FASCAPLYSIN CHLORIDE
- CAS No.
- 114719-57-2
- Chemical Name:
- FASCAPLYSIN CHLORIDE
- Synonyms
- fascaplysine;FASCAPLYSIN CHLORIDE;Fascaplysin chloride hydrate;Fascaplysin (chloride)|CDK4 inhibitor;Fascaplysin, ATP-competitve CDK4 inhibitor;Pyrido[1,2-a:3,4-b']diindol-5-ium, 12,13-dihydro-13-oxo-, chloride;12,13-dihydro-13-oxo-pyrido[1,2-a:3,4-b']diindol-5-ium,monochloride;Fascaplysine hydrate, Pyrido[1,2-a:3,4-b]diindol-5-ium,12,13-dihydro-13-oxo-, chloride (9CI)
- CBNumber:
- CB0503495
- Molecular Formula:
- C18H11ClN2O
- Molecular Weight:
- 306.74574
- MDL Number:
- MFCD09752600
- MOL File:
- 114719-57-2.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Hazard Codes | Xi,T |
|---|---|
| Risk Statements | 36/37/38-61-45-20/21/22 |
| Safety Statements | 26-53-45-36/37/39 |
FASCAPLYSIN CHLORIDE price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 341251 | Fascaplysin, Synthetic - CAS 114719-57-2 - Calbiochem | 114719-57-2 | 1mg | $140 | 2023-01-07 | Buy |
| Cayman Chemical | 21715 | Fascaplysin (chloride) ≥95% | 114719-57-2 | 1mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 21715 | Fascaplysin (chloride) ≥95% | 114719-57-2 | 5mg | $193 | 2024-03-01 | Buy |
| TRC | F150013 | FascaplysinChloride | 114719-57-2 | 10mg | $160 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb573160 | Fascaplysin (chloride)|CDK4 inhibitor | 114719-57-2 | 1g | $3580.2 | 2021-12-16 | Buy |
FASCAPLYSIN CHLORIDE Chemical Properties,Uses,Production
Description
Fascaplysin (114719-57-2) is a novel marine natural product isolated from?Thorectandra sp.1?A potent and selective inhibitor of cyclin dependent kinase 4/cyclin D1 (IC50?= 0.35 μM) and is less selective for Cdk6/D1 (IC50?= 3.4 μM). Displays antiangiogenic acitivity.2?Fascaplysin displays high cytotoxic activity against small cell lung cancer cell lines acting via multiple mechanisms including topoisomerase I, DNA integrity and ROS.3
Uses
Fascaplysin Chloride is a selective CDK4/cyclin D1 inhibitor. Downregulates the PI3K pathway in cancer cells and also has an effect on erythrocytes and thrombosis.
References
1) Soni?et al. (2000),?Inhibition of cyclin-dependent kinase 4 (Cdk4) by fascaplysin, a marine natural product; Biochem. Biophys. Res. Commun.,?275?877 2) Lin?et al. (2007),?Fascaplysin, a selective CDK4 inhibitor, exhibit anti-angiogenic activity in vitro and in vivo; Cancer Chemother. Pharmacol.,?59?439 3) Hamilton?et al. (2014),?Cytotoxic effects of fascaplysin against small cell lung cancer cell lines; Mar. Drugs,?12?1377
FASCAPLYSIN CHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
FASCAPLYSIN CHLORIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| BeiJing Hwrk Chemicals Limted | 0757-86329057 18934348241 | sales4.gd@hwrkchemical.com | China | 14063 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9409 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44806 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24644 | 58 |