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Pantoprazole Sodium

CAS No.
138786-67-1
Chemical Name:
Pantoprazole Sodium
Synonyms
PANTOZOL;Pantoloc;Protonix;Pantoprazol Sodium;Zurcal;Nolpaza;PANTECTA;EUPANTOL;Controloc;midazolesodium
CBNumber:
CB0415897
Molecular Formula:
C16H14F2N3NaO4S
Molecular Weight:
405.35
MDL Number:
MFCD01658543
MOL File:
138786-67-1.mol
Last updated:2025-01-27 09:38:02

Pantoprazole Sodium Properties

Melting point 199-202°C
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly)
form Solid
color White to Pale Beige
Stability Hygroscopic
InChI InChI=1S/C16H14F2N3O4S.Na/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16;/h3-7,15H,8H2,1-2H3;/q-1;+1
InChIKey YNWDKZIIWCEDEE-UHFFFAOYSA-N
SMILES C12C=C(C=CC=1N(C(S(=O)CC1N=CC=C(OC)C=1OC)=N2)[Na])OC(F)F
CAS DataBase Reference 138786-67-1(CAS DataBase Reference)
FDA UNII S9363155XL
NCI Drug Dictionary pantoprazole sodium
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xn
Risk Statements  20/21/22-37/38-41-48
Safety Statements  22-26-36/37/39-45

Pantoprazole Sodium price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0001001 Pantoprazole for system suitability European Pharmacopoeia (EP) Reference Standard 138786-67-1 y0001001 $220 2024-03-01 Buy
Usbiological P3040 Pantoprazole, Sodium Salt 138786-67-1 100mg $403 2021-12-16 Buy
TRC P183000 PantoprazoleSodiumSalt 138786-67-1 1g $970 2021-12-16 Buy
Medical Isotopes, Inc. 12899 Pantoprazolesodiumsalt 138786-67-1 250mg $590 2021-12-16 Buy
Medical Isotopes, Inc. 12899 Pantoprazolesodiumsalt 138786-67-1 50mg $190 2021-12-16 Buy
Product number Packaging Price Buy
Y0001001 y0001001 $220 Buy
P3040 100mg $403 Buy
P183000 1g $970 Buy
12899 250mg $590 Buy
12899 50mg $190 Buy

Pantoprazole Sodium Chemical Properties,Uses,Production

Chemical Properties

White to Off-White Solid

Originator

Controloc,Byk Gulden ,Germany

Uses

An antiulcerative. Gastric pump inhibitor.

Uses

Gastrointestinal

Definition

ChEBI: Pantoprazole sodium is an organic sodium salt. It has a role as an EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor and an anti-ulcer drug. It contains a pantoprazole(1-).

Manufacturing Process

2-Chloromethyl-4,5-dimethoxy-3-methylpyridinium chloride (about 1.5 g) are added to a solution of 5-difluoromethoxy-1H-benzimidazole-2-thiol in 10 ml of ethanol and 10 ml of 1 N sodium hydroxide solution. The yellow reaction mixture is stirred at 20°C for 1 hour, a further 10 ml of water are added, whereupon a colorless solid precipitates out, the mixture is stirred for a further 5 hours and filtered and the residue is rinsed with 1 N sodium hydroxide solution and water and dried to constant weight. The 5difluoromethoxy-2-[(4,5-dimethoxy-2-pyridyl)methylthio]-1H-benzimidazole is obtained as an oil.
5-Difluoromethoxy-2-[(4,5-dimethoxy-2-pyridyl)methylthio]-1H-benzimidazole (about 1 g) are dissolved in 10 ml of dioxane and 2 ml of 1 N sodium hydroxide solution. An equimolar amount of a titrated aqueous sodium hypochlorite solution, to which 1 mole per liter of sodium hydroxide solution has been added, is first added dropwise, while cooling with ice. After one hour a further equivalent and after 3 hours half the equimolar amount of sodium hypochlorite are added, to achieve complete reaction. After a reaction time of 4 hours, 5 ml of 5% strength sodium thiosulfate solution and another 25 ml of dioxane are added and the upper dioxane phase is separated off, washed once with 5 ml of sodium thiosulfate solution and concentrated on a rotary evaporator. The oily residue is dissolved in 20 ml of water and 10 ml of ethyl acetate and the solution is brought to pH 7 with about 100 ml of a buffer solution of pH 6.8. The solid which has precipitated out is filtered off with suction over a suction filter, washed with water, extracted by stirring at 0C with acetone and dried. 5-Difluoromethoxy-2-[(4,5-dimethoxy-2pyridyl)methanesulfinyl]-1H-benzimidazole is prepared; yield about 85%.

brand name

Protonix (Wyeth).

Therapeutic Function

Antiulcer

General Description

Pantoprazole sodium, racemicsodium5-(difluoromethoxy)-2-[[3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sesquihydrate is a white tooff-white crystalline powder that is freely soluble in water,very slightly soluble in phosphate buffer at pH 7.4, and practicallyinsoluble in n-hexane. The benzimidazole of this drughas a weakly basic nitrogen (pyridine N, pKa 3.83) and an benzimidazoleproton (pKa 0.11), facilitating formulation as asodium salt. The stability of the compound in aqueous solutionis pH dependent; the rate of degradation increases with decreasingpH. At ambient temperature, the degradation half-lifeis approximately 2.8 hours at pH 5.0 and approximately 220hours at pH 7.8.
The absorption of pantoprazole is rapid (Cmax of2.5μg/mL, Tmax 2.5 hours) after single or multiple oral40-mg doses. Pantoprazole is well absorbed (77% bioavailability).Administration with food may delay its absorptionbut does not alter pantoprazole bioavailability. Pantoprazoleis distributed mainly in extracellular fluid. The serum proteinbinding of pantoprazole is about 98%, primarily to albumin.Pantoprazole is extensively metabolized in the liver throughthe CYP system, including O-demethylation (CYP2C19),with subsequent sulfation. Other metabolic pathways includesulfur oxidation by CYP3A4. There is no evidencethat any of the pantoprazole metabolites have significantpharmacological activity. Approximately 71% of a dose of pantoprazole is excreted in the urine, with 18% excretedin the feces through biliary excretion.

Biological Activity

Gastric proton pump inhibitor. It is used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.

102625-70-7
138786-67-1
Synthesis of Pantoprazole Sodium from Pantoprazole

Pantoprazole Sodium Preparation Products And Raw materials

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View Lastest Price from Pantoprazole Sodium manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
 Pantoprazole Sodium  pictures 2025-03-04 Pantoprazole Sodium
138786-67-1
US $150.00 / kg 1kg 99% 500kg Hebei Zhuanglai Chemical Trading Co Ltd
Pantoprazole Sodium pictures 2025-02-28 Pantoprazole Sodium
138786-67-1
US $100.00 / KG 1KG 99% 5000kg/week Hebei Mujin Biotechnology Co.,Ltd
Pantoprazole Sodium pictures 2025-02-12 Pantoprazole Sodium
138786-67-1
US $1.00 / KG 1KG 99.0%~101.0%,EP9.0 1000kg/month WUHAN FORTUNA CHEMICAL CO., LTD
5-(DIFLUOROMETHOXY)-2-[[(3,4-DIMETHOXY-2-PYRIDINYL)METHYL]SULFINYL]-1H-BENZIMIDAZOLE 5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl) sulfinyl)-1h-benzimidazole sodium 1h-benzimidazole,5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl)sul 5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl)sulfinyl)-1h-benzi midazolesodium EUPANTOL PANTOPRAZOLE SODIUM PANTOPRAZOLE, SODIUM SALT PANTECTA 1H-benziMidazole, 5-(difluoroMethoxy)-2-[[(3,4-diMethoxy-2-pyridinyl)Methyl]sulfinyl]-, sodiuM salt (1:1) Protonix sodiuM SKF96022 sodiuM sodiuM (S)-6-(difluoroMethoxy)-2-((3,4-diMethoxypyridin-2-yl)Methylsulfinyl)benzo[d]iMidazol-1-ide 5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt sesquihydrate Pantozol sesquihydrate Protonix sesquihydrate 5-(difluoroMethoxy)-2-(((3,4-diMethoxypyridin-2-yl)Methyl)sulfinyl)-1H-benzo[d]iMidazole, sodiuM salt 6-(difluoromethoxy)-2-[(3,4-dimethoxy-2-pyridyl)methylsulfinyl]-1H-benzimidazole PANTOPRAZOLE SODIUM POWDER 5-Difluoromethoxy-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt monohydrate Pantoprazole (as Sodium Salt) Eupantol, Pantecta, Pantozol, 5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole PANTOPRAZOLE SODIUM MONOHYDRATE Pantoprazole sodium(factory standard) 5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridynyl)methyl]-1H-benzimidazol-1-ium sodium salt Controloc Sodium pantoprazole Pantaprazole SodiuM sesqhydrate IP 5-(DifluoroMethoxy)-2-[[(3,4-diMethoxy-2-pyridinyl)Methyl]sulfinyl]- 1H-benziMidazole SodiuM Salt 6-(DifluoroMethoxy)-2-[[(3,4-diMethoxy-2-pyridinyl)Methyl]sulfinyl]-1H-benziMidazole SodiuM Salt Nolpaza Zurcal Pantoprazole Sodium (250 mg) Pantoprazole Sodium Gb 4-dimethoxy-2-pyridinyl)methyl) sulfinyl)-1H-benzimidazole sodium 5-(difluoromethoxy)-2-[(3,4-dimethoxy-2-pyridinyl)methylsulfinyl]benzimidazol-1-ide BY-1023 sodium BY1023 (sodium) 1H-Benzimidazole, 6-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-, sodium salt (1:1) Sodium 5-(difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (+/-)-PANTOPRAZOLE, SODIUM SALT: SESQUI- HYDRATE (PYRIDYL-4-METHOXY-13C, 98%) Pantoprazole sodium sisquehydrate Pantoprazole Sodium USP/EP/BP Hrk 99% Pure Pharmaceutical Raw Materials Pantoprazole Sodium CAS?138786-67-1 Pantoprazole Sodium (SKF96022) Pantoprazole SodiumQ: What is Pantoprazole Sodium Q: What is the CAS Number of Pantoprazole Sodium Q: What is the storage condition of Pantoprazole Sodium Q: What are the applications of Pantoprazole Sodium Pantoprazole Sodium BP/USP PANTOZOL Pantoloc Protonix Pantoprazol Sodium 6-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-Benzimidazole sodium salt (1:1) 6-(Difluoromethoxy)-2-(3,4-dimethoxy-pyridin-2-yl)methylsulfinyl-1H-benzodimidazole sodium salt Pantoprazole Na (IP/BP/EP/USP) PENTOPRAZOLE SODIUM Pantoprazole sodium (USP) pantoprazole sodium ip/usp Atazanavir Impurity 46