inS3-54A18
- CAS No.
- 328998-53-4
- Chemical Name:
- inS3-54A18
- Synonyms
- inS3-54A18;CID 1920398;inS3-54A18, 10 mM in DMSO;inS3-54A18,Inhibitor,inS-3-54A18,inS3 54A18,inS354A18,inhibit,STAT;3-(4-Chlorobenzylidene)-1-(4-hydroxyphenyl)-5-phenyl-1,3-dihydro-2H-pyrrol-2-one;2H-Pyrrol-2-one, 3-[(4-chlorophenyl)methylene]-1,3-dihydro-1-(4-hydroxyphenyl)-5-phenyl-
- CBNumber:
- CB03356160
- Molecular Formula:
- C23H16ClNO2
- Molecular Weight:
- 373.83
- MDL Number:
- MOL File:
- 328998-53-4.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
inS3-54A18 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-7550 | inS3-54A18 99.83% | 328998-53-4 | 2mg | $132 | 2021-12-16 | Buy |
| ChemScene | CS-7550 | inS3-54A18 99.83% | 328998-53-4 | 5mg | $192 | 2021-12-16 | Buy |
| ChemScene | CS-7550 | inS3-54A18 99.83% | 328998-53-4 | 10mg | $312 | 2021-12-16 | Buy |
| ChemScene | CS-7550 | inS3-54A18 99.83% | 328998-53-4 | 50mg | $1140 | 2021-12-16 | Buy |
| ChemScene | CS-7550 | inS3-54A18 99.83% | 328998-53-4 | 100mg | $1920 | 2021-12-16 | Buy |
inS3-54A18 Chemical Properties,Uses,Production
Uses
inS3-54A18 is a potent STAT3 inhibitor, with anti-cancer properties.
in vivo
inS3-54A18 (200?mg/kg, p.o.) inhibits tumor growth, metastasis and expression of STAT3 target genes in a mouse xenograft model of A549 cells[1].
IC 50
STAT3
References
[1] Huang W, et al. Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo. Oncogene. 2016 Feb 11;35(6):783-92. DOI:10.1038/onc.2015.215
[2] Huang W, et al. Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo. Oncogene. 2016 Feb 11;35(6):783-92
inS3-54A18 Preparation Products And Raw materials
Raw materials
Preparation Products
inS3-54A18 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32222 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71829 | 60 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2993 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12306 | 58 |
View Lastest Price from inS3-54A18 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-27 | inS3-54A18
328998-53-4
|
US $35.00-94.00 / mg | 99.54% | 10g | TargetMol Chemicals Inc. |
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- inS3-54A18
328998-53-4
- US $35.00-94.00 / mg
- 99.54%
- TargetMol Chemicals Inc.