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Y-27632 DIHYDROCHLORIDE

Y-27632 DIHYDROCHLORIDE Structure
Y-27632 DIHYDROCHLORIDE structure
CAS No.
146986-50-7
Chemical Name:
Y-27632 DIHYDROCHLORIDE
Synonyms
Y-27632;ROCK INHIBITOR;Y-276322HCl;Rock inhibitor y-27632;(1R,4R)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide;CS-20;Y-27632/Y27632;Y-27632 (2HCl),98%;Y-27632, free base;Y-27632 dihydrochlor
CBNumber:
CB0699488
Molecular Formula:
C14H21N3O
Molecular Weight:
247.34
MDL Number:
MFCD03490488
MOL File:
146986-50-7.mol
MSDS File:
SDS
Last updated:2025-04-28 21:36:36
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Y-27632 DIHYDROCHLORIDE Properties

Melting point >260°C (dec.)
Boiling point 462.6±15.0 °C(Predicted)
Density 1.136±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility H2O: 14 mg/mL
pka 13.53±0.40(Predicted)
form solid
color white
Stability Hygroscopic
FDA UNII 0X370ROP6H
UNSPSC Code 12352207
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H312-H332
Precautionary statements  P280
Hazard Codes  Xn
Risk Statements  20/21/22
Safety Statements  36
WGK Germany  3

Y-27632 DIHYDROCHLORIDE price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 5.09228 InSolution Y-27632, Sterile-Filtered, Cell Culture-Tested - CAS 146986-50-7 - Calbiochem 146986-50-7 2mg $378 2024-03-01 Buy
Sigma-Aldrich 688000 Y-27632 - CAS 146986-50-7 - Calbiochem 146986-50-7 1MG $238 2023-01-07 Buy
Sigma-Aldrich 688000 Y-27632 - CAS 146986-50-7 - Calbiochem 146986-50-7 5MG $894 2023-01-07 Buy
Sigma-Aldrich 688000 Y-27632 - CAS 146986-50-7 - Calbiochem 146986-50-7 10MG $1200 2023-01-07 Buy
Sigma-Aldrich 688000 Y-27632 - CAS 146986-50-7 - Calbiochem 146986-50-7 100MG $2170 2023-01-07 Buy
Product number Packaging Price Buy
5.09228 2mg $378 Buy
688000 1MG $238 Buy
688000 5MG $894 Buy
688000 10MG $1200 Buy
688000 100MG $2170 Buy

Y-27632 DIHYDROCHLORIDE Chemical Properties,Uses,Production

Uses

Y-27632 Dihydrochloride is a salt analog of Y-27632, which is Rho-kinase inhibitor.

Definition

ChEBI: A monocarboxylic acid amide that is trans-[(1R)-1-aminoethyl]cyclohexanecarboxamide in which one of the nitrogens of the aminocarbony group is substituted by a pyridine nucleus. It has been shown to exhibit inhibitory acti ity against Rho-associated protein kinase (ROCK) enzyme.

Biological Activity

Selective inhibitor of the Rho-associated protein kinase p160ROCK. K i values are 0.14, 26, 25 and >250 μ M for p160ROCK, PKC, cAMP-dependent protein kinase and myosin light-chain kinase respectively. Also inhibits the protein kinase C-related protein kinase, PRK2 (IC 50 = 600nM). Smooth muscle relaxant and orally active in vivo . Increases survival rate of human embryonic stem (hES) cells undergoing cryopreservation.

in vivo

Y-27632 (5 and 10 mg/kg) significantly prolongs the onset time of myoclonic jerks when compare with saline group. Y-27632 (5 and 10 mg/kg) significantly prolongs the onset time of clonic convulsions when compare with saline group[3]. Treatment with Dimethylnitrosamine (DMN) causes a significant decrease in rat body and liver weight (DMN-S group) compared with control animals (S-S group). Oral Y27632 (30 mg/kg) essentially prevents this DMN-induced rat body and liver weight loss (DMN-Y group)[4].

IC 50

ROCK-I: 220 nM (Ki); ROCK-II: 300 nM (Ki); PKN: 3.1 μM (Ki); Citron kinase: 5.3 μM (Ki); PKCα: 73 μM (Ki); PKA: 25 μM (Ki)

References

[1] ishizaki t1, uehata m, tamechika i, keel j, nonomura k, maekawa m, narumiya s. pharmacological properties of y-27632, a specific inhibitor of rho-associated kinases. mol pharmacol. 2000 may;57(5):976-83.

Y-27632 DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

Y-27632 DIHYDROCHLORIDE Suppliers

Global( 185)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 965 58
Shandong chuangyingchemical Co., Ltd. 		18853181302 sale@chuangyingchem.com CHINA 5906 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49732 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29808 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32222 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
AFINE CHEMICALS LIMITED 		+86-0571-85134551 sales@afinechem.com China 15416 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9911 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Biochempartner 		58
Shandong chuangyingchemical Co., Ltd. 		58
BOC Sciences 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
AFINE CHEMICALS LIMITED 		58
Hefei Hirisun Pharmatech Co., Ltd 		58

View Lastest Price from Y-27632 DIHYDROCHLORIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Y-27632 pictures 2025-04-28 Y-27632
146986-50-7
 US $39.00-98.00 / mg 99.87% 10g TargetMol Chemicals Inc.
Y-27632 DIHYDROCHLORIDE pictures 2020-01-08 Y-27632 DIHYDROCHLORIDE
146986-50-7
 US $2.00 / KG 1g 98%MIN ASK Career Henan Chemical Co
  • Y-27632 pictures
  • Y-27632
    146986-50-7
  • US $39.00-98.00 / mg
  • 99.87%
  • TargetMol Chemicals Inc.

Y-27632 DIHYDROCHLORIDE Spectrum

Y-27632 DIHYDROCHLORIDE(146986-50-7)1HNMR

146986-50-7(Y-27632 DIHYDROCHLORIDE)Related Search:

Y-27632 (2HCl), 5 mg Y6 Y27632 (hydrochloride) N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE Y320
(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide (R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride (R)-(+)-3-Butyn-2-ol (R)-(1-(4-nitrophenyl))ethanol Y-27632 DIHYDROCHLORIDE
1,4-Cyclohexanebis(methylamine)

1of3

(R)-(+)-TRANS-N-(4-PYRIDYL)-4-(1-AMINOETHYL)-CYCLOHEXANECARBOXAMIDE 2HCL (R)-(+)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL)CYCLOHEXANECARBOXAMIDE DIHYDROCHLORIDE (+)-R-TRANS-4-(AMINOETHYL)-N-(4-PYRIDYL)-CYCLOHEXANECARBOXAMIDE 2HCL H2O Y-27632 DIHYDROCHLORIDE TRANS-4-[(1R)-1-AMINOETHYL]-N-4-PYRIDINYLCYCLOHEXANECARBOXAMIDE DIHYDROCHLORIDE 4-[(1R)-1-Aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide dihydrochloride (1R,4r)-4-((R)-1-aMinoethyl)-N-(pyridin-4-yl)cyclohexanecarboxaMide dihydrochloride CyclohexanecarboxaMide,4-[(1R)-1-aMinoethyl]-N-4-pyridinyl-, trans- Y-27632/Y27632 Y-27632, Free Base, >99% (+)-Trans-4-[1(r)-aminoethyl]-n-(4-pyridyl)cyclohexane-1-carboxamide Y-27632 (2HCl),98% Y-27632, free base 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-trans-cyclohexanecarboxamide 4-[(1R)-1-Aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide (1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexane-1-carboxamide dihydrochloride 4-[(1R)-1-Aminoethyl]-N-(4-pyridinyl)cyclohexanecarboxamide CS-20 4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexane-1-carboxamide (+)-(R)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide (1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4(1H)-ylidene)cyclohexanecarboxamide Y-27632 dihydrochlor ROCK INHIBITOR Y-27632 Y-276322HCl (1R,4R)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide Rock inhibitor y-27632 trans-4-((R)-1-Aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide trans-4-((R)-1-Aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide , Y-27632 Y-27632, 10 mM in DMSO 146986-50-7 BioChemical Cell Biology Cell Signaling and Neuroscience Kinase/Phosphatase Biology Rho Kinase (ROCK) Serine/Threonine Kinase Inhibitors Inhibitors Protein Kinase Signalling Inhibitor APIs SiChem