ChemicalBook >> CAS DataBase List >>HUWENTOXIN XVI

HUWENTOXIN XVI

CAS No.
1600543-88-1
Chemical Name:
HUWENTOXIN XVI
Synonyms
Cys8-Cys21;Cys15-Cys36);HUWENTOXIN XVI;H-Cys-Ile-Gly-Glu-Gly-Val-Pro-Cys-Asp-Glu-Asn-Asp-Pro-Arg-Cys-Cys-Ser-Gly-Leu-Val-Cys-Leu-Lys-Pro-Thr-Leu-His-Gly-Ile-Trp-Tyr-Lys-Ser-Tyr-Tyr-Cys-Tyr-Lys-Lys-OH(Disulfide bridge:Cys1-Cys16
CBNumber:
CB04733856
Molecular Formula:
C196H292N50O56S6
Molecular Weight:
0
MDL Number:
MOL File:
Mol file
Last updated:2023-05-21 10:59:17

HUWENTOXIN XVI Properties

storage temp. Store at -20°C
solubility Soluble to 1 mg/ml in H2O
form solid
color White
Water Solubility Soluble to 1 mg/ml in water

HUWENTOXIN XVI price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 255472 Huwentoxin XVI 1600543-88-1 100ug $573 2021-12-16 Buy
Product number Packaging Price Buy
255472 100ug $573 Buy

HUWENTOXIN XVI Chemical Properties,Uses,Production

Biological Activity

huwentoxin xvi(hwtx-xvi ) is composed of 39 amino acid residues including six cysteines. hwtx-xvi is a novel neurotoxin from the venom of chinese tarantula o. huwena. and specificially block n-type calcium channels. [1]n-type calcium channels are often highly expressed both in dorsal root ganglia cell bodies and in the synaptic terminals projecting to dorsal horn of the spinal cord n-type calcium channels play important roles in the control of neurotransmission release and transmission of pain signals to the central nervous system.[2]electrophysiological assay indicated that hwtx-xvi specifically inhibited n-type calcium channels in rat dorsal root ganglion cells. hwtx-xvi specifically inhibits gvia sensitive, n-type calcium channels in rat drg cells.[1]hwtx-xvi could almost completely block the twitch response of rat vas deferens to low-frequency electrical stimulation. hwtx-xvi ‘s analgesic effects, non-toxic and complete reversibility make it an interesting tool for developing novel drugs for the treatment of n-type calcium channel-related diseases.[1,2]

References

[1] deng m, luo x, xiao y etal. , huwentoxin-xvi, an analgesic, highly reversible mammalian n-type calcium channel antagonist from chinese tarantula ornithoctonus huwena. neuropharmacology. 2014 apr;79:657-67.
[2] liu z, dai j, dai l etal. , function and solution structure of huwentoxin-x, a specific blocker of n-type calcium channels, from the chinese bird spider ornithoctonus huwena. j biol chem. 2006 mar 31;281(13):8628-35.

HUWENTOXIN XVI Preparation Products And Raw materials

Raw materials

Preparation Products

HUWENTOXIN XVI Suppliers

Global( 28)Suppliers
Supplier Tel Email Country ProdList Advantage
Shenzhen Nexconn Pharmatechs Ltd
+86-755-89396905 +86-15013857715 admin@nexconn.com China 10259 58
BOC Sciences
16314854226; +16314854226 inquiry@bocsci.com United States 19743 58
Zhejiang Hangyu API Co., Ltd
+8617531972939 anna@api-made.com China 2944 58
Creative Peptides info@creative-peptides.com United States 6084 56
Hangzhou Peptidego Biotech Co.,Ltd. 0571-87213919 eric@peptidego.com China 6525 58
BOC Sciences -- info@bocsci.com USA 0 65
Hangzhou Go Top Peptide Biotech 0571-88211921 13355716090 Sales@gotopbio.com China 2842 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8141 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 psaitong@jm-bio.com China 29778 58
Shaoxing Junyu Biotechnology Co., LTD 0571-88211921 15572296305 sales4@gotopbio.com China 5144 58
HUWENTOXIN XVI Cys15-Cys36) Cys8-Cys21 H-Cys-Ile-Gly-Glu-Gly-Val-Pro-Cys-Asp-Glu-Asn-Asp-Pro-Arg-Cys-Cys-Ser-Gly-Leu-Val-Cys-Leu-Lys-Pro-Thr-Leu-His-Gly-Ile-Trp-Tyr-Lys-Ser-Tyr-Tyr-Cys-Tyr-Lys-Lys-OH(Disulfide bridge:Cys1-Cys16 1600543-88-1 C196H292N50O56S6