ANTI-GUANYLATE CYCLASE A1
- CAS No.
- Chemical Name:
- ANTI-GUANYLATE CYCLASE A1
- Synonyms
- ANTI-GUANYLATE CYCLASE A1;Anti-Guanylyl Cyclase α1 antibody produced in rabbit
- CBNumber:
- CB0739898
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD03455075
- MOL File:
- Mol file
ANTI-GUANYLATE CYCLASE A1 price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | G4280 | Anti-Guanylyl Cyclase α1 antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution | 0.2mL | $241.2 | 2024-03-01 | Buy | |
Sigma-Aldrich | G4280 | Anti-Guanylyl Cyclase α1 antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution | 25μL | $147 | 2022-05-15 | Buy |
ANTI-GUANYLATE CYCLASE A1 Chemical Properties,Uses,Production
Uses
Anti-Guanylyl Cyclase α1 antibody produced in rabbit is suitable for immunohistochemistry at a working dilution of 1:100 using trypsin-treated human, bovine and mouse heart tissue and immunoprecipitation at 5-10μg concentration using 60-120μg of a cytosolic fraction of rat brain. It is also suitable for western blot analysis using cytosolic fraction of rat brain at a working dilution of 1:10,000.
It was used as a primary antibody for immunohistochemical:
- localization of α1 subunits of sGC (soluble guanylate cyclase) in the guinea pig gastrointestinal tract
- detection of expression of sGC in the vasculature of rat skeletal muscle
- localization of the functional subunit of NO receptors, sGCα1 in guinea pig caecum
General Description
The enzyme consists of α and β subunits of ~80kDa and ~70kDa respectively. Both the units are required for catalytic activity. The N-terminal domains of the subunits are essential for the stimulation of the enzyme by NO. Dimerization is mediated by the central portion of GC. The C-terminus domain of both subunits forms the catalytic domain.
Biochem/physiol Actions
Guanylyl cyclase (GC) catalyzes the conversion of guanosine-5′-triphosphate (GTP) to cyclic guanosine-3′,5-monophosphate (cGMP) and pyrophosphate. This reaction requires Mg2+ or Mn2+.
ANTI-GUANYLATE CYCLASE A1 Preparation Products And Raw materials
Raw materials
Preparation Products
ANTI-GUANYLATE CYCLASE A1 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Riedel-de Haen AG | -- | United States | 6825 | 87 | |
SIGMA-RBI | -- | Switzerland | 6913 | 91 |
Supplier | Advantage |
---|---|
Riedel-de Haen AG | 87 |
SIGMA-RBI | 91 |