ISOXAFLUTOLE
- CAS No.
- 141112-29-0
- Chemical Name:
- ISOXAFLUTOLE
- Synonyms
- MERLIN;BALANCE;Ift cpd;Hsdb 7275;Isoxautole;Exp 31130a;SOXAFLUTOLE;ISOXAFLUTOLE;Isoxaflutole 0;Isoxaflutole [iso]
- CBNumber:
- CB0382227
- Molecular Formula:
- C15H12F3NO4S
- Molecular Weight:
- 359.32
- MDL Number:
- MFCD03095707
- MOL File:
- 141112-29-0.mol
- MSDS File:
- SDS
| Melting point | 138-138.5° (Cain); mp 140° |
|---|---|
| Boiling point | 575.1±50.0 °C(Predicted) |
| Density | 1.59 |
| Flash point | >130 °C |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Chloroform, DCM, Ethyl Acetate, Methanol |
| pka | -4.29±0.50(Predicted) |
| form | Solid |
| color | White |
| BRN | 8344543 |
| LogP | 2.320 |
| CAS DataBase Reference | 141112-29-0 |
| EWG's Food Scores | 3 |
| FDA UNII | 0T9R0O0EYT |
| Proposition 65 List | Isoxaflutole |
| Pesticides Freedom of Information Act (FOIA) | Isoxaflutole |
| EPA Substance Registry System | Isoxaflutole (141112-29-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H361d-H410 |
| Precautionary statements | P202-P273-P280-P308+P313-P391-P405 |
| Hazard Codes | Xn,N |
| Risk Statements | 50/53-63 |
| Safety Statements | 36/37-60-61 |
| RIDADR | UN3077 9/PG 3 |
| WGK Germany | 3 |
| Toxicity | LD50 in rats, quails, mallard ducks (mg/kg): >5000, >2150, >2150 orally; in rabbits (mg/kg): >2000 dermally (Luscombe) |
ISOXAFLUTOLE price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 46437 | Isoxaflutole PESTANAL?, analytical standard | 141112-29-0 | 100mg | $147 | 2024-03-01 | Buy |
| TRC | I918140 | Isoxaflutole | 141112-29-0 | 10mg | $580 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 71008 | Isoxaflutole | 141112-29-0 | 2.5mg | $675 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | AGR0000257 | ISOXAFLUTOLE 95.00% | 141112-29-0 | 5MG | $496 | 2021-12-16 | Buy |
| Crysdot | CD11263309 | (5-Cyclopropylisoxazol-4-yl)(2-(methylsulfonyl)-4-(trifluoromethyl)phenyl)methanone 95+% | 141112-29-0 | 1g | $89 | 2021-12-16 | Buy |
ISOXAFLUTOLE Chemical Properties,Uses,Production
Description
Isoxaflutole is a 4-benzoyl isoxazole molecule and is used as a pre- and early post-emergence herbicide for the control of a wide range of important broadleaf and grass weeds in maize (Zea mays), both in Europe and in North America. It is also registered for use in sugarcane in Central and South America (2–4). It causes characteristic bleaching of newly developed tissues of susceptible species followed by growth cessation and necrosis. Marketed as Balance for corn (maize) in the United States, and Merlin for corn in Europe; and in sugarcane, it mixes well with metolachlor, acetochlor, dimethenamid, and atrazine to complete the weed spectrum and to reduce the application rates of the latter compounds (2). Isoxaflutole also controls triazineresistant weeds in the field (4).
Uses
Isoxaflutole is an pesticide used to selectively control both grass and broad-leaved weeds in maize and sugar cane. Isoxaflutole is known to work by inhibiting the enzyme 4-Hydroxyphenylpyruvate dioxygenase (HPPD) which results in the disruption of pigment biosynthesis.
Uses
Herbicide.
Definition
ChEBI: Isoxaflutole is a member of the class of isoxazoles that is 1,2-oxazole substituted by a 2-(methanesulfonyl)-4-(trifluoromethyl)benzoyl group and a cyclopropyl group at positions 4 and 5, respectively. It is a 4-hydroxyphenylpyruvate dioxygenase inhibitor which is used as a herbicide for weed control in maize and sugarcane. It has a role as an EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor, a proherbicide and an agrochemical. It is a member of cyclopropanes, a member of isoxazoles, an aromatic ketone, a member of (trifluoromethyl)benzenes and a sulfone.
Pharmacology
Isoxaflutole is readily taken up by roots and foliar
tissues and then rapidly degraded to a diketonitrile derivative
(2-cyclopropyl-3-(2-mesyl-4-trifluoromethylphenyl)-
3-oxo propanenitrile) , which is translocated
throughout the plant via xylem and phloem (2,3,6,8). It
is this metabolite that inhibits HPPD (7), thereby depleting
the plastoquinone pools in developing leaves. Plastoquinone
is a cofactor in the desaturation of phytoene, levels
of which increase in bleached leaves, concomitant with
decreases in colored carotenoids (6). Although bleaching
is the primary symptom associated with HPPD inhibition,
subsequent growth suppression and necrosis are also
believed to be a consequence (8).
Isoxaflutole also degrades to the diketonitrile derivative
in the soil (3,8). The half-life of isoxaflutole in soil
is dependent on soil type, pH, and moisture, ranging
from 12 hours to 3 days under laboratory conditions (8).
The physicochemical properties of isoxaflutole and of
diketonitrile play an important role in both soil and
herbicidal activity and selectivity (8).
ISOXAFLUTOLE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou FandaChem Co.,Ltd. | +8615858145714 | FandaChem@Gmail.com | China | 9220 | 55 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29815 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32038 | 58 |
| Longyan Tianhua Biological Technology Co., Ltd | 0086 18039857276 18039857276 | CHINA | 2783 | 58 | |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
| Henan Alfa Chemical Co., Ltd | +86-18339805032; +8618339805032 | alfa4@alfachem.cn | China | 13227 | 58 |
View Lastest Price from ISOXAFLUTOLE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-01 | Isoxaflutole
141112-29-0
|
US $42.00-68.00 / mg | 98.49% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-12-24 | ISOXAFLUTOLE
141112-29-0
|
US $1.00 / g | 1g | 99.99% | 200kg | Career Henan Chemical Co |
-
- Isoxaflutole
141112-29-0
- US $42.00-68.00 / mg
- 98.49%
- TargetMol Chemicals Inc.
-
- ISOXAFLUTOLE
141112-29-0
- US $1.00 / g
- 99.99%
- Career Henan Chemical Co