CGP 55845
- CAS No.
- 149184-22-5
- Chemical Name:
- CGP 55845
- Synonyms
- CGP 55845;CGP 55845 hydrochlor;CGP 55845 hydrochloride;benzyl-[(2S)-3-[[(1S)-1-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropyl]phosphinic acid;(2S)-3-[[(1S)-1-(3,4-DICHLOROPHENYL)ETHYL]AMINO-2-HYDROXYPROPYL](PHENYLMETHYL)PHOSPHINIC ACID;(2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino-2-hydroxypropyl](phenylmethyl)phosphinicacidhydrochloride
- CBNumber:
- CB0718390
- Molecular Formula:
- C18H23Cl3NO3P
- Molecular Weight:
- 438.71
- MDL Number:
- MOL File:
- 149184-22-5.mol
- MSDS File:
- SDS
CGP 55845 price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0594 | CGP 55845 hydrochloride ≥98% (HPLC) | 149184-22-5 | 5mg | $134 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0594 | CGP 55845 hydrochloride ≥98% (HPLC) | 149184-22-5 | 25mg | $539 | 2024-03-01 | Buy |
| Tocris | 1248 | CGP 55845 hydrochloride ≥98%(HPLC) | 149184-22-5 | 50 | $942 | 2021-12-16 | Buy |
| Tocris | 1248 | CGP 55845 hydrochloride ≥98%(HPLC) | 149184-22-5 | 10 | $225 | 2021-12-16 | Buy |
| TRC | C291770 | CGP 55845 hydrochloride | 149184-22-5 | 100mg | $1040 | 2021-12-16 | Buy |
CGP 55845 Chemical Properties,Uses,Production
Uses
CGP is a potent, selectie GABAB receptor antagonist.
Biological Activity
Potent, selective GABA B receptor antagonist (IC 50 = 5 nM) that prevents agonist binding (pK i = 8.35) and inhibits GABA and glutamate release (pEC 50 values are 8.08 and 7.85 respectively). Inhibits GABA B responses to baclofen (IC 50 = 130 nM in an isoproterenol assay) and potentiates the hypoglycemic response to glucose in vitro .
Biochem/physiol Actions
CGP 55845 is a potent selective GABA-B receptor antagonist with an IC50 of 5 nM.
in vitro
antagonist cgp 55845a of the gabab receptor in the presence of cnqx and d(2)-2-amino-5-phosphonovaleric acid prevented the inhibitory postsynaptic potential-b and paired-pulse depression. [3].
IC 50
5 nm
storage
Room temperature
References
[1] waldmeier pc, wicki p, feldtrauer jj, mickel sj, bittiger h, baumann pa. gaba and glutamate release affected by gabab receptor antagonists with similar potency: no evidence for pharmacologically different presynaptic receptors. br j pharmacol. 1994 dec;113(4):1515-21.
[2] cunningham md, enna sj. evidence for pharmacologically distinct gabab receptors associated with camp production in rat brain. brain res. 1996 may 13;720(1-2):220-4.
[3] deisz ra. the gaba(b) receptor antagonist cgp 55845a reduces presynaptic gaba(b) actions in neocortical neurons of the rat in vitro. neuroscience. 1999;93(4):1241-9.
[4] zhang m, buttigieg j, nurse ca. neurotransmitter mechanisms mediating low-glucose signalling in cocultures and fresh tissue slices of rat carotid body. j physiol. 2007 feb 1;578(pt 3):735-50. epub 2006 nov 23.
[5] salah a, perkins kl. effects of subtype-selective group i mglur antagonists on synchronous activity induced by 4-aminopyridine/cgp 55845 in adult guinea pig hippocampal slices. neuropharmacology. 2008 jul;55(1):47-54. doi: 10.1016/j.neuropharm.2008.04.010. epub 2008 apr 23.
CGP 55845 Preparation Products And Raw materials
Raw materials
Preparation Products
CGP 55845 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52925 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51456 | 80 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44808 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8140 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 13774214275 | zhouzz@univ-bio.com | China | 24990 | 58 |
| Xi'an Qiyue Biotechnology Co., Ltd. | 400-400-6966-012-012 17778955912 | 2957605606@qq.com | China | 2535 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4933 | 58 |