5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE
- CAS No.
- 493028-20-9
- Chemical Name:
- 5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE
- Synonyms
- CBFβ Inhibitor;CBFβ Inhibitor;TIMTEC-BB SBB011699;Runx1-CBFβ interaction inhibitor 1;2-Thiazolamine, 5-ethyl-4-(4-methoxyphenyl)-;CBFβ Inhibitor - CAS 493028-20-9 - Calbiochem;5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE;5-ethyl-4-(4-methoxyphenyl)-1,3-thiazol-2-amine
- CBNumber:
- CB0412427
- Molecular Formula:
- C12H14N2OS
- Molecular Weight:
- 234.32
- MDL Number:
- MFCD02232182
- MOL File:
- Mol file
SAFETY
Risk and Safety Statements
| Hazard Codes | Xi |
|---|---|
| HazardClass | IRRITANT |
5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16771 | CBFβ Inhibitor ≥98% | 493028-20-9 | 5mg | $72 | 2024-03-01 | Buy |
| Cayman Chemical | 16771 | CBFβ Inhibitor ≥98% | 493028-20-9 | 10mg | $135 | 2024-03-01 | Buy |
| Cayman Chemical | 16771 | CBFβ Inhibitor ≥98% | 493028-20-9 | 25mg | $301 | 2024-03-01 | Buy |
| ApexBio Technology | C3398 | CBFβInhibitor | 493028-20-9 | 25mg | $342 | 2021-12-16 | Buy |
| AK Scientific | 4241AE | 5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine | 493028-20-9 | 1g | $432 | 2021-12-16 | Buy |
5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Chemical Properties,Uses,Production
Description
Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias. CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 μM). It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity.
Uses
Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias. CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 μM). It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity.
5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| Changzhou Hopschain Chemical Co.,Ltd. | 0519-85528066 13775048983 | sales@hopschem.com | China | 31557 | 55 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23963 | 58 |
| Shanghai Haohong Scientific Co., Ltd. | 400-400-8210725 | malulu@leyan.com | China | 39953 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8739 | 58 |