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FASCAPLYSIN CHLORIDE

CAS No.
114719-57-2
Chemical Name:
FASCAPLYSIN CHLORIDE
Synonyms
fascaplysine;FASCAPLYSIN CHLORIDE;Fascaplysin chloride hydrate;Fascaplysin (chloride)|CDK4 inhibitor;Pyrido[1,2-a:3,4-b']diindol-5-ium, 12,13-dihydro-13-oxo-, chloride;12,13-dihydro-13-oxo-pyrido[1,2-a:3,4-b']diindol-5-ium,monochloride;Fascaplysine hydrate, Pyrido[1,2-a:3,4-b]diindol-5-ium,12,13-dihydro-13-oxo-, chloride (9CI)
CBNumber:
CB0503495
Molecular Formula:
C18H11ClN2O
Molecular Weight:
306.74574
MDL Number:
MFCD09752600
MOL File:
114719-57-2.mol
MSDS File:
SDS
Last updated:2023-05-18 11:31:17

FASCAPLYSIN CHLORIDE Properties

storage temp. 2-8°C
solubility Soluble in DMSO (up to 20 mg/ml) or in Water (up to 2 mg/ml)
form solid
color Dark red-brown
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.

SAFETY

Risk and Safety Statements

Hazard Codes  Xi,T
Risk Statements  36/37/38-61-45-20/21/22
Safety Statements  26-53-45-36/37/39

FASCAPLYSIN CHLORIDE price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 341251 Fascaplysin, Synthetic - CAS 114719-57-2 - Calbiochem 114719-57-2 1mg $140 2023-01-07 Buy
Cayman Chemical 21715 Fascaplysin (chloride) ≥95% 114719-57-2 1mg $49 2024-03-01 Buy
Cayman Chemical 21715 Fascaplysin (chloride) ≥95% 114719-57-2 5mg $193 2024-03-01 Buy
TRC F150013 FascaplysinChloride 114719-57-2 10mg $160 2021-12-16 Buy
Biorbyt Ltd orb573160 Fascaplysin (chloride)|CDK4 inhibitor 114719-57-2 1g $3580.2 2021-12-16 Buy
Product number Packaging Price Buy
341251 1mg $140 Buy
21715 1mg $49 Buy
21715 5mg $193 Buy
F150013 10mg $160 Buy
orb573160 1g $3580.2 Buy

FASCAPLYSIN CHLORIDE Chemical Properties,Uses,Production

Description

Fascaplysin (114719-57-2) is a novel marine natural product isolated from?Thorectandra sp.1?A potent and selective inhibitor of cyclin dependent kinase 4/cyclin D1 (IC50?= 0.35 μM) and is less selective for Cdk6/D1 (IC50?= 3.4 μM). Displays antiangiogenic acitivity.2?Fascaplysin displays high cytotoxic activity against small cell lung cancer cell lines acting via multiple mechanisms including topoisomerase I, DNA integrity and ROS.3

Uses

Fascaplysin Chloride is a selective CDK4/cyclin D1 inhibitor. Downregulates the PI3K pathway in cancer cells and also has an effect on erythrocytes and thrombosis.

References

1) Soni?et al. (2000),?Inhibition of cyclin-dependent kinase 4 (Cdk4) by fascaplysin, a marine natural product; Biochem. Biophys. Res. Commun.,?275?877 2) Lin?et al. (2007),?Fascaplysin, a selective CDK4 inhibitor, exhibit anti-angiogenic activity in vitro and in vivo; Cancer Chemother. Pharmacol.,?59?439 3) Hamilton?et al. (2014),?Cytotoxic effects of fascaplysin against small cell lung cancer cell lines; Mar. Drugs,?12?1377

FASCAPLYSIN CHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

FASCAPLYSIN CHLORIDE Suppliers

Global( 18)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
BeiJing Hwrk Chemicals Limted 0757-86329057 18934348241 sales4.gd@hwrkchemical.com China 14063 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9806 58
BOC Sciences -- info@bocsci.com USA 0 65
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9409 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11217 58
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44808 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24647 58
fascaplysine Fascaplysin chloride hydrate Fascaplysine hydrate, Pyrido[1,2-a:3,4-b]diindol-5-ium,12,13-dihydro-13-oxo-, chloride (9CI) FASCAPLYSIN CHLORIDE Fascaplysin (chloride)|CDK4 inhibitor 12,13-dihydro-13-oxo-pyrido[1,2-a:3,4-b']diindol-5-ium,monochloride Pyrido[1,2-a:3,4-b']diindol-5-ium, 12,13-dihydro-13-oxo-, chloride 114719-57-2 C18H11ClN2OxH2O C18H11ClN2O