ChemicalBook >> CAS DataBase List >>WRR483
WRR483
- CAS No.
- 1076088-50-0
- Chemical Name:
- WRR483
- Synonyms
- WRR483;1-Piperazinecarboxamide, N-[(1S)-4-[(aminoiminomethyl)amino]-1-[[[(1S)-1-(2-phenylethyl)-3-(phenylsulfonyl)-2-propen-1-yl]amino]carbonyl]butyl]-4-methyl-
- CBNumber:
- CB03335167
- Molecular Formula:
- C29H41N7O4S
- Molecular Weight:
- 583.75
- MDL Number:
- MOL File:
- 1076088-50-0.mol
Last updated:2023-03-31 09:12:58
WRR483 Chemical Properties,Uses,Production
Description
WRR-483, an analogue of K-11777, is a potent and selective cysteine protease inhibitor with trypanocidal activity in cell culture and animal model with comparable efficacy to K11777. WRR-483 demonstrates good potency against cruzain with sensitivity to pH conditions and high efficacy in the cell culture assay. Furthermore, WRR-483 also eradicates parasite infection in a mouse model of acute Chagas' disease. WRR-483 binds covalently to the active site cysteine of the protease in a similar manner as other vinyl sulfone-based inhibitors. WRR-483 has potential to be developed as a treatment for Chagas' disease.
WRR483 Preparation Products And Raw materials
Raw materials
Preparation Products
WRR483 Suppliers
Global( 2)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19696 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
WRR483
1-Piperazinecarboxamide, N-[(1S)-4-[(aminoiminomethyl)amino]-1-[[[(1S)-1-(2-phenylethyl)-3-(phenylsulfonyl)-2-propen-1-yl]amino]carbonyl]butyl]-4-methyl-
1076088-50-0
C29H41N7O4S