HWL-088
- CAS No.
- 2378617-96-8
- Chemical Name:
- HWL-088
- Synonyms
- HWL-088;HWL088,HWL 088;2-(2-fluoro-4-((2'-methyl-[1,1'-biphenyl]-3-yl)methoxy)phenoxy)acetic acid;Acetic acid, 2-[2-fluoro-4-[(2'-methyl[1,1'-biphenyl]-3-yl)methoxy]phenoxy]-
- CBNumber:
- CB08054432
- Molecular Formula:
- C22H19FO4
- Molecular Weight:
- 366.38
- MDL Number:
- MFCD32263430
- MOL File:
- 2378617-96-8.mol
HWL-088 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0105155 | HWL-088 98.80% | 2378617-96-8 | 5mg | $350 | 2021-12-16 | Buy |
| ChemScene | CS-0105155 | HWL-088 98.80% | 2378617-96-8 | 10mg | $580 | 2021-12-16 | Buy |
| ChemScene | CS-0105155 | HWL-088 98.80% | 2378617-96-8 | 25mg | $1100 | 2021-12-16 | Buy |
| ChemScene | CS-0105155 | HWL-088 98.80% | 2378617-96-8 | 50mg | $1700 | 2021-12-16 | Buy |
| ChemScene | CS-0105155 | HWL-088 98.80% | 2378617-96-8 | 100mg | $2500 | 2021-12-16 | Buy |
HWL-088 Chemical Properties,Uses,Production
Biological Activity
HWL-088 is a highly potent and orally active free fatty acid receptor 1 (FFA1/GPR40) agonist (EC50 of 18.9 nM) with moderate PPARδ activity (EC50 of 570.9 nM) . HWL-088 improves glucose and lipid metabolism, and has anti-diabetic effects[1][2]. HWL-088 (0.3 μM and 3μM) significantly increases insulin secretion fromMIN6 cells at 25 mM but not at 2 mM glucose. HWL-088 reveales a dose-dependent insulinotropic effect in the presence of 25-mM glucose[2]. HWL-088 (40 mg/kg; oral gavage; daily; for 30 days; ob/ob mice) treatment improves β-cell function by up-regulation of pancreas duodenum homeobox-1, reduces fat accumulation in adipose tissue and alleviated fatty liver in ob/ob mice. The effect of HWL-088 involves a reduction in hepatic lipogenesis and oxidative stress, increased lipoprotein lipolysis, glucose uptake, mitochondrial function and fatty acid β-oxidation[2].
References
[1]. Li Z, et al. Discovery of HWL-088: A highly potent FFA1/GPR40 agonist bearing a phenoxyacetic acid scaffold. Bioorg Chem. 2019 Nov;92:103209. [2]. Yueming Chen, et al. HWL-088, a new potent free fatty acid receptor 1 (FFAR1) agonist, improves glucolipid metabolism and acts additively with metformin in ob/ob diabetic mice. Br J Pharmacol. 2020 May;177(10):2286-2302.
HWL-088 Preparation Products And Raw materials
Raw materials
Preparation Products
HWL-088 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Shanghai Beckham Medical Technology Co., Ltd | 021-13816613772 13816613772 | huahero21@sina.com | China | 373 | 55 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 14768611851 | 486064515@qq.com | China | 1706 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4399 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9155 | 58 |