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3-Hydroxyazetidine hydrochloride

3-Hydroxyazetidine hydrochloride structure

CAS No.: 18621-18-6

Chemical Name:: 3-Hydroxyazetidine hydrochloride

Synonyms: AZETIDIN-3-OL HYDROCHLORIDE;3-AZETIDINOL HYDROCHLORIDE;3-HYDROXYAZETIDINE HCL;Azetidin-3-ol hydrochloride, 3-Hydroxyazetane hydrochloride;AZETAN-2-ONE;BUTTPARK 75\04-67;Azetidine-3-ol.Hcl;Baricitinib-009-HCl;3-hydroxyazatidine HCl;3-Hydroxyl-azetidine HCl

CBNumber:: CB0455455

Molecular Formula:: C3H8ClNO

Molecular Weight:: 109.55

MDL Number:: MFCD02683887

MOL File:: 18621-18-6.mol

MSDS File:: SDS

Last updated:2024-10-24 21:11:45

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3-Hydroxyazetidine hydrochloride Properties

Melting point	85-90 °C
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form	Solid
color	White to Off-White
Water Solubility	Soluble in water, DMSO, methanol.
Sensitive	Hygroscopic
Stability	Hygroscopic
InChI	InChI=1S/C3H7NO.ClH/c5-3-1-4-2-3;/h3-5H,1-2H2;1H
InChIKey	UQUPQEUNHVVNKW-UHFFFAOYSA-N
SMILES	C1(O)CNC1.Cl
CAS DataBase Reference	18621-18-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302-H315-H318-H335

Precautionary statements

P280-P301+P312+P330-P302+P352-P305+P351+P338+P310

Hazard Codes

C,Xi,Xn

Risk Statements

36/37/38-41-37/38-22

Safety Statements

26-36/37/39

RIDADR

UN1759

WGK Germany

Hazard Note

Harmful/Corrosive

HazardClass

IRRITANT

HS Code

29339900

NFPA 704

	1
2		0

3-Hydroxyazetidine hydrochloride price More Price(49)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	680079	3-Hydroxyazetidine hydrochloride 97%	18621-18-6	1g	$53.9	2024-03-01	Buy
Sigma-Aldrich	680079	3-Hydroxyazetidine hydrochloride 97%	18621-18-6	5g	$117.6	2024-03-01	Buy
TCI Chemical	H1264	3-Hydroxyazetidine Hydrochloride >98.0%(N)	18621-18-6	1g	$46	2024-03-01	Buy
TCI Chemical	H1264	3-Hydroxyazetidine Hydrochloride >98.0%(N)	18621-18-6	5g	$137	2024-03-01	Buy
Alfa Aesar	H25842	3-Hydroxyazetidine hydrochloride, 97%	18621-18-6	1g	$84.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
680079	1g	$53.9	Buy
680079	5g	$117.6	Buy
H1264	1g	$46	Buy
H1264	5g	$137	Buy
H25842	1g	$84.65	Buy

3-Hydroxyazetidine hydrochloride Chemical Properties,Uses,Production

Description

3-hydroxyazaecyclobutane hydrochloride is an azaecyclobutane compound that is an important intermediate in the synthesis of Brectinib, which is obtained through a multi-step reaction. Brectinib was approved by the European Union. The monotherapy or in combination with methotrexate for the treatment of adult patients with moderate to severe active rheumatoid arthritis with inadequate or intolerant relief from one or more antirheumatic drugs. It is also the first JAK inhibitor approved in the European Union for the treatment of rheumatoid arthritis.

Chemical Properties

white crystal

Uses

3-Hydroxyazetidine hydrochloride is an building block used in a recent synthesis of a fluoroquinolone antibiotic and a useful intermediate in the synthesis of polypeptides.

Synthesis

A solution of l-(diphenylmethyl)-3-hydroxy azetidine hydrochloride (11.8 g) in absolute ethanol (700 mL) was hydrogenated at room temperature over Pd(OH)2/C in a Parr shaker (4 atm). After 12 hr the catalyst was filtered off and the filtrate evaporated to dryness to give3-hydroxyazetidine hydrochloride (4.20 g, 94%).

3-Hydroxyazetidine hydrochloride synthesis

Synthesis of 3-Hydroxyazetidine hydrochloride from 1-(Diphenylmethyl)-3-Hydroxyazetidine Hydrochloride

3-Hydroxyazetidine hydrochloride Preparation Products And Raw materials

Raw materials

Ethanol Palladium Ethyl acetate Benzhydrylamine Hydrochloric acid

Methanol Epichlorohydrin Isopropyl alcohol Sodium carbonate 1-Azetidinecarboxylic acid, 2-hydroxy-, 1,1-dimethylethyl ester

1-benzylazetidin-3-ol hydrochloride 3-Azetidinol, 1-acetyl-, acetate (ester) (9CI) 1-benzhydrylazetidin-3-Ol 1-tert-Butylazetidin-3-ol 1-Benzylazetidin-3-ol

1-Azabicyclo[1.1.0]butane 1-(Diphenylmethyl)-3-Hydroxyazetidine Hydrochloride

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Preparation Products

1-N-Boc-3-hydroxyazetidine 1-Boc-3-(Amino)azetidine ABT-492

3-Hydroxyazetidine hydrochloride Suppliers

Global( 525)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Didu New Materials Co. Ltd	+86-89586680 +86-13289823923	1026@dideu.com	China	8670	58
Lianhe Aigen Pharmatech Co.,Ltd.	+undefined+undefined18918657159	sales-Aigen@lianhetech.com	China	314	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3002	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5857	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5892	58
Hebei Weibang Biotechnology Co., Ltd	+8617732866630	bess@weibangbio.com	China	18153	58
Shaanxi Haibo Biotechnology Co., Ltd	+undefined18602966907	qinhe02@xaltbio.com	China	997	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20287	58
Hebei Shengyang Water Conservancy Engineering Co., Ltd.	+8615373025980	clara@hbshengyang.com	China	874	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60

Supplier	Advantage
Shaanxi Didu New Materials Co. Ltd	58
Lianhe Aigen Pharmatech Co.,Ltd.	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hebei Weibang Biotechnology Co., Ltd	58
Shaanxi Haibo Biotechnology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Hebei Shengyang Water Conservancy Engineering Co., Ltd.	58
Capot Chemical Co.,Ltd.	60

View Lastest Price from 3-Hydroxyazetidine hydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-27	3-Hydroxyazetidine hydrochloride 18621-18-6	US $200.00-95.00 / kg	1kg	99%	20ton	Hebei Zhuanglai Chemical Trading Co.,Ltd
2024-11-27	3-Hydroxyazetidine hydrochloride 18621-18-6	US $0.00 / KG	1KG	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
2024-10-25	3-Hydroxyazetidine hydrochloride 18621-18-6	US $0.00 / kg	1kg	0.99	20tons	Hebei Yanxi Chemical Co., Ltd.

3-Hydroxyazetidine hydrochloride
18621-18-6
US $200.00-95.00 / kg
99%
Hebei Zhuanglai Chemical Trading Co.,Ltd

3-Hydroxyazetidine hydrochloride
18621-18-6
US $0.00 / KG
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

3-Hydroxyazetidine hydrochloride
18621-18-6
US $0.00 / kg
0.99
Hebei Yanxi Chemical Co., Ltd.

3-Hydroxyazetidine hydrochloride Spectrum

3-Hydroxyazetidine hydrochloride(18621-18-6)¹HNMR 3-Hydroxyazetidine hydrochloride(18621-18-6)FT-IR

18621-18-6(3-Hydroxyazetidine hydrochloride)Related Search:

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Mosapride citrate 1-(DIPHENYLMETHYL)-3-HYDROXYAZETIDINE HYDROCHLORIDE 3-AZETIDINOL 3-Methoxyazetidine hydrochloride 3-PROPOXY-AZETIDINE HYDROCHLORIDE

1-(Diphenylmethyl)-3-methyl-3-azetidinol hydrochloride 3-ETHOXY-AZETIDINE HYDROCHLORIDE 3-ISOPROPOXY-AZETIDINE HYDROCHLORIDE

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3-HYDROXYAZETIDINE HYDROCHLORIDE BUTTPARK 75\04-67 AZETIDIN-3-OL, HYDROCHLORIDE SALT AZETAN-2-ONE 3-hydroxyazatidine HCl 3-Hydroxyazetidine hydroc... 3-hydroxy-1-azetidine hydrochloride 3-Hydroxyazetidine Hydrochloride, 95+% 3 - hydroxy nitrogen heterocyclic butadiene hydrochloride 3-Azetidinol, hydrochloride (1:1) -Hydroxyazetidine hydrochloride 3-Hydroxyazetidine Hcl Salt 3-hydroxyazacyclobutane hydrochloride 3-HydroxyazetidineHydrochloride> 3-Hydroxyazetidine HydrochL Baricitinib-009-HCl Azetidine-3-ol.Hcl 3-Hydroxyl-azetidine HCl 3-AZETIDINOL HYDROCHLORIDE 3-HYDROXYAZETIDINE HCL AZETIDIN-3-OL HYDROCHLORIDE Azetidin-3-ol hydrochloride, 3-Hydroxyazetane hydrochloride Baricitinib Impurity 11 HCl Baricitinib Impurity 2 HCl 18621-18-6 8621-18-6 C3H7ClNO C3H8NOCl C3H7NOHCl C3H7NOClH Azetidines Amino Acids & Derivatives Heterocyclic Building Blocks N-Containing Others B-Amino Amino Acids 13C, 2H, 15N pharmacetical Azetidine Alcohols and Derivatives Heterocycles