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1-N-Boc-3-hydroxyazetidine

1-N-Boc-3-hydroxyazetidine structure

CAS No.: 141699-55-0

Chemical Name:: 1-N-Boc-3-hydroxyazetidine

Synonyms: TERT-BUTYL 3-HYDROXYAZETIDINE-1-CARBOXYLATE;N-BOC-3-HYDROXYAZETIDINE;Baricitinib-012;JACS-141699-55-0;BUTTPARK 75\04-65;N-Boc-3-Azetidinol;1-Boc-azetidin-3-ol;N-Boc-Azetidin-3-ol;carbamate (ARQ092 RSM2);1-BOC-3-(HYDROXY)AZETIDINE

CBNumber:: CB1428146

Molecular Formula:: C8H15NO3

Molecular Weight:: 173.21

MDL Number:: MFCD04115305

MOL File:: 141699-55-0.mol

MSDS File:: SDS

Last updated:2025-04-18 09:51:42

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1-N-Boc-3-hydroxyazetidine Properties

Melting point	36-43 °C
Boiling point	253.7±33.0 °C(Predicted)
Density	1.184±0.06 g/cm3(Predicted)
Flash point	>110℃
storage temp.	2-8°C
solubility	soluble in Methanol
form	Solid
pka	14.16±0.20(Predicted)
color	White to light yellow
InChIKey	XRRXRQJQQKMFBC-UHFFFAOYSA-N
CAS DataBase Reference	141699-55-0(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302-H315-H318-H335

Precautionary statements

P280-P301+P312+P330-P302+P352-P305+P351+P338+P310

Hazard Codes

Xi,Xn

Risk Statements

36/37/38-41-22

Safety Statements

26-36/37/39

WGK Germany

TSCA

HazardClass

IRRITANT

HS Code

29339900

NFPA 704

	1
2		0

1-N-Boc-3-hydroxyazetidine price More Price(52)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	694347	1-Boc-3-hydroxyazetidine 97%	141699-55-0	5g	$108	2024-03-01	Buy
Sigma-Aldrich	694347	1-Boc-3-hydroxyazetidine 97%	141699-55-0	1g	$26.2	2023-06-20	Buy
TCI Chemical	B2922	1-(tert-Butoxycarbonyl)-3-hydroxyazetidine >96.0%(GC)	141699-55-0	1g	$36	2024-03-01	Buy
TCI Chemical	B2922	1-(tert-Butoxycarbonyl)-3-hydroxyazetidine >96.0%(GC)	141699-55-0	5g	$69	2024-03-01	Buy
Alfa Aesar	H28902	1-Boc-3-hydroxyazetidine, 97%	141699-55-0	1g	$47.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
694347	5g	$108	Buy
694347	1g	$26.2	Buy
B2922	1g	$36	Buy
B2922	5g	$69	Buy
H28902	1g	$47.65	Buy

1-N-Boc-3-hydroxyazetidine Chemical Properties,Uses,Production

Chemical Properties

white powder

Uses

1-N-Boc-3-hydroxyazetidine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-N-Boc-3-hydroxyazetidine is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs

IC 50

Non-cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. DOI:10.1038/nrd.2016.268
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277

1-N-Boc-3-hydroxyazetidine synthesis

Synthesis of 1-N-Boc-3-hydroxyazetidine from Di-tert-butyl dicarbonate and 1-(Diphenylmethyl)-3-Hydroxyazetidine Hydrochloride

1-N-Boc-3-hydroxyazetidine Preparation Products And Raw materials

Raw materials

3-Hydroxyazetidine hydrochloride Acetonitrile Ammonium formate Toluene Di-tert-butyl dicarbonate

Triethylamine Benzophenone Palladium Ethyl acetate Hydrochloric acid

Hydrogen Dichloromethane Methanol Epichlorohydrin PETROLEUM ETHER

Citric acid 1-(Diphenylmethyl)-3-Hydroxyazetidine Hydrochloride 1-(TERT-BUTOXYCARBONYL)AZETIDINE

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Preparation Products

1-N-Boc-3-hydroxyazetidine Suppliers

Global( 443)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BTC Nantong Pharmaceuticals Technology Co.,Ltd	+8618068193575	sales4@btcpharm.com	China	251	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20228	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29730	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	19886	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29856	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	20208	58
Chengdu Pukang Biotechnology Co., Ltd	028-82550498	export@pu-kang.com	CHINA	210	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88299272	info@edengenechem.com	China	2176	58

Supplier	Advantage
BTC Nantong Pharmaceuticals Technology Co.,Ltd	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Jinan Carbotang Biotech Co.,Ltd.	58
Accela ChemBio Inc.	58
Chengdu Pukang Biotechnology Co., Ltd	58
Changzhou Ditong Chemical Co.,Ltd	58

View Lastest Price from 1-N-Boc-3-hydroxyazetidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-05-16	1-Boc-3-Hydroxyazetidine 141699-55-0	US $0.00 / Kg/Drum	1Kg/Drum	99%	5000KG	Hebei Mujin Biotechnology Co.,Ltd
2025-04-04	1-N-Boc-3-hydroxyazetidine 141699-55-0	US $0.00-0.00 / KG	1KG	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2024-02-26	1-N-Boc-3-hydroxyazetidine 141699-55-0	US $0.00-0.00 / kg	1kg	98%	Kgs	BTC Nantong Pharmaceuticals Technology Co.,Ltd

1-Boc-3-Hydroxyazetidine
141699-55-0
US $0.00 / Kg/Drum
99%
Hebei Mujin Biotechnology Co.,Ltd

1-N-Boc-3-hydroxyazetidine
141699-55-0
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

1-N-Boc-3-hydroxyazetidine
141699-55-0
US $0.00-0.00 / kg
98%
BTC Nantong Pharmaceuticals Technology Co.,Ltd

1-N-Boc-3-hydroxyazetidine Spectrum

1-N-Boc-3-hydroxyazetidine(141699-55-0)¹HNMR

141699-55-0(1-N-Boc-3-hydroxyazetidine)Related Search:

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BUTTPARK 75\04-65 3-HYDROXYAZETIDINE, N-BOC PROTECTED 3-HYDROXY-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-N-BOC-3-HYDROXYAZETIDINE 1-BOC-3-(HYDROXY)AZETIDINE 1-TERT-BUTOXYCARBONYL-3-AZETIDINOL 1-TERT-BUTOXYCARBONYL-3-HYDROXYAZETIDINE 3-Hydroxyazetidine, N-BOC protected 97% 1-tert-Butoxycarbonyl-3-azetidinol tert-butyl 3-hydroxyazetidine-1-carboxylate 1-BOC-3-(HYDROXY)AZETIDINE 1-(tert-Butoxycarbonyl)-3-azetidinol 1-(TERT-BUTOXYCARBONYL)-3-HYDROXYAZETIDINE,98.0%(GC) 1-Boc-azetidin-3-ol 1-Azetidinecarboxylic acid, 3-hydroxy-, 1,1-dimethylethyl ester tert-butyl 3-hydro×yazetidine-1-carbo×ylate 1-Boc-3-hydroxyazetidine tert-Butyl 3-Hydroxyazetidine-1-carboxylate 3-Hydroxyazetidine-1-carboxylic Acid tert-Butyl Ester tert-Butyl 3-hydroxyazetidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-3-hydroxyazetidine 1-Boc-3-(Hydroxy)azetidine ,97% carbamate (ARQ092 RSM2) 3-hydroxy-1-azetidinecarboxylic acid tert-butyl ester 1-Boc-3-hydroxyazetidine 97% N-Boc-Azetidin-3-ol 1-azetidinecarboxylic acid, 3-hydroxy-, 1,1-dimethylethyl JACS-141699-55-0 N-Boc-3-Azetidinol 1-(tert-Butoxycarbonyl)-3-hydroxyazetidine > Baricitinib-012 1-N-Boc-3-hydroxyazetidine ISO 9001：2015 REACH 1-N-Boc-3-hydroxyl-azetidine TERT-BUTYL 3-HYDROXYAZETIDINE-1-CARBOXYLATE N-BOC-3-HYDROXYAZETIDINE tert-butyl-3-hydroxyazetidine-4-carboxylate 1-Boc-3-hydroxyazetidine, 95% 141699-55-0 141699-88-0 41699-55-0 Ring Systems B-Amino Azetidines Simple 4-Membered Ring Compounds CMLLYL