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Disuccinimidyl glutarate

CAS No.
79642-50-5
Chemical Name:
Disuccinimidyl glutarate
Synonyms
DSG;DG1;CDHF4;DSG Crosslinker;DISUCCINIMIDYL GLUTARATE;DI(N-SUCCINIMIDYL) GLUTARATE;N,N'-Disuccinimidyl Glutarate;Disuccinimidyl Glutarate (>97%);DSG [Di(N-succinimidyl) glutarate;Di(N-hydroxysucciniMidyl) glutarate
CBNumber:
CB0373852
Molecular Formula:
C13H14N2O8
Molecular Weight:
326.26
MDL Number:
MFCD00153597
MOL File:
79642-50-5.mol
MSDS File:
SDS
Last updated:2024-11-19 20:33:22

Disuccinimidyl glutarate Properties

Melting point 168-172 °C
Boiling point 485.1±55.0 °C(Predicted)
Density 1.53±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility Soluble in dimethylsulfoxide and dimethylformamide.
form Solid
color White to Off-White
Water Solubility Partially soluble in water.
Sensitive Moisture Sensitive
BRN 8575145
Stability Hygroscopic, Moisture Sensitive, Unstable in Aqueous Solution
InChI InChI=1S/C13H14N2O8/c16-8-4-5-9(17)14(8)22-12(20)2-1-3-13(21)23-15-10(18)6-7-11(15)19/h1-7H2
InChIKey LNQHREYHFRFJAU-UHFFFAOYSA-N
SMILES C(ON1C(=O)CCC1=O)(=O)CCCC(ON1C(=O)CCC1=O)=O
CAS DataBase Reference 79642-50-5

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
10-21
HS Code  29280000
NFPA 704
1
2 0

Disuccinimidyl glutarate price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 80424 Di(N-succinimidyl) glutarate ≥97.0% (CHN) 79642-50-5 5mg $42.8 2024-03-01 Buy
Sigma-Aldrich 80424 Di(N-succinimidyl) glutarate ≥97.0% (CHN) 79642-50-5 50mg $318 2024-03-01 Buy
Sigma-Aldrich SAB2501785 Anti-DSG1 antibody produced in goat affinity isolated antibody, buffered aqueous solution 79642-50-5 100μG $545 2023-01-07 Buy
Alfa Aesar H58208 Disuccinimidyl glutarate, 97% 79642-50-5 100mg $128 2024-03-01 Buy
Alfa Aesar H58208 Disuccinimidyl glutarate, 97% 79642-50-5 500mg $470 2024-03-01 Buy
Product number Packaging Price Buy
80424 5mg $42.8 Buy
80424 50mg $318 Buy
SAB2501785 100μG $545 Buy
H58208 100mg $128 Buy
H58208 500mg $470 Buy

Disuccinimidyl glutarate Chemical Properties,Uses,Production

Description

Disuccinimidyl glutarate (DSG) is a homobifunctional crosslinking agent that contains amine-reactive N-hydroxysuccinimide (NHS) ester groups at each end. DSG is membrane-permeable and non-cleavable. DSG can be combined with formaldehyde fixation to improve the detection of specific protein-DNA complexes.

Chemical Properties

DSG crosslinker (Disuccinimidyl glutarate; Di(N-succinimidyl) glutarate) is a homobifunctional crosslinking reagent that is membrane permeable. DSG protein crosslinker is often used in ChIP assays to determine DNA-protein binding interactions; using DSG and formaldehyde in a two-step crosslinking strategy greatly improves the ChIP assay. Disuccinimidyl crosslinkers include disuccinimidyl glutarate (DSG), disuccinimidyl suberate (DSS), and bis-N-succinimidyl-(pentaethylene glycol) ester (BS(PEG)5)[1]. DSG crosslinking takes place through amine-reactive NHS esters at both ends of a 5-atom (7.7 angstrom) spacer arm. DSS (crosslinker arm length = 11.4Å), DSG (crosslinker arm length = 7.5Å), and disuccinimidyl tartrate (DST, crosslinker arm length = 5.8Å) are homobifunctional crosslinking reagents that react specifically with primary amines[2]. DSG crosslinker must be dissolved in an organic solvent, such as DMSO or DMF, and then added to an aqueous crosslinking reaction. The directly water-soluble version of Di(N-succinimidyl) glutarate (DSG) is BS2G.

Characteristics

Features of disuccinimidyl glutarate:
Reactive groups: NHS ester (both ends)
Reactive towards: amino groups (primary amines)
Non-cleavable
Water-insoluble (dissolve first in DMF or DMSO)
Membrane-permeable, allowing for intracellular crosslinking
Can increase crosslinking efficiency compared to DSS in some applications

Uses

Disuccinimidyl glutarate is used as a membrane-soluble, amine-reactive N-hydroxysuccinamide ester-based homobifunctional crosslinking reagent. It is a homobifunctionla cross-linking reagent, for ex. isolation of the insulin receptor.

General Description

DSG crosslinker (Disuccinimidyl glutarate; Di(N-succinimidyl) glutarate) is a homobifunctional crosslinking reagent that is membrane permeable. DSG protein crosslinker is often used in ChIP assays to determine DNA-protein binding interactions; using DSG and formaldehyde in a two-step cross-linking strategy greatly improves the ChIP assay.
DSG crosslinking takes place through amine-reactive NHS esters at both ends of a 5-atom (7.7 angstrom) spacer arm. DSG crosslinker must be dissolved in an organic solvent, such as DMSO or DMF, then added to an aqueous crosslinking reaction. The directly water soluble version of Di(N-succinimidyl) glutarate (DSG) is BS2G.

References

[1] JeeYoung Kim, Min Park, Gun Yong Sung. “Efficient Portable Urea Biosensor Based on Urease Immobilized Membrane for Monitoring of Physiological Fluids.” Biomedicines (2020).
[2] Petr Novak. “A top-down approach to protein structure studies using chemical cross-linking and Fourier transform mass spectrometry.” European Journal of Mass Spectrometry 9 6 (2003): 623–31.

6066-82-6
110-94-1
79642-50-5
Synthesis of Disuccinimidyl glutarate from N-Hydroxysuccinimide and Glutaric acid

Disuccinimidyl glutarate Preparation Products And Raw materials

Raw materials

Preparation Products

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Hangzhou Huarong Pharm Co., Ltd.
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View Lastest Price from Disuccinimidyl glutarate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
DSG Crosslinker pictures 2024-11-19 DSG Crosslinker
79642-50-5
US $39.00-89.00 / mg 99.89% 10g TargetMol Chemicals Inc.
bis(2,5-dioxopyrrolidin-1-yl)pentanedioate pictures 2022-01-15 bis(2,5-dioxopyrrolidin-1-yl)pentanedioate
79642-50-5
US $0.00 / KG 1KG 99.2% 100 tons Honest Joy Holdings Limited
DSG Crosslinker pictures 2021-09-16 DSG Crosslinker
79642-50-5
US $0.00-0.00 / g 100mg 99% 100KG Hangzhou Huarong Pharm Co., Ltd.
  • DSG Crosslinker pictures
  • DSG Crosslinker
    79642-50-5
  • US $39.00-89.00 / mg
  • 99.89%
  • TargetMol Chemicals Inc.
  • DSG Crosslinker pictures
  • DSG Crosslinker
    79642-50-5
  • US $0.00-0.00 / g
  • 99%
  • Hangzhou Huarong Pharm Co., Ltd.
DI(N-SUCCINIMIDYL) GLUTARATE DSG DISUCCINIMIDYL GLUTARATE Di(N-hydroxysucciniMidyl) glutarate 2,5-Pyrrolidinedione, 1,1'-[(1,5-dioxo-1,5-pentanediyl)bis(oxy)]bis- Anti-DSG1 antibody produced in goat CDHF4 DG1 DSG Crosslinker bis(2,5-dioxopyrrolidin-1-yl) pentanedioate DSG [Di(N-succinimidyl) glutarate] *CAS 79642-50-5* Pentanedioic acid,1,5-bis(2,5-dioxo-1-pyrrolidinyl) ester N,N'-Disuccinimidyl Glutarate DSG [Di(N-succinimidyl) glutarate Bis(2,5-dioxopyrrolidin-1-yl) glutarate Disuccinimidyl Glutarate (>97%) ADC Linkers,linker,inhibit,Inhibitor,cleavable,DSG Crosslinker,Antibody-drug conjugates linkers,ADC 79642-50-5 C13H14N2O8 Homobifunctional Crosslinker