ChemicalBook >> CAS DataBase List >>2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE

2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE

2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE structure

CAS No.: 526-36-3

Chemical Name:: 2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE

Synonyms: Otrix;Otriven;Otrivin;Ba-11391;Otrivine;Rhinoxilin;XYLOMETAZOLINE;Xylomethazoline;AKOS BBS-00000259;XYLOMETAZOLINEANDITSHYDROCHLORIDE

CBNumber:: CB0759137

Molecular Formula:: C16H24N2

Molecular Weight:: 244.38

MDL Number:: MFCD00242956

MOL File:: 526-36-3.mol

MSDS File:: SDS

Last updated:2025-04-17 18:22:24

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2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE Properties

Melting point	131-133°
Boiling point	394.2±21.0 °C(Predicted)
Density	1.00±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: 49 mg/mL (200.51 mM);Ethanol: 49 mg/mL (200.51 mM)
pka	pKa 10.6±0.1(H2O t = 22.0) (Uncertain)
Water Solubility	Water: Insoluble
CAS DataBase Reference	526-36-3
EWG's Food Scores	1
FDA UNII	WPY40FTH8K
ATC code	R01AA07,R01AB06,S01GA03,S01GA53

SAFETY

Risk and Safety Statements

Toxicity	LD50 oral in mouse: 215mg/kg

2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biosynth Carbosynth	FB147686	2-(4-tert-Butyl-2,6-dimethyl-benzyl)-4,5-dihydro-1H-imidazole	526-36-3	250mg	$97.5	2021-12-16	Buy
Biosynth Carbosynth	FB147686	2-(4-tert-Butyl-2,6-dimethyl-benzyl)-4,5-dihydro-1H-imidazole	526-36-3	500mg	$170	2021-12-16	Buy
Biosynth Carbosynth	FB147686	2-(4-tert-Butyl-2,6-dimethyl-benzyl)-4,5-dihydro-1H-imidazole	526-36-3	1g	$296	2021-12-16	Buy
American Custom Chemicals Corporation	API0004631	2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE 95.00%	526-36-3	1G	$339.15	2021-12-16	Buy
Biosynth Carbosynth	FB147686	2-(4-tert-Butyl-2,6-dimethyl-benzyl)-4,5-dihydro-1H-imidazole	526-36-3	2g	$514	2021-12-16	Buy

Product number	Packaging	Price	Buy
FB147686	250mg	$97.5	Buy
FB147686	500mg	$170	Buy
FB147686	1g	$296	Buy
API0004631	1G	$339.15	Buy
FB147686	2g	$514	Buy

2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE Chemical Properties,Uses,Production

Uses

Adrenergic (vasoconstrictor).

Uses

Xylometazoline is used for rhinitis, laryngitis, sinusitis, inflammation of antrum of Highmore, and allergic illnesses of the nasal cavity and throat.

Definition

ChEBI: Xylometazoline is an alkylbenzene.

brand name

Neo-Synephrine II (Sterling Winthrop); Otrivin Hydrochloride (Ciba-Geigy).

Synthesis

Xylometazoline, 2-(4-tert-butyl-2,6-dimethylbenzyl)-2-imidazoline (11.1.40), is also synthesized in a single reaction by cyclocondensation of 4-tert-butyl-2,6- dimethylbenzylcyanide with ethylendiamine [43,44].

Synthesis_526-36-3

in vivo

Xylometazoline (1 mg/mL, intranasal, single dose) improves sinusitis in rats^[3].
Xylometazoline and its excipients, when used for prolonged periods, may cause ophthalmic problems such as dry eyes, corneal edema, cataracts, retinal nerve fiber layer damage, and vascular damage^[4].

Animal Model:	SpragueDawley rat induced by platelet-activating factor^[3]
Dosage:	1 mg/mL; single dose
Administration:	Intranasal administration
Result:	Showed almost no vascular congestion, little infiltration, and the epithelium was completely intact.

IC 50

Alpha-1A adrenergic receptor: 0.05 μM (Ki); Alpha-1B adrenergic receptor: 0.30 μM (Ki); Alpha-1D adrenergic receptor: 0.15 μM (Ki); Alpha-2A adrenergic receptor: 0.88 μM (Ki); Alpha-2B adrenergic receptor: 1.7 μM (Ki); Alpha-2C adrenergic receptor: 0.19 μM (Ki)

2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE Suppliers

Global( 68)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21628	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29859	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49732	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22854	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15349	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52849	58
Zhuoer Chemical Co., Ltd	02120970332; +8613524231522	sales@zhuoerchem.com	China	2904	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3135	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38630	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49984	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
CONIER CHEM AND PHARMA LIMITED	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Zhuoer Chemical Co., Ltd	58
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58
GIHI CHEMICALS CO.,LIMITED	58

View Lastest Price from 2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-06-02	2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE USP/EP/BP 526-36-3	US $1.10 / g	1g	99.9%	100Tons min	Dideu Industries Group Limited
	2019-07-06	2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE 526-36-3	US $1.00 / KG	1G	98%	100KG	Career Henan Chemical Co

2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE USP/EP/BP
526-36-3
US $1.10 / g
99.9%
Dideu Industries Group Limited

2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE
526-36-3
US $1.00 / KG
98%
Career Henan Chemical Co

526-36-3(2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE)Related Search:

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Oxymetazoline hydrochloride 2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE Oxymetazoline Tolazoline 5-TERT-BUTYL-1,2,3-TRIMETHYLBENZENE

Xylometazoline hydrochloride 2-(4-BIPHENYL)ETHYLAMINE 2-(4-TERT-BUTYLPHENYL)ETHYLAMINE

1of4

XYLOMETAZOLINE 2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE AKOS BBS-00000259 XYLOMETAZOLINEANDITSHYDROCHLORIDE Xylometazoline (base and/or unspecified salts) 1h-imidazole,2-((4-(1,1-dimethylethyl)-2,6-dimethylphenyl)methyl)-4,5-dihydr 2-(4-tert-butyl-2,6-dimethylbenzyl)-2-imidazolin 2-(4-tert-Butyl-2,6-dimethylbenzyl)-2-imidazoline 2-[[4-(1,1-Dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro-1H-imidazole 2-Imidazoline, 2-(4-tert-butyl-2,6-dimethylbenzyl)- Ba-11391 Otriven Otrivin Otrivine Otrix Xylomethazoline 1H-Imidazole,2-[[4-(1,1-dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro- ORGANIC CHEMICAL - XYLOMETAZOLINE HYDROCHLOROTHIAZIDE Oxymetazoline Impurity 2（Oxymetazoline EP Impurity B） 2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazole 2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE USP/EP/BP Rhinoxilin 2-[[4-(1,1-dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro-1h-imidazole(xylometazoline), 526-36-3