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inS3-54A18

CAS No.
328998-53-4
Chemical Name:
inS3-54A18
Synonyms
inS3-54A18;CID 1920398;inS3-54A18, 10 mM in DMSO;inS3-54A18,Inhibitor,inS-3-54A18,inS3 54A18,inS354A18,inhibit,STAT;3-(4-Chlorobenzylidene)-1-(4-hydroxyphenyl)-5-phenyl-1,3-dihydro-2H-pyrrol-2-one;2H-Pyrrol-2-one, 3-[(4-chlorophenyl)methylene]-1,3-dihydro-1-(4-hydroxyphenyl)-5-phenyl-
CBNumber:
CB03356160
Molecular Formula:
C23H16ClNO2
Molecular Weight:
373.83
MDL Number:
MOL File:
328998-53-4.mol
Last updated:2025-04-28 21:36:36

inS3-54A18 Properties

Boiling point 630.5±55.0 °C(Predicted)
Density 1.363±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : ≥ 150 mg/mL (401.25 mM)
form Solid
pka 10.05±0.30(Predicted)
color Yellow to orange

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

inS3-54A18 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-7550 inS3-54A18 99.83% 328998-53-4 2mg $132 2021-12-16 Buy
ChemScene CS-7550 inS3-54A18 99.83% 328998-53-4 5mg $192 2021-12-16 Buy
ChemScene CS-7550 inS3-54A18 99.83% 328998-53-4 10mg $312 2021-12-16 Buy
ChemScene CS-7550 inS3-54A18 99.83% 328998-53-4 50mg $1140 2021-12-16 Buy
ChemScene CS-7550 inS3-54A18 99.83% 328998-53-4 100mg $1920 2021-12-16 Buy
Product number Packaging Price Buy
CS-7550 2mg $132 Buy
CS-7550 5mg $192 Buy
CS-7550 10mg $312 Buy
CS-7550 50mg $1140 Buy
CS-7550 100mg $1920 Buy

inS3-54A18 Chemical Properties,Uses,Production

Uses

inS3-54A18 is a potent STAT3 inhibitor, with anti-cancer properties.

in vivo

inS3-54A18 (200?mg/kg, p.o.) inhibits tumor growth, metastasis and expression of STAT3 target genes in a mouse xenograft model of A549 cells[1].

IC 50

STAT3

References

[1] Huang W, et al. Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo. Oncogene. 2016 Feb 11;35(6):783-92. DOI:10.1038/onc.2015.215
[2] Huang W, et al. Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo. Oncogene. 2016 Feb 11;35(6):783-92

inS3-54A18 Preparation Products And Raw materials

Raw materials

Preparation Products

inS3-54A18 Suppliers

Global( 40)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32222 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
LEAPCHEM CO., LTD.
+86-852-30606658 market18@leapchem.com China 43340 58
Aladdin Scientific
tp@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 131957 58
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4861 58
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 71829 60
Shanghai Rechem science Co., Ltd. 21-31433387 15618786686 sales@rechemscience.com China 2993 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 18892239720 psaitong@jm-bio.com China 12306 58

View Lastest Price from inS3-54A18 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
inS3-54A18 pictures 2025-04-27 inS3-54A18
328998-53-4
US $35.00-94.00 / mg 99.54% 10g TargetMol Chemicals Inc.
  • inS3-54A18 pictures
  • inS3-54A18
    328998-53-4
  • US $35.00-94.00 / mg
  • 99.54%
  • TargetMol Chemicals Inc.

inS3-54A18 Spectrum

inS3-54A18 2H-Pyrrol-2-one, 3-[(4-chlorophenyl)methylene]-1,3-dihydro-1-(4-hydroxyphenyl)-5-phenyl- 3-(4-Chlorobenzylidene)-1-(4-hydroxyphenyl)-5-phenyl-1,3-dihydro-2H-pyrrol-2-one inS3-54A18,Inhibitor,inS-3-54A18,inS3 54A18,inS354A18,inhibit,STAT CID 1920398 inS3-54A18, 10 mM in DMSO 328998-53-4