4,4'-Thiobis(6-tert-butyl-m-cresol)
- CAS No.
- 96-69-5
- Chemical Name:
- 4,4'-Thiobis(6-tert-butyl-m-cresol)
- Synonyms
- Santonox;Rutenol;Sumilizer WX-R;Antioxidant 300;AN 300;AO-300;usafb-15;ST029248;nocrac300;USAF B-15
- CBNumber:
- CB0722795
- Molecular Formula:
- C22H30O2S
- Molecular Weight:
- 358.54
- MDL Number:
- MFCD00026287
- MOL File:
- 96-69-5.mol
- MSDS File:
- SDS
| Melting point | 160-165 °C |
|---|---|
| Boiling point | 460.94°C (rough estimate) |
| Density | 1.06~1.12g/cm3 |
| vapor pressure | 0.001Pa at 20℃ |
| refractive index | 1.5200 (estimate) |
| Flash point | 215 °C |
| storage temp. | Store below +30°C. |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 10.76±0.36(Predicted) |
| form | Fine white to gray powder. |
| color | White to Off-White |
| Water Solubility | <0.01 g/100 mL at 18 ºC |
| Stability | Stable under recommended storage conditions., Stable Under Recommended Storage C |
| InChIKey | HXIQYSLFEXIOAV-UHFFFAOYSA-N |
| LogP | 5.24 at 25℃ |
| CAS DataBase Reference | 96-69-5(CAS DataBase Reference) |
| Indirect Additives used in Food Contact Substances | 4,4'-THIOBIS(6-TERT-BUTYL-M-CRESOL) |
| FDA 21 CFR | 175.105; 177.2600; 178.2010 |
| FDA UNII | 3CA5G9822V |
| NIST Chemistry Reference | 4,4'-Thiobis(3-methyl-6-t-butylphenol)(96-69-5) |
| EPA Substance Registry System | 4,4'-Thiobis(6-tert-butyl-m-cresol) (96-69-5) |
| UNSPSC Code | 41116107 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H317-H410 | |||||||||
| Precautionary statements | P261-P272-P273-P280-P302+P352-P333+P313 | |||||||||
| Hazard Codes | Xi,N | |||||||||
| Risk Statements | 36/37/38-50/53-43 | |||||||||
| Safety Statements | 37/39-26-61-60-36/37-24/25 | |||||||||
| OEB | B | |||||||||
| OEL | TWA: 10 mg/m3 (total) | |||||||||
| WGK Germany | WGK 2 water endangering | |||||||||
| RTECS | GP3150000 | |||||||||
| Autoignition Temperature | 402 °C | |||||||||
| HS Code | 29309070 | |||||||||
| Hazardous Substances Data | 96-69-5(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 orally in Rabbit: 2345 mg/kg | |||||||||
| NFPA 704 |
|
4,4'-Thiobis(6-tert-butyl-m-cresol) price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.18449 | 4,4′-Thiobis(2-tert-butyl-5-methylphenol) for synthesis | 96-69-5 | 100g | $71.1 | 2024-03-01 | Buy |
| Sigma-Aldrich | 90557 | 4,4′-Thiobis(2-tert-butyl-5-methylphenol) analytical standard | 96-69-5 | 100MG | $75.1 | 2022-05-15 | Buy |
| TCI Chemical | T0196 | 4,4'-Thiobis(6-tert-butyl-m-cresol) >98.0%(GC) | 96-69-5 | 25g | $30 | 2024-03-01 | Buy |
| TCI Chemical | T0196 | 4,4'-Thiobis(6-tert-butyl-m-cresol) >98.0%(GC) | 96-69-5 | 100g | $56 | 2024-03-01 | Buy |
| TCI Chemical | T0196 | 4,4'-Thiobis(6-tert-butyl-m-cresol) >98.0%(GC) | 96-69-5 | 500g | $163 | 2024-03-01 | Buy |
4,4'-Thiobis(6-tert-butyl-m-cresol) Chemical Properties,Uses,Production
Description
4,4'-Thiobis(6-tert-butyl-m-cresol) (Antioxidant 300), melting point 161-163℃, white powder, low volatility, low toxicity; soluble in organic solvents such as benzene, toluene, acetone, methanol, ethanol, carbon tetrachloride, slightly soluble in petroleum solvents, insoluble in water, is a non-polluting, high-efficiency phenolic antioxidant with low volatility, high antioxidant efficiency, good thermal stability and weather resistance, and little effect on the electrical properties of the product. It also has a synergistic effect when used with carbon black and octadecyl alcohol. It can be used as an antioxidant for polypropylene, ABS, polystyrene, polyphthalamide, polyurethane, etc., and is suitable for white, bright-colored and transparent products. It has very low toxicity and is allowed to be used in plastic products that come into contact with food in many countries.
Chemical Properties
4,40-Thiobis(6-tert-butyl-m-cresol) is a light gray to tan powder. Aromatic odor.
Chemical Properties
white to almost white crystals or crystalline
Uses
4,4''-Thiobis(2-tert-butyl-5-methylphenol) is an antioxidant in the rubber and plastics industry. 4,4''-Thiobis(2-tert-butyl-5-methylphenol) is a radical inhibitor which prevents the thermal decomposition of the peracid. In addition, it is used as a stabilizer in polyethylene and polyolefin packaging materials for foodstuffs. Protection of light-colored rubber from oxidation and of nonstaining neoprene compounds against deterioration.
General Description
White or light gray to tan powder.
Air & Water Reactions
Sensitive to base hydrolysis and may spontaneously oxidize in solution. . Insoluble in water.
Reactivity Profile
4,4'-Thiobis(6-tert-butyl-m-cresol) may be sensitive to light.
Hazard
Toxic by inhalation. Upper respiratory tract irritant. Questionable carcinogen.
Health Hazard
4,4'-Thiobis(6-tert-butyl-mcresol) (TBBC) is of low systemic toxicity in animals; allergic contact dermatitis has been reported in humans.
Fire Hazard
4,4'-Thiobis(6-tert-butyl-m-cresol) is combustible.
Flammability and Explosibility
Non flammable
Safety Profile
Poison by intraperitoneal route and probably by ingestion and inhalation. Mutation data reported. See also SULFIDES. When heated to decomposition it emits highly toxic fumes of SOx.
Synthesis
2-tert-butyl-5-methylphenol (164.2, 1.0mol), silver nitrate (169.9, 1.0mol), iodine (253.8g, 1.0mol) and dichloromethane 0.7L is added to the reactor, stirred at room temperature under light-proof conditions, and the colour of iodine gradually disappears, accompanied by the generation of silver iodide. After 30 min, the generated silver iodide is filtered and recovered, and the filtrate is washed with 1.1L water and recycled for washing Water. After the organic phase is dried with industrial anhydrous magnesium sulfate, Cu (8.2g), thiourea (38.1g, 0.5mol) and triethylamine 200g (about 273ml) are added inside and then reacted for 4 hours under reflux. After the reaction terminates, it is naturally cooled to room temperature, and the Cu catalyst is filtered and recovered; then water is added for dilution and washing, and after separating the aqueous phase, the organic phase is added with water again, and the pH is adjusted to 6-7 with phosphoric acid, and the aqueous phase is separated after standing. The organic phase was washed with saturated sodium chloride aqueous solution and water, respectively, dried with industrial magnesium sulfate, distilled under reduced pressure, and dichloromethane was recovered, then recrystallized with ethanol. 159.5 g of 4,4′-thiobis(6-tert-butyl-3-methylphenol) was obtained.
Potential Exposure
This material is used as an antioxidant in the plastics and rubber industries; in Neoprene and other synthetic rubbers; in polyethylene and polypropylene.
Carcinogenicity
TBBC was not mutagenic in Salmonella typhimurium strains with or without metabolic activation. In Chinese hamster ovary cells, TBBC induced an increase in sister chromatid exchanges but there were no increases in chromosomal aberrations.
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. May evolve explosive hydrogen sulfide upon contact with moisture or acids.
4,4'-Thiobis(6-tert-butyl-m-cresol) Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| QINGDAO JADE NEW MATERIAL TECNOLOGY CO.,LTD | +86 13658692156 | zandrew@jadenmtc.com | China | 223 | 58 |
| Qingdao Truelight functional Material Technology Co., Ltd. | +86-13573844393 | songjames@truelightchem.com | China | 221 | 58 |
| HANGZHOU HAILAN CHEMICAL CO.,LTD. | +86-57156122185 +86-15967590394 | sales@hailan-chem.com | China | 297 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531157085 | abby@chuanghaibio.com | China | 8808 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12809 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5868 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18137 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| Hebei Shengyang Water Conservancy Engineering Co., Ltd. | +8615373025980 | clara@hbshengyang.com | China | 847 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-+86-371-66670886 | info@dakenam.com | China | 19805 | 58 |
View Lastest Price from 4,4'-Thiobis(6-tert-butyl-m-cresol) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-25 | Antioxidant 300
96-69-5
|
US $0.00 / KG | 1KG | 99% | 1000 KGS | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-04-23 | 4,4'-Thiobis(6-tert-butyl-m-cresol)
96-69-5
|
US $10.00 / KG | 1KG | 99% | 100 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-04-15 | Antioxidant 300
96-69-5
|
US $0.00-0.00 / KG | 1KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd |
-
- Antioxidant 300
96-69-5
- US $0.00 / KG
- 99%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 4,4'-Thiobis(6-tert-butyl-m-cresol)
96-69-5
- US $10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Antioxidant 300
96-69-5
- US $0.00-0.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd