ChemicalBook >> CAS DataBase List >>LOR-253)
LOR-253)
- CAS No.
- 1422826-80-9
- Chemical Name:
- LOR-253)
- Synonyms
- APTO-253 isomer;APTO-253 (APTO253;1H-Imidazo[4,5-f][1,10]phenanthroline, 2-(6-fluoro-2-methyl-1H-indol-3-yl)-
- CBNumber:
- CB04844471
- Molecular Formula:
- C22H14FN5
- Molecular Weight:
- 367.38
- MDL Number:
- MOL File:
- 1422826-80-9.mol
Last updated:2023-03-31 09:12:58
LOR-253) Chemical Properties,Uses,Production
Description
APTO-253 isomer is an isomer of APTO-253 with the Fluoro-atom in 6-position. APTO-253 also known as LOR-253, LT-253, is a small molecule inhibitor of human metal-regulatory transcription factor 1 (MTF-1) with potential antitumor activity. MTF-1 inhibitor LOR-253 inhibits MTF-1 activity and thereby induces the expression of MTF-1 dependent tumor suppressor factor Kruppel like factor 4 (KLF4). This subsequently leads to the downregulation of cyclin D1, blocking cell cycle progression and proliferation. This agent also causes decreased expression of genes involved in tumor hypoxia and angiogenesis.
LOR-253) Preparation Products And Raw materials
Raw materials
Preparation Products
LOR-253) Suppliers
Global( 3)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 28118 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 12007 | 58 |
| Supplier | Advantage |
|---|---|
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 58 |
| TargetMol Chemicals Inc. | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 58 |
APTO-253
(APTO253
1H-Imidazo[4,5-f][1,10]phenanthroline, 2-(6-fluoro-2-methyl-1H-indol-3-yl)-
APTO-253 isomer
1422826-80-9