4-Hydroxycoumarin
- CAS No.
- 1076-38-6
- Chemical Name:
- 4-Hydroxycoumarin
- Synonyms
- 4-HYDROXY-2H-CHROMEN-2-ONE;HydroxyCoumarin;4-Coumaryl alcohol;4-hydroxy-2h-1-benzopyran-2-on;COUMARINOL;4-HYDROXY-2H-1-BENZOPYRAN-2-ONE;4-Coumarinol;COUMARIN KIT;4-HydroxycouMa;4-HYDROXYCUMARIN
- CBNumber:
- CB0760607
- Molecular Formula:
- C9H6O3
- Molecular Weight:
- 162.14
- MDL Number:
- MFCD00006856
- MOL File:
- 1076-38-6.mol
- MSDS File:
- SDS
Melting point | 211-213 °C (lit.) |
---|---|
Boiling point | 228.82°C (rough estimate) |
Density | 1.1734 (rough estimate) |
vapor pressure | 0.02Pa at 25℃ |
refractive index | 1.4500 (estimate) |
storage temp. | Store below +30°C. |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Liquid |
pka | 4.50±1.00(Predicted) |
color | Clear colorless to slightly yellow |
Odor | Very faint woody-medicinal odor with a with Aluminum chloride. nut-like, hcrbaccous tone |
Water Solubility | PRACTICALLY INSOLUBLE |
BRN | 129768 |
InChIKey | VXIXUWQIVKSKSA-UHFFFAOYSA-N |
LogP | 1.6-2.31 at 21.2℃ |
CAS DataBase Reference | 1076-38-6(CAS DataBase Reference) |
EWG's Food Scores | 1 |
FDA UNII | X954ZLL2RD |
NIST Chemistry Reference | 4-Hydroxycoumarin(1076-38-6) |
EPA Substance Registry System | 2H-1-Benzopyran-2-one, 4-hydroxy- (1076-38-6) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302 | |||||||||
Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
Hazard Codes | Xn,Xi | |||||||||
Risk Statements | 22-36/37/38 | |||||||||
Safety Statements | 26-36 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | DJ3100000 | |||||||||
Hazard Note | Irritant | |||||||||
TSCA | Yes | |||||||||
HS Code | 29322980 | |||||||||
NFPA 704 |
|
4-Hydroxycoumarin price More Price(28)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | H23805 | 4-Hydroxycoumarin 98% | 1076-38-6 | 100g | $67.6 | 2024-03-01 | Buy |
Sigma-Aldrich | H23805 | 4-Hydroxycoumarin 98% | 1076-38-6 | 500g | $79.6 | 2024-03-01 | Buy |
Sigma-Aldrich | 40863 | 4-Hydroxycoumarin analytical standard | 1076-38-6 | 100MG | $69.1 | 2024-03-01 | Buy |
TCI Chemical | H0235 | 4-Hydroxycoumarin >98.0%(GC)(T) | 1076-38-6 | 25g | $37 | 2024-03-01 | Buy |
TCI Chemical | H0235 | 4-Hydroxycoumarin >98.0%(GC)(T) | 1076-38-6 | 250g | $266 | 2024-03-01 | Buy |
4-Hydroxycoumarin Chemical Properties,Uses,Production
Chemical Properties
Yellow powder or chunks or Slightly yellow needle-like crystals. freely soluble in ethanol, ether and hot water. brown in color with ferric chloride.
Uses
4-Hydroxycoumarin may be regarded as a phenylenetetronic acid , and like tetronic acid forms condensation products with aldehydes.
Synthesis of biscoumarin derivatives by the reaction of aldehydes and 4-hydroxycoumarin using ruthenium(III) chloride hydrate as a versatile homogeneous catalyst.
Uses
4-Hydroxycoumarin is involved in annulation reactions, due to the relatively high acidity of the C-H bond at the 3-position: a three-component reaction with isocyanides and dialkyl acetylene dicarboxylates affords annulated 4H-pyrans.
Uses
4-Hydroxycoumarin is a plant derived antioxidant, protecting against lipid peroxidation, as well as a potential inhibitor of HIV-1 Integrase. 4-Hydroxycoumarins are a very important class of biologically active drugs which are widely used as anticoagulants-Warfarin and Acenocoumarol.
Definition
ChEBI: 4-hydroxycoumarin is a hydroxycoumarin that is coumarin in which the hydrogen at position 4 is replaced by a hydroxy group. It is a conjugate acid of a 4-hydroxycoumarin(1-).
Synthesis Reference(s)
The Journal of Organic Chemistry, 25, p. 677, 1960 DOI: 10.1021/jo01074a630
Flammability and Explosibility
Not classified
Synthesis
4-Hydroxycoumarin is prepared by the reaction of o-hydroxyacetophenone and Diethyl carbonate. The steps are as follows:
General procedure: To a stirred mixture (1.15 mmol) and sodium hydride (138 mg, 5.75 mmol) in 5 ml dry toluene, a solution of the diethyl carbonate (1.15 mmol) in dry toluene was dropped. The mixture was reacted at 0°C for 30 min, then heated to reflux and reacted for another 4 h. The reaction mixture was quenched with water (20 mL) at ice bath and neutralized to pH 7 with 2 N HCl. The precipitate was filtered, washed with cold water and dried to get 6a-f. 1.2.1.1. 4-Hydroxy-2H-chromen-2-one (6a) White solidyield: 95; 1H NMR (600 MHz, DMSO-d6) δ 12.53 (s, 1H), 7.83 (d, J = 7.2 Hz, 1H), 7.65 (d, J = 7.8 Hz, 1H), 7.38-7.34 (m, 2H), 5.60 (s, 1H).
Purification Methods
Crystallise 4-hydroxycoumarin from water and dry it in a vacuum desiccator over pKEst Sicapent. [Beilstein 18/1 V 378.]
4-Hydroxycoumarin Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
1of2
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12450 | 58 |
Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 | daisy@crovellbio.com | China | 5828 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20294 | 58 |
Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3002 | 58 |
Hebei Shengyang Water Conservancy Engineering Co., Ltd. | +8615373025980 | clara@hbshengyang.com | China | 873 | 58 |
Hebei Ganmiao New material Technology Co., LTD | +86-17332992504 +86-17332992504 | sales8@hbganmiao.com | China | 300 | 58 |
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +8615383190639 | admin@86-ss.com | China | 1000 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 16914 | 58 |
View Lastest Price from 4-Hydroxycoumarin manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2024-08-24 | 4-Hydroxycoumarin
1076-38-6
|
US $100.00-75.00 / g | 1g | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
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2024-08-23 | 4-Hydroxycoumarin
1076-38-6
|
US $0.00 / KG | 1KG | 99% | 100mt/year | Jinan Finer Chemical Co., Ltd | |
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2024-08-22 | 4-Hydroxycoumarin
1076-38-6
|
US $0.00 / Kg/Drum | 1KG | 98%min HPLC | 10kgs | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- 4-Hydroxycoumarin
1076-38-6
- US $100.00-75.00 / g
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- 4-Hydroxycoumarin
1076-38-6
- US $0.00 / KG
- 99%
- Jinan Finer Chemical Co., Ltd
-
- 4-Hydroxycoumarin
1076-38-6
- US $0.00 / Kg/Drum
- 98%min HPLC
- WUHAN FORTUNA CHEMICAL CO., LTD