GPBAR-A
- CAS No.
- 877052-79-4
- Chemical Name:
- GPBAR-A
- Synonyms
- GPBAR-A;GPBAR-A >=98% (HPLC);4-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-6-(2-fluorophenyl)-4,5-dihydro-pyrido[3,2-f]-1,4-oxazepin-3(2H)-one;Pyrido[3,2-f]-1,4-oxazepin-3(2H)-one, 4-[[3,5-bis(trifluoromethyl)phenyl]methyl]-6-(2-fluorophenyl)-4,5-dihydro-
- CBNumber:
- CB04738417
- Molecular Formula:
- C23H15F7N2O2
- Molecular Weight:
- 484.37
- MDL Number:
- MOL File:
- 877052-79-4.mol
GPBAR-A price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Tocris | 4478 | GPBAR-A ≥98%(HPLC) | 877052-79-4 | 10 | $220 | 2021-12-16 | Buy |
Tocris | 4478 | GPBAR-A ≥98%(HPLC) | 877052-79-4 | 50 | $905 | 2021-12-16 | Buy |
TRC | G932048 | GPBAR-A | 877052-79-4 | 5mg | $440 | 2021-12-16 | Buy |
Usbiological | 255392 | GPBAR-A | 877052-79-4 | 10mg | $502 | 2021-12-16 | Buy |
ApexBio Technology | B5616 | GPBAR-A | 877052-79-4 | 10mg | $377 | 2021-12-16 | Buy |
GPBAR-A Chemical Properties,Uses,Production
Uses
GPBAR-A is a GPBA receptor (TGR5) agonist.
Biological Activity
gpbar-a is an agonist of bile acid receptor gpbar1 [1].the g protein-coupled bile acid receptor 1 (gpbar1, tgr5) is a plasma membrane-bound receptor for bile acids. tgr5 is involved in gallstone formation and is expressed in the epithelium of human gallbladders [2].gpbar-a is an agonist of bile acid receptor gpbar1. in glutag cells, gpbar-a stimulated glucagon-like peptide (glp-1) release. in primary colonic cultures, gpbar-a increased glp-1 release by 4.2-fold. in upper small intestinal cultures, gpbar-a increased glp-1 release by 2.6-fold. in glutag cells, gpbar-a increased camp concentration by 57%. also, gpbar-a increased calcium in 56/149 cells and caused the mean response by 1.3-fold. in the presence of glucose, gpbar-a increased calcium in 148/149 cells and caused the mean response by 2.6-fold. in the presence of diazoxide (the katp channel opener, 340 μm) and 70 mm kcl, gpbar-a also increased glp-1 secretion. in colonic and small intestinal cultures, gpbar-a increased the glp-1 secretion by 2.4-fold and 1.5-fold. the glp-1 secretion mediated by gpbar-a was independent on katp channel closure [1].
storage
Store at -20°C
References
[1]. parker he, wallis k, le roux cw, et al. molecular mechanisms underlying bile acid-stimulated glucagon-like peptide-1 secretion. br j pharmacol, 2012, 165(2): 414-423.
[2]. keitel v, cupisti k, ullmer c, et al. the membrane-bound bile acid receptor tgr5 is localized in the epithelium of human gallbladders. hepatology, 2009, 50(3): 861-870.
GPBAR-A Preparation Products And Raw materials
Raw materials
Preparation Products
GPBAR-A Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4551 | 58 |
ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |
Supplier | Advantage |
---|---|
Wuhan Topule Biopharmaceutical Co., Ltd | 58 |
Aladdin Scientific | 58 |
BOC Sciences | 65 |
MedBioPharmaceutical Technology Inc | 58 |
Energy Chemical | 58 |
Nantong QuanYi Biotechnology Co., Ltd | 58 |
ApexBio Technology | 58 |