Pantoprazole Sodium
- CAS No.
- 138786-67-1
- Chemical Name:
- Pantoprazole Sodium
- Synonyms
- PANTOZOL;Pantoloc;Protonix;Pantoprazol Sodium;Zurcal;Nolpaza;PANTECTA;EUPANTOL;Controloc;midazolesodium
- CBNumber:
- CB0415897
- Molecular Formula:
- C16H14F2N3NaO4S
- Molecular Weight:
- 405.35
- MDL Number:
- MFCD01658543
- MOL File:
- 138786-67-1.mol
| Melting point | 199-202°C |
|---|---|
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly) |
| form | Solid |
| color | White to Pale Beige |
| Stability | Hygroscopic |
| InChI | InChI=1S/C16H14F2N3O4S.Na/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16;/h3-7,15H,8H2,1-2H3;/q-1;+1 |
| InChIKey | YNWDKZIIWCEDEE-UHFFFAOYSA-N |
| SMILES | C12C=C(C=CC=1N(C(S(=O)CC1N=CC=C(OC)C=1OC)=N2)[Na])OC(F)F |
| CAS DataBase Reference | 138786-67-1(CAS DataBase Reference) |
| FDA UNII | S9363155XL |
| NCI Drug Dictionary | pantoprazole sodium |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301+P312+P330 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-37/38-41-48 |
| Safety Statements | 22-26-36/37/39-45 |
Pantoprazole Sodium price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0001001 | Pantoprazole for system suitability European Pharmacopoeia (EP) Reference Standard | 138786-67-1 | y0001001 | $220 | 2024-03-01 | Buy |
| Usbiological | P3040 | Pantoprazole, Sodium Salt | 138786-67-1 | 100mg | $403 | 2021-12-16 | Buy |
| TRC | P183000 | PantoprazoleSodiumSalt | 138786-67-1 | 1g | $970 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 12899 | Pantoprazolesodiumsalt | 138786-67-1 | 250mg | $590 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 12899 | Pantoprazolesodiumsalt | 138786-67-1 | 50mg | $190 | 2021-12-16 | Buy |
Pantoprazole Sodium Chemical Properties,Uses,Production
Chemical Properties
White to Off-White Solid
Originator
Controloc,Byk Gulden ,Germany
Uses
An antiulcerative. Gastric pump inhibitor.
Uses
Gastrointestinal
Definition
ChEBI: Pantoprazole sodium is an organic sodium salt. It has a role as an EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor and an anti-ulcer drug. It contains a pantoprazole(1-).
Manufacturing Process
2-Chloromethyl-4,5-dimethoxy-3-methylpyridinium chloride (about 1.5 g) are added to a solution of 5-difluoromethoxy-1H-benzimidazole-2-thiol in 10 ml of ethanol and 10 ml of 1 N sodium hydroxide solution. The yellow reaction mixture is stirred at 20°C for 1 hour, a further 10 ml of water are added,
whereupon a colorless solid precipitates out, the mixture is stirred for a further 5 hours and filtered and the residue is rinsed with 1 N sodium hydroxide solution and water and dried to constant weight. The 5difluoromethoxy-2-[(4,5-dimethoxy-2-pyridyl)methylthio]-1H-benzimidazole is obtained as an oil.
5-Difluoromethoxy-2-[(4,5-dimethoxy-2-pyridyl)methylthio]-1H-benzimidazole (about 1 g) are dissolved in 10 ml of dioxane and 2 ml of 1 N sodium hydroxide solution. An equimolar amount of a titrated aqueous sodium hypochlorite solution, to which 1 mole per liter of sodium hydroxide solution has been added, is first added dropwise, while cooling with ice. After one hour a further equivalent and after 3 hours half the equimolar amount of sodium hypochlorite are added, to achieve complete reaction. After a reaction time of 4 hours, 5 ml of 5% strength sodium thiosulfate solution and another 25 ml of dioxane are added and the upper dioxane phase is separated off, washed once with 5 ml of sodium thiosulfate solution and concentrated on a rotary evaporator. The oily residue is dissolved in 20 ml of water and 10 ml of ethyl acetate and the solution is brought to pH 7 with about 100 ml of a buffer solution of pH 6.8. The solid which has precipitated out is filtered off with suction over a suction filter, washed with water, extracted by stirring at 0C with acetone and dried. 5-Difluoromethoxy-2-[(4,5-dimethoxy-2pyridyl)methanesulfinyl]-1H-benzimidazole is prepared; yield about 85%.
brand name
Protonix (Wyeth).
Therapeutic Function
Antiulcer
General Description
Pantoprazole sodium, racemicsodium5-(difluoromethoxy)-2-[[3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sesquihydrate is a white tooff-white crystalline powder that is freely soluble in water,very slightly soluble in phosphate buffer at pH 7.4, and practicallyinsoluble in n-hexane. The benzimidazole of this drughas a weakly basic nitrogen (pyridine N, pKa 3.83) and an benzimidazoleproton (pKa 0.11), facilitating formulation as asodium salt. The stability of the compound in aqueous solutionis pH dependent; the rate of degradation increases with decreasingpH. At ambient temperature, the degradation half-lifeis approximately 2.8 hours at pH 5.0 and approximately 220hours at pH 7.8.
The absorption of pantoprazole is rapid (Cmax of2.5μg/mL, Tmax 2.5 hours) after single or multiple oral40-mg doses. Pantoprazole is well absorbed (77% bioavailability).Administration with food may delay its absorptionbut does not alter pantoprazole bioavailability. Pantoprazoleis distributed mainly in extracellular fluid. The serum proteinbinding of pantoprazole is about 98%, primarily to albumin.Pantoprazole is extensively metabolized in the liver throughthe CYP system, including O-demethylation (CYP2C19),with subsequent sulfation. Other metabolic pathways includesulfur oxidation by CYP3A4. There is no evidencethat any of the pantoprazole metabolites have significantpharmacological activity. Approximately 71% of a dose of pantoprazole is excreted in the urine, with 18% excretedin the feces through biliary excretion.
Pantoprazole Sodium Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd. | +86-029-86185165 +8618629664246 | guoyuan@eastchinapharm.com | China | 1615 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12840 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Sigma Audley | +86-15937194204 +86-18126314766 | nova@sh-teruiop.com | China | 467 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 | sarah@tnjone.com | China | 1143 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 | info@tnjchem.com | China | 2986 | 55 |
| Shanxi Naipu Import and Export Co.,Ltd | +86-13734021967 +8613734021967 | kaia@neputrading.com | China | 1001 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29884 | 58 |
View Lastest Price from Pantoprazole Sodium manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-22 | Pantoprazole Sodium
138786-67-1
|
US $1.00 / KG | 1KG | 99.0%~101.0%,EP9.0 | 1000kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2024-11-19 | Pantoprazole sodium
138786-67-1
|
US $50.00 / mg | 99.1% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-14 | Pantoprazole Sodium
138786-67-1
|
US $460.00 / Kg/Bag | 1KG | 99% | 1T | Baoji Guokang Bio-Technology Co., Ltd. |
-
- Pantoprazole Sodium
138786-67-1
- US $1.00 / KG
- 99.0%~101.0%,EP9.0
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Pantoprazole sodium
138786-67-1
- US $50.00 / mg
- 99.1%
- TargetMol Chemicals Inc.
-
- Pantoprazole Sodium
138786-67-1
- US $460.00 / Kg/Bag
- 99%
- Baoji Guokang Bio-Technology Co., Ltd.
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