379774 | wu@jiaerke.com | China | 33 | 58 |
| Wuhan Han Sheng New Material Technology Co.，Ltd | +8617798174412 | admin01@hsnm.com.cn | China | 2097 | 58 |
| Wuhan Ruichi Technology Co., Ltd | +8613545065237 | admin@whrchem.com | China | 153 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12837 | 58 |
| Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 | admin@firsky-cn.com | China | 427 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 615 | 58 |
| Shandong Hanjiang Chemical Co., Ltd | +86-0533-2066820 +8618369939125 | hanson@sdhanjiang.com | China | 999 | 58 |
| Shaanxi Franta Biotechnology Co., Ltd | +86-13082019107 +86-13082019107 | admin@flanderff.com | China | 206 | 58 |
| Hebei Kangcang new material Technology Co., LTD | +8615713292910 | Nancy@kangcang.com.cn | China | 341 | 58 |
Related articles
- Why can 7-Keto-dehydroepiandrosterone be used for weight loss?
- 7-Keto-dehydroepiandrosterone (7-keto-DHEA) is a by-product of dehydroepiandrosterone (DHEA), a chemical formed in the body.
- Oct 9，2024
View Lastest Price from 7-Keto-dehydroepiandrosterone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-09-23 | 7-Keto-dehydroepiandrosterone
566-19-8
|
US $200.00 / kg | 1kg | 99% | 1000kg | Shaanxi Franta Biotechnology Co., Ltd | |
 |
2024-09-18 | 7-Keto-dehydroepiandrosterone
566-19-8
|
US $1000.00 / Kg/Bag | 1Kg/Bag | 99% | 1000kg/month | XI'AN TIANGUANGYUAN BIOTECH CO., LTD. | |
 |
2024-07-06 | 7-Keto-Dehydroepiandrosterone
566-19-8
|
US $0.00 / kg | 1kg | 0.99 | 10T | Shandong Hanjiang Chemical Co., Ltd |
-
- 7-Keto-dehydroepiandrosterone
566-19-8
- US $200.00 / kg
- 99%
- Shaanxi Franta Biotechnology Co., Ltd
-
- 7-Keto-dehydroepiandrosterone
566-19-8
- US $1000.00 / Kg/Bag
- 99%
- XI'AN TIANGUANGYUAN BIOTECH CO., LTD.
-
- 7-Keto-Dehydroepiandrosterone
566-19-8
- US $0.00 / kg
- 0.99
- Shandong Hanjiang Chemical Co., Ltd
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