HUWENTOXIN XVI
- CAS No.
- 1600543-88-1
- Chemical Name:
- HUWENTOXIN XVI
- Synonyms
- Cys8-Cys21;Cys15-Cys36);HUWENTOXIN XVI;H-Cys-Ile-Gly-Glu-Gly-Val-Pro-Cys-Asp-Glu-Asn-Asp-Pro-Arg-Cys-Cys-Ser-Gly-Leu-Val-Cys-Leu-Lys-Pro-Thr-Leu-His-Gly-Ile-Trp-Tyr-Lys-Ser-Tyr-Tyr-Cys-Tyr-Lys-Lys-OH(Disulfide bridge：Cys1-Cys16
- CBNumber:
- CB04733856
- Molecular Formula:
- C196H292N50O56S6
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
HUWENTOXIN XVI Chemical Properties,Uses,Production
Biological Activity
huwentoxin xvi(hwtx-xvi ) is composed of 39 amino acid residues including six cysteines. hwtx-xvi is a novel neurotoxin from the venom of chinese tarantula o. huwena. and specificially block n-type calcium channels. [1]n-type calcium channels are often highly expressed both in dorsal root ganglia cell bodies and in the synaptic terminals projecting to dorsal horn of the spinal cord n-type calcium channels play important roles in the control of neurotransmission release and transmission of pain signals to the central nervous system.[2]electrophysiological assay indicated that hwtx-xvi specifically inhibited n-type calcium channels in rat dorsal root ganglion cells. hwtx-xvi specifically inhibits gvia sensitive, n-type calcium channels in rat drg cells.[1]hwtx-xvi could almost completely block the twitch response of rat vas deferens to low-frequency electrical stimulation. hwtx-xvi ‘s analgesic effects, non-toxic and complete reversibility make it an interesting tool for developing novel drugs for the treatment of n-type calcium channel-related diseases.[1,2]
References
[1] deng m, luo x, xiao y etal. , huwentoxin-xvi, an analgesic, highly reversible mammalian n-type calcium channel antagonist from chinese tarantula ornithoctonus huwena. neuropharmacology. 2014 apr;79:657-67.
[2] liu z, dai j, dai l etal. , function and solution structure of huwentoxin-x, a specific blocker of n-type calcium channels, from the chinese bird spider ornithoctonus huwena. j biol chem. 2006 mar 31;281(13):8628-35.
HUWENTOXIN XVI Preparation Products And Raw materials
Raw materials
Preparation Products
HUWENTOXIN XVI Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10318 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Zhejiang Hangyu API Co., Ltd | +8617531972939 | anna@api-made.com | China | 2944 | 58 |
| Creative Peptides | info@creative-peptides.com | United States | 6084 | 56 | |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 | eric@peptidego.com | China | 6526 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Hangzhou Go Top Peptide Biotech | 0571-88211921 13355716090 | Sales@gotopbio.com | China | 2842 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29778 | 58 |
| Shaoxing Junyu Biotechnology Co., LTD | 0571-88211921 15572296305 | sales4@gotopbio.com | China | 5144 | 58 |