PKI 166 hydrochloride

Biological Activity

PKI-166 hydrochloride is a potent, selective, and orally bioactive EGFR tyrosine kinase inhibitor with IC50 of 0.7 nM.

in vivo

PKI-166 hydrochloride (100 mg/kg; po; daily; for 29 days) inhibits of pancreatic cancer growth.

Animal Model: < /td>	Male athymic nude mice with L3.6pl cells xenograft (8-12 weeks)
Dosage: < /td>	100 mg/kg
Administration:	Oral administration; daily; for 29 days
Result:	Significantly decreased median tumor volume.

target

IC50: 0.7 nM (EGFR tyrosine kinase)

storage

Store at +4°C

Raw materials

Preparation Products