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BENZILIC ACID 1-ETHYLPIPERIDIN-3-YL ESTER METHOBROMIDE

CAS No.
125-51-9
Chemical Name:
BENZILIC ACID 1-ETHYLPIPERIDIN-3-YL ESTER METHOBROMIDE
Synonyms
qpb;piptal;jb-323;Piptalake;Pipenzolate;PIPENZOLATE BROMIDE;pipenzolatemethobromide;PIPENZOLATE BROMIDE(SH);pipenzolatemethylbromide;XEDCWWFPZMHXCM-UHFFFAOYSA-M
CBNumber:
CB0381093
Molecular Formula:
C22H28BrNO3
Molecular Weight:
434.37
MDL Number:
MFCD00079275
MOL File:
125-51-9.mol
MSDS File:
SDS
Last updated:2023-05-04 15:05:47

BENZILIC ACID 1-ETHYLPIPERIDIN-3-YL ESTER METHOBROMIDE Properties

Melting point 179-180°
form powder
color white
FDA UNII JPX41DUS2B
ATC code A03AB14

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
RTECS  TN5425000
Toxicity LD50 oral in rat: 916mg/kg

BENZILIC ACID 1-ETHYLPIPERIDIN-3-YL ESTER METHOBROMIDE price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC P479853 Piptalake 125-51-9 100mg $450 2021-12-16 Buy
American Custom Chemicals Corporation API0003871 PIPENZOLATE BROMIDE 95.00% 125-51-9 10G $1275.81 2021-12-16 Buy
AK Scientific 2658AH Pipenzolatebromide 125-51-9 1g $2625 2021-12-16 Buy
American Custom Chemicals Corporation API0003871 PIPENZOLATE BROMIDE 95.00% 125-51-9 50G $2677.14 2021-12-16 Buy
Crysdot CD31004085 Pipenzolatebromide 98+% 125-51-9 100mg $49 2021-12-16 Buy
Product number Packaging Price Buy
P479853 100mg $450 Buy
API0003871 10G $1275.81 Buy
2658AH 1g $2625 Buy
API0003871 50G $2677.14 Buy
CD31004085 100mg $49 Buy

BENZILIC ACID 1-ETHYLPIPERIDIN-3-YL ESTER METHOBROMIDE Chemical Properties,Uses,Production

Originator

Piptal ,Merrell National ,US ,1955

Uses

antispasmodic

Uses

Piptalake is used in the treatment with copper-tolylterpyridine and platinum-tolylterpyridine that targets telomeres and telomerase for regulation of chromosome mis-segregation rates for cancer therapy.

Manufacturing Process

N-ethyl-3-chloropiperidine was prepared according to the method of Fuson and Zirkle described in Volume 70, J. Am. Chem. Soc., p 2760. 12.0 g (0.081 mol) of N-ethyl-3-chloropiperidine was mixed with 18.6 g (0.081 mol) of benzilic acid and 80 cc of anhydrous isopropyl alcohol as a solvent. The mixture was refluxed for 72 hours. The solution was then filtered and concentrated at 30 mm of mercury. The concentrate was dissolved in water, acidified with hydrochloric acid and extracted with ether to remove theThe aqueous layer was neutralized with sodium bicarbonate and the product was extracted with ether. The ethereal solution of the product was dried with potassium carbonate, the ether was removed by distillation and the residue was distilled at 0.12 to 0.18 mm of mercury, the BP being 194° to 198°C. A yield of 16.5 g (60% of theoretical) of N-ethyl-3-piperidyl-benzilate was obtained.
34 g (0.1 mol) of the basic ester is dissolved in 75 cc of isopropyl alcohol and treated with 9.5 g (0.1 mol) of methyl bromide. The mixture is allowed to stand at room temperature until precipitation is complete. The product is removed by filtration and washed with isopropyl alcohol, yield 33 g, MP 175° to 177°C. On recrystallization from isopropyl alcohol, the MP was raised to 179° to 180°C dec.

brand name

Piptal (Marion Merrell Dow).

Therapeutic Function

Spasmolytic

BENZILIC ACID 1-ETHYLPIPERIDIN-3-YL ESTER METHOBROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

BENZILIC ACID 1-ETHYLPIPERIDIN-3-YL ESTER METHOBROMIDE Suppliers

Global( 32)Suppliers
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PIPENZOLATE BROMIDE 1-ethyl-3-hydroxy-1-methyl-piperidiniumbromidebenzilate 1-ethyl-3-piperidylbenzilatemethylbromide benzilicacid,1-ethyl-3-piperidylestermethylbromide benzilicacid,esterwith1-ethyl-3-hydroxy-1-methylpiperidiniumbromide jb-323 n-ethyl-3-piperidylbenzilatemethobromide pipenzolatemethobromide pipenzolatemethylbromide piperidinium,1-ethyl-3-hydroxy-1-methyl-,bromide,benzilate piptal qpb BENZILIC ACID 1-ETHYLPIPERIDIN-3-YL ESTER METHOBROMIDE 3-benziloyloxy-1-ethyl-1-methylpiperidinium bromide pipenzolate bromide sigmaultra Pipenzolate PIPENZOLATEBROMIDE,ULTRAPURE PIPENZOLATE BROMIDE(SH) 1-Ethyl-3-(2-hydroxy-2,2-diphenylacetoxy)-1-Methylpiperidin-1-iuM broMide 1-Ethyl-3-(2-hydroxy-2,2-diphenylacetoxy)-1-methyl-1-piperidinium Bromide XEDCWWFPZMHXCM-UHFFFAOYSA-M Piptalake Pipenzolate BromideQ: What is Pipenzolate Bromide Q: What is the CAS Number of Pipenzolate Bromide Q: What is the storage condition of Pipenzolate Bromide Piperidinium, 1-ethyl-3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-1-methyl-, bromide (1:1) 125-51-9 C22H28BrNO3 C22H28NO3Br Building Blocks Heterocyclic Building Blocks Piperidines PIPTAL Inhibitors Building Blocks C16 to C36 Chemical Synthesis Heterocyclic Building Blocks Piperidines