NECA
- CAS No.
- 35920-39-9
- Chemical Name:
- NECA
- Synonyms
- NECA;D-NECA;744-96;765-21;B-744-96;NECA USP/EP/BP;5'-ETHYLCARBOXAMIDOADENOSINE;5’-EthylcarboxamidoAdenosine;Adenosine-5'-ethylcarboxamide;5'-N-Ethylcarboxamideadenosine
- CBNumber:
- CB0763077
- Molecular Formula:
- C12H16N6O4
- Molecular Weight:
- 308.29
- MDL Number:
- MFCD00069195
- MOL File:
- 35920-39-9.mol
- MSDS File:
- SDS
Melting point | 229-231°C |
---|---|
Density | 1.87±0.1 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL Solutions may be stored for several days at 4°C. |
pka | 12.93±0.70(Predicted) |
form | powder |
color | white |
Stability | Hygroscopic |
InChIKey | JADDQZYHOWSFJD-FLNNQWSLSA-N |
CAS DataBase Reference | 35920-39-9 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS06 |
---|---|
Signal word | Danger |
Hazard statements | H300 |
Precautionary statements | P264-P270-P301+P310-P405-P501 |
Hazard Codes | T+ |
Risk Statements | 28 |
Safety Statements | 22-26-36-45 |
RIDADR | UN 2811 6.1/PG 2 |
WGK Germany | 3 |
RTECS | VJ2232000 |
HazardClass | 6.1(a) |
PackingGroup | I |
HS Code | 29349990 |
NECA price More Price(28)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | E2387 | 5′-(N-Ethylcarboxamido)adenosine powder | 35920-39-9 | 50mg | $223 | 2024-03-01 | Buy |
Sigma-Aldrich | 119140 | Adenosine Receptor Agonist, NECA | 35920-39-9 | 10mg | $69 | 2024-03-01 | Buy |
Alfa Aesar | J60405 | 5'-N-Ethylcarboxamidoadenosine | 35920-39-9 | 10mg | $83 | 2021-12-16 | Buy |
Alfa Aesar | J60405 | 5'-N-Ethylcarboxamidoadenosine | 35920-39-9 | 50mg | $351 | 2021-12-16 | Buy |
Cayman Chemical | 21420 | 5'-N-Ethylcarboxamidoadenosine ≥99% | 35920-39-9 | 5mg | $25 | 2021-12-16 | Buy |
NECA Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
5′-(N-Ethylcarboxamido)adenosine has been used:
- for the purification of human adenosine A2Areceptor (A2AR) in decylmaltoside (DM)
- to determine nonspecific binding of adenosine receptors
- to investigate adenosine 2B receptor (RA2B) mechanism of action by competition assay
Uses
Potent adenosine receptor agonist with some affinity at A1 and A2 receptors
Uses
A potent adenosine receptor agonist. Inhibits platelet aggregation and is centrally active in vivo
Definition
ChEBI: A derivative of adenosine in which the 5'-hydroxymethyl group is replaced by an N-ethylcarboxamido group.
General Description
A cell-permeable adenosine analog that acts a potent non-selective agonist of adenosine receptors (Ki = 14 nM, 20 nM, 2.4 μM and 6.2 nM for A1, A2A, A2B, A3, respectively). Increases intracellular cAMP production (EC50 = 3.1 μM in A2B expressing CHO cells). Shown to increase glucagon release in a dose-dependent manner and inhibit insulin release at low concentrations. Although at higher concentration some insulin release is observed. Also, displays a wide range adenosine-dependent effects, such as blocking platelet aggregation and inhibiting DNA synthesis. When administered at reperfusion, it is shown reduce infarction and block the formation of the mitochondrial permeability transition pore by activating p70S6 kinase.
Biological Activity
Potent adenosine receptor agonist (K i values are 14, 20 and 6.2 nM for human A 1 , A 2A and A 3 receptors respectively; EC 50 = 2.4 μ M for human A 2B ). Inhibits platelet aggregation and is centrally active in vivo .
Biochem/physiol Actions
Reversible: yes
storage
Store at +4°C
NECA Preparation Products And Raw materials
Raw materials
Preparation Products
NECA Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29896 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
TopScience Biochemical | 00852-68527855 | info@itopbiochem.com | China Hong Kong | 902 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 24330 | 58 |
NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | sales@newcanbio.com | China | 9980 | 58 |
Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |