(+)-ALPHA-DIHYDROTETRABENAZINE
- CAS No.
- 3466-75-9
- Chemical Name:
- (+)-ALPHA-DIHYDROTETRABENAZINE
- Synonyms
- DTBZ;DIHYDROTETRABENAZINE;Hydroxy Tetrabenazine;(+)-ALPHA-DIHYDROTETRABEZINE;(+)-ALPHA-DIHYDROTETRABENAZINE;Hydroxy Tetrabenazine - Mixture of cis and trans Isomers;2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-;2H-BENZO[A]QUINOLIZINE-2-OL, 1,3,4,6,7,11B-HEXAHYDRO-3-ISOBUTYL-9,10-DIMETHOXY-;9,10-dimethoxy-3-(2-methylpropyl)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-ol;1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol
- CBNumber:
- CB0716932
- Molecular Formula:
- C19H29NO3
- Molecular Weight:
- 319.44
- MDL Number:
- MFCD20275194
- MOL File:
- 3466-75-9.mol
| Boiling point | 457.8±45.0 °C(Predicted) |
|---|---|
| Density | 1.13±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Chloroform: soluble; Methanol: soluble |
| form | A solid |
| pka | 14.75±0.40(Predicted) |
| CAS DataBase Reference | 3466-75-9 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| NFPA 704 |
|
(+)-ALPHA-DIHYDROTETRABENAZINE price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27182 | Dihydrotetrabenazine | 3466-75-9 | 500μg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 27182 | Dihydrotetrabenazine | 3466-75-9 | 1mg | $230 | 2024-03-01 | Buy |
| TRC | H627630 | HydroxyTetrabenazine-MixtureofcisandtransIsomers | 3466-75-9 | 100mg | $175 | 2021-12-16 | Buy |
| AK Scientific | Z3455 | trans-Dihydrotetrabenazine | 3466-75-9 | 1mg | $353 | 2021-12-16 | Buy |
| Chemtos | T-6836 | 2-alpha-DihydrotetrabenazineLabeledd7 | 3466-75-9 | 10mg | $2375 | 2021-12-16 | Buy |
(+)-ALPHA-DIHYDROTETRABENAZINE Chemical Properties,Uses,Production
Description
Dihydrotetrabenazine is an active metabolite of the vesicular monoamine transporter 2 (VMAT2) inhibitor tetrabenazine that is generated by hepatic carbonyl reductases. Dihydrotetrabenazine binds to mouse pons medulla, hypothalamus, and striatum (Kds = 2.72, 2.28, and 2.4 nM, respectively) and inhibits synaptic vesicular serotonin (5-HT) uptake (IC50s = 2.2, 2.8, and 2.3 nM, respectively). It also binds to human caudate nucleus, hippocampus, and substantia nigra pars compacta (Kds = 2.9, 2.5, and 2.8 nM, respectively). Dihydrotetrabenazine stereoisomers bind to VMAT2 in rat striatum.
Chemical Properties
Colourless solid
Uses
Dihydrotetrabenazine (DHTBZ) is the active metabolite of Tetrabenazine (HY-B0590). Dihydrotetrabenazine is the inhibitor for human vesicular monoamine transporter 2 (VMAT2), that reduces monoamine content in presynaptic neurons, and can be used in movement disorder research[1].
Definition
ChEBI: B-Dihydrotetrabenazine is a member of isoquinolines.
References
[1] Chen JJ, et al., Tetrabenazine for the treatment of hyperkinetic movement disorders: a review of the literature. Clin Ther. 2012 Jul;34(7):1487-504. DOI:10.1016/j.clinthera.2012.06.010
(+)-ALPHA-DIHYDROTETRABENAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
(+)-ALPHA-DIHYDROTETRABENAZINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | 1057@dideu.com | China | 3922 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20235 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 | |
| Daicel Chiral Technologies (China)CO.,LTD | 021-50460086-9 15921403865 | han_yajun@dctc.daicel.com | China | 6576 | 65 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| ChemStrong Scientific Co.,Ltd | 0755-0755-66853366 13670046396 | sales@chem-strong.com | China | 18146 | 56 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9923 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
View Lastest Price from (+)-ALPHA-DIHYDROTETRABENAZINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-08-02 | (+)-ALPHA-DIHYDROTETRABENAZINE
3466-75-9
|
US $0.10 / KG | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd |
-
- (+)-ALPHA-DIHYDROTETRABENAZINE
3466-75-9
- US $0.10 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd