ChemicalBook >> CAS DataBase List >>CHOLERA TOXIN
CHOLERA TOXIN
- CAS No.
- 9012-63-9
- Chemical Name:
- CHOLERA TOXIN
- Synonyms
- Cholergen;choleragen;CHOLERA TOXIN;Choleragenoid;choleraexotoxin;exo-enterotoxin;Toxins, cholera;CHOLERA ENTEROTOXIN;VIBRIO CHOLERAE TOXIN;choleraentero-exotoxin
- CBNumber:
- CB0683337
- Molecular Formula:
- NULL
- Molecular Weight:
- 0
- MDL Number:
- MFCD00130776
- MOL File:
- Mol file
Last updated:2024-07-02 08:54:58
| storage temp. | 0-6°C |
|---|---|
| solubility | H2O: soluble10mg/mL |
| form | lyophilized powder |
| color | White to off-white |
| FDA UNII | SJ4QUS6E3E |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H300+H310-H332-H412 |
| Precautionary statements | P262-P273-P280-P301+P310-P302+P352+P310-P304+P340+P312 |
| Hazard Codes | T |
| Risk Statements | 24/25-52/53 |
| Safety Statements | 36/37-45-61 |
| RIDADR | 3172 |
| WGK Germany | 2 |
| RTECS | LF3100000 |
| HazardClass | 6.1 |
| PackingGroup | I |
| Toxicity | cholera toxin is secreted by the gram-negative bacterium Vibrio cholerae. It is a gastrointestinal toxin that increases adenylate cyclase activity of mucosa of the small intestine, thereby increasing cyclic AMP within these cells. Cyclic AMP stimulates active transport of ions by these epithelial cells, resulting in a large efflux of Na+ and water into the gut. The toxin enters cells by interacting with a GM1 ganglioside on the cell surface. After entry, the A1 subunit catalyzes the transfer of an ADP-ribose unit from NAD+ to an arginine side chain of the adenylate cyclase regulatory G protein, blocking its GTPase activity. Thus the adenylate cyclase deactivation mechanism is destroyed, and cyclic AMP is continually produced. The major sign of cholera poisoning is severe diarrhea; several liters of body water may be lost within a few hours, leading to shock and death if fluid is not replaced. Treatment involves physiological support (including i.v. fluids) and antibiotics. |
CHOLERA TOXIN price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C8052 | Cholera Toxin from Vibrio cholerae ≥90% (SDS-PAGE), lyophilized powder | 9012-63-9 | 0.5mg | $171 | 2024-03-01 | Buy |
| Sigma-Aldrich | C8052 | Cholera Toxin from Vibrio cholerae ~95% (SDS-PAGE) | 9012-63-9 | 1mg | $296 | 2024-03-01 | Buy |
| Sigma-Aldrich | 227036 | CholeraToxin,Vibriocholerae,TypeInaba569B,AzideFree-CAS9012-63-9-Calbiochem CholeratoxinInaba569B,CAS9012-63-9,hasasingleAsubunitsurroundedbyfi | 9012-63-9 | 1mg | $297 | 2024-03-01 | Buy |
| Cayman Chemical | 23217 | Cholera Toxin from Vibrio cholerae ≥95% (estimated by SDS-PAGE) | 9012-63-9 | 2mg | $357 | 2021-12-16 | Buy |
| Cayman Chemical | 23217 | Cholera Toxin from Vibrio cholerae ≥95% (estimated by SDS-PAGE) | 9012-63-9 | 1mg | $188 | 2021-12-16 | Buy |
CHOLERA TOXIN Chemical Properties,Uses,Production
Uses
Cholera Toxin from Vibrio cholerae has been used as a positive control in cAMP (cyclic AMP) assay for enterotoxins. It has been added as a supplement in cell culture media of primary tumors and epithelial cells.
Biochem/physiol Actions
Toxin consisting of an A subunit (27 kDa) surrounded by five B subunits (approximately 12 kDa each), which attach the toxin to ganglioside GM1 on the cell surface. The A subunit catalyzes ADP-ribosylation of the α-subunit of the stimulatory G protein (Gαs), reducing GTPase activity and activating the α-subunit. This activation of Gαs leads to an increase in the activity of adenylyl cyclase, resulting in increased levels of cAMP. Also ADP-ribosylates transducin in the eye rod outer segments, inactivating its GTPase activity. Cholera toxin has also been reported to ADP-ribosylate tubulin. Shown to be a potent mucosal vaccine adjuvant, inducing T helper cell type 2 responses by inhibiting the production of interleukin-12.
CHOLERA TOXIN Preparation Products And Raw materials
Raw materials
Preparation Products
CHOLERA TOXIN Suppliers
Global( 47)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30241 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52925 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 |
| Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 | sj_scrc@sinopharm.com | China | 9815 | 79 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51456 | 80 |
| Beijing OKA biological technology co., LTD | 010-010-010-62971590 18548936886 | jack@oka-vip.com | China | 6897 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29774 | 58 |
9012-63-9(CHOLERA TOXIN)Related Search:
Choleragenoid
Cholera Toxin from Vibrio cholerae,Cholera enterotoxin, Cholergen
Cholergen
CHOLERA TOXIN
CHOLERA ENTEROTOXIN
CHOLERA TOXIN, VIBRIO CHOLERAE, TYPE INABA 569B
VIBRIO CHOLERAE TOXIN
choleraentero-exotoxin
choleraexotoxin
choleragen
exo-enterotoxin
exotoxin,vibriocholerae
CHOLERA TOXIN FROM VIBRIO CHOLERAE
Toxins, cholera
9012-63-9
G Protein Function
G Proteins and Cyclic Nucleotides
Reagents
BioChemical
Cell Signaling and Neuroscience
Cell Biology