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ChemicalBook >> CAS DataBase List >>diethyl 4-((6R,8S)-8-methyl-9-oxo-5,6,8,9-tetrahydrothiepino[4,5:4,5]benzo[1,2-d][1,3]dioxole-6-carboxamido)benzylphosphonate

diethyl 4-((6R,8S)-8-methyl-9-oxo-5,6,8,9-tetrahydrothiepino[4,5:4,5]benzo[1,2-d][1,3]dioxole-6-carboxamido)benzylphosphonate

diethyl 4-((6R,8S)-8-methyl-9-oxo-5,6,8,9-tetrahydrothiepino[4,5:4,5]benzo[1,2-d][1,3]dioxole-6-carboxamido)benzylphosphonate Structure
diethyl 4-((6R,8S)-8-methyl-9-oxo-5,6,8,9-tetrahydrothiepino[4,5:4,5]benzo[1,2-d][1,3]dioxole-6-carboxamido)benzylphosphonate structure
CAS No.
180185-61-9
Chemical Name:
diethyl 4-((6R,8S)-8-methyl-9-oxo-5,6,8,9-tetrahydrothiepino[4,5:4,5]benzo[1,2-d][1,3]dioxole-6-carboxamido)benzylphosphonate
Synonyms
diethyl 4-((6R,8S)-8-methyl-9-oxo-5,6,8,9-tetrahydrothiepino[4,5:4,5]benzo[1,2-d][1,3]dioxole-6-carboxamido)benzylphosphonate;Phosphonic acid, P-[[4-[[[(6R,8S)-5,6,8,9-tetrahydro-8-methyl-9-oxothiepino[4,5-f]-1,3-benzodioxol-6-yl]carbonyl]amino]phenyl]methyl]-, diethyl ester
CBNumber:
CB03594469
Molecular Formula:
C24H28NO7PS
Molecular Weight:
505.52
MDL Number:
MFCD00949474
MOL File:
180185-61-9.mol
Last updated:2023-05-21 10:59:17
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diethyl 4-((6R,8S)-8-methyl-9-oxo-5,6,8,9-tetrahydrothiepino[4,5:4,5]benzo[1,2-d][1,3]dioxole-6-carboxamido)benzylphosphonate Properties

Melting point 181-182 °C
Boiling point 742.3±60.0 °C(Predicted)
Density 1.334±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka 13.12±0.70(Predicted)
FDA UNII RJF24P5QDS

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338

diethyl 4-((6R,8S)-8-methyl-9-oxo-5,6,8,9-tetrahydrothiepino[4,5:4,5]benzo[1,2-d][1,3]dioxole-6-carboxamido)benzylphosphonate price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC T004885 TAK778 180185-61-9 10mg $235 2021-12-16 Buy
BLDpharm BD00795021 Tak-778 98% 180185-61-9 5mg $2605 2021-12-16 Buy
Product number Packaging Price Buy
T004885 10mg $235 Buy
BD00795021 5mg $2605 Buy

diethyl 4-((6R,8S)-8-methyl-9-oxo-5,6,8,9-tetrahydrothiepino[4,5:4,5]benzo[1,2-d][1,3]dioxole-6-carboxamido)benzylphosphonate Chemical Properties,Uses,Production

Uses

TAK-778 is a derivative of Ipriflavone and is shown to induce bone growth in vitro and in vivo. Recently, it has been shown that TAK-778 can enhance osteoblast differentiation of human bone marrow cells via an estrogen receptor (ER)-dependent pathway.

diethyl 4-((6R,8S)-8-methyl-9-oxo-5,6,8,9-tetrahydrothiepino[4,5:4,5]benzo[1,2-d][1,3]dioxole-6-carboxamido)benzylphosphonate Preparation Products And Raw materials

Raw materials

Preparation Products

diethyl 4-((6R,8S)-8-methyl-9-oxo-5,6,8,9-tetrahydrothiepino[4,5:4,5]benzo[1,2-d][1,3]dioxole-6-carboxamido)benzylphosphonate Suppliers

Global( 8)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7552 61
Shenzhen Regent Biochemical Technology Co., Ltd. 0755-0755-85201366 18938635012 sales@regentsciences.com China 9356 58
Wuxi AppTec 022-59987777 13552403979 jia_guoqiang@wuxiapptec.com China 22345 58
Beijing xinyanhui pharmaceutical research and development co., LTD 13969155946 1461866103@qq.com China 16111 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 15801484223; psaitong@jm-bio.com China 29774 58
Suzhou Meishi Biotechnology Co., Ltd. 1173954148q meishipharma@126.com China 20033 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Haoyuan Chemexpress Co., Ltd. 61
Shenzhen Regent Biochemical Technology Co., Ltd. 58
Wuxi AppTec 58
Beijing xinyanhui pharmaceutical research and development co., LTD 58
Beijing Jin Ming Biotechnology Co., Ltd. 58
Suzhou Meishi Biotechnology Co., Ltd. 58
Phosphonic acid, P-[[4-[[[(6R,8S)-5,6,8,9-tetrahydro-8-methyl-9-oxothiepino[4,5-f]-1,3-benzodioxol-6-yl]carbonyl]amino]phenyl]methyl]-, diethyl ester diethyl 4-((6R,8S)-8-methyl-9-oxo-5,6,8,9-tetrahydrothiepino[4,5:4,5]benzo[1,2-d][1,3]dioxole-6-carboxamido)benzylphosphonate 180185-61-9 C24H28NO7PS