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IITZ-01

IITZ-01 structure

CAS No.: 1807988-47-1

Chemical Name:: IITZ-01

Synonyms: IITZ-01;CS-2857;Autophagy inhibitor IITZ-01;AUTOPHAGY INHIBITOR;IITZ 01;IITZ01;AUTOPHAGY INHIBITOR IITZ-01;IITZ 01;IITZ01;Phosphoinositide 3-kinase,IITZ 01,IITZ01,Apoptosis,IITZ-01,Autophagy,inhibit,Inhibitor,PI3K;N2-(4-(1H-Benzo[d]imidazol-2-yl)phenyl)-N4-(4-fluorophenyl)-6-morpholino-1,3,5-triazine-2,4-diamine;N-[4-(1H-Benzimidazol-2-yl)phenyl]-N'-(4-fluorophenyl)-6-(4-morpholinyl)-1,3,5-triazine-2,4-diamine;1,3,5-Triazine-2,4-diamine, N2-[4-(1H-benzimidazol-2-yl)phenyl]-N4-(4-fluorophenyl)-6-(4-morpholinyl)-

CBNumber:: CB04668033

Molecular Formula:: C26H23FN8O

Molecular Weight:: 482.51

MDL Number:: MFCD31746904

MOL File:: 1807988-47-1.mol

Last updated:2024-10-30 20:13:01

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IITZ-01 Properties

Boiling point	747.0±70.0 °C(Predicted)
Density	1.420±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	DMSO:100.0(Max Conc. mg/mL);207.24(Max Conc. mM)
pka	11.55±0.10(Predicted)
form	Solid
color	White to off-white

IITZ-01 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0067546	IITZ-01 99.80%	1807988-47-1	5mg	$120	2021-12-16	Buy
AK Scientific	8048EL	4-N-[4-(1H-Benzimidazol-2-yl)phenyl]-2-N-(4-fluorophenyl)-6-morpholin-4-yl-1,3,5-triazine-2,4-diamine	1807988-47-1	5mg	$162	2021-12-16	Buy
ChemScene	CS-0067546	IITZ-01 99.80%	1807988-47-1	10mg	$210	2021-12-16	Buy
ChemScene	CS-0067546	IITZ-01 99.80%	1807988-47-1	25mg	$420	2021-12-16	Buy
ChemScene	CS-0067546	IITZ-01 99.80%	1807988-47-1	50mg	$680	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-0067546	5mg	$120	Buy
8048EL	5mg	$162	Buy
CS-0067546	10mg	$210	Buy
CS-0067546	25mg	$420	Buy
CS-0067546	50mg	$680	Buy

IITZ-01 Chemical Properties,Uses,Production

Biological Activity

IITZ-01 is a potent lysosomal autophagy inhibitor with antitumor activity, with IC50 value of 2.62 μM for PI3Kγ.

in vivo

IITZ-01 (45 mg/kg, ip every alternate day for 4 weeks) inhibits average breast tumor growth when compared with control from third day of treatment in triple-negative breast tumor models in mice.

Animal Model:	MDA-MB-231 (TNBC)/green fluorescent protein (GFP) orthotropic breast cancer xenografts were developed in CrTac:NCr- Foxn ^nu BALB/c female nude mice.
Dosage:	45 mg/kg.
Administration:	Intraperitoneal every alternate day for 4 weeks.
Result:	Inhibited average breast tumor growth when compared with control from third day of treatment.

target

PI3Kγ

2.62 μM (IC ₅₀ )

Autophagy

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IITZ-01 Preparation Products And Raw materials

Raw materials

Preparation Products

IITZ-01 Suppliers

Global( 59)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32820	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32038	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Chemia Biotechnology（Shanghai） Co., Ltd	+8613816753574	info@chemia-pharm.com	CHINA	311	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38463	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	5221	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Chemia Biotechnology（Shanghai） Co., Ltd	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
TargetMol Chemicals Inc.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Aladdin Scientific	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	58

View Lastest Price from IITZ-01 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-10-30	IITZ-01 1807988-47-1	US $33.00-118.00 / mg		99%	10g	TargetMol Chemicals Inc.

IITZ-01
1807988-47-1
US $33.00-118.00 / mg
99%
TargetMol Chemicals Inc.

IITZ-01 AUTOPHAGY INHIBITOR;IITZ 01;IITZ01 Autophagy inhibitor IITZ-01 AUTOPHAGY INHIBITOR IITZ-01;IITZ 01;IITZ01 CS-2857 1,3,5-Triazine-2,4-diamine, N2-[4-(1H-benzimidazol-2-yl)phenyl]-N4-(4-fluorophenyl)-6-(4-morpholinyl)- N-[4-(1H-Benzimidazol-2-yl)phenyl]-N'-(4-fluorophenyl)-6-(4-morpholinyl)-1,3,5-triazine-2,4-diamine Phosphoinositide 3-kinase,IITZ 01,IITZ01,Apoptosis,IITZ-01,Autophagy,inhibit,Inhibitor,PI3K N2-(4-(1H-Benzo[d]imidazol-2-yl)phenyl)-N4-(4-fluorophenyl)-6-morpholino-1,3,5-triazine-2,4-diamine 1807988-47-1 C26H23FN8O API