Bevantolol
- CAS No.
- 59170-23-9
- Chemical Name:
- Bevantolol
- Synonyms
- Bevantolol;Bevanolol.;NSC 132348;DL-Bevantolol;Bevantolol USP/EP/BP;1-((3,4-DiMethoxyphenethyl)aMino)-3-(M-tolyloxy)propan-2-ol;1-[(3,4-Dimethoxyphenethyl)amino]-3-(m-tolyloxy)-2-propanol;1-(3,4-Dimethoxyphenethylamino)-3-(3-methylphenoxy)-2-propanol;2-Propanol, 1-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-3-(3-methylphenoxy)-
- CBNumber:
- CB0875462
- Molecular Formula:
- C20H27NO4
- Molecular Weight:
- 345.43
- MDL Number:
- MOL File:
- 59170-23-9.mol
| storage temp. | 2-8°C |
|---|---|
| CAS DataBase Reference | 59170-23-9 |
| FDA UNII | 34ZXW6ZV21 |
| ATC code | C07AB06 |
Bevantolol price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | API0009101 | BEVANTOLOL 95.00% | 59170-23-9 | 5MG | $503.95 | 2021-12-16 | Buy |
| Crysdot | CD31001372 | Bevantolol 95+% | 59170-23-9 | 1g | $947 | 2021-12-16 | Buy |
| AvaChem | 2822B | Bevantolol | 59170-23-9 | 10g | $1190 | 2021-12-16 | Buy |
| AvaChem | 2822B | Bevantolol | 59170-23-9 | 10mg | $39 | 2021-12-16 | Buy |
| AvaChem | 2822B | Bevantolol | 59170-23-9 | 100mg | $89 | 2021-12-16 | Buy |
Bevantolol Chemical Properties,Uses,Production
Originator
Bevantolol hydrochloride,Parke, Davis (Pfizer)
Definition
ChEBI: Bevantolol is a propanolamine that is 3-aminopropane-1,2-diol in which the hydrogen of the primary hydroxy group is substituted by 3-methylphenyl and one of the hydrogens attached to the nitrogen is substituted by 2-(3,4-dimethoxyphenyl)ethyl. A beta1 adrenoceptor antagonist, it has been shown to be as effective as other beta-blockers for the treatment of angina pectoris and hypertension. It has a role as a beta-adrenergic antagonist, a calcium channel blocker, an antihypertensive agent and an anti-arrhythmia drug.
Manufacturing Process
To a solution of 50 g (1.25 mol) of NaOH in 1200 ml H2O was added 108 g (1
mol) of m-cresol freshly distilled and at 15°C in one lot 117ml (1.5 mol) of
epichlorohydrin. The emulsion was stirred at room temperature for 16 hours in
a creased flask. The product was taken up in 1000 ml of toluene and washed
with 500 ml water. Distillation yielded 135.7 g=82% of 3-(m-tolyloxy)-1,2-
epoxypropane, b.p. 61°C at 0.05 mm.
Preparation of bevantolol hydrochloride:
To a suitable reactor under a nitrogen blanket is added 13.7 kg of β-(3,4-
dimethoxyphenyl)ethylamine. The amine is cooled to 5°C and 12.5 kg of 3-
(m-tolyloxy)-1,2-epoxypropane is added maintaining the temperature between
5-10°C. After 10 hours, the mixture is seeded with bevantolol free base;
seeding is repeated approximately every 2 hours until it is evident that
crystallization has started. After stirring for 48 hours at 10°C, 26 L of hexane
is added. The temperature is raised to 25°C and stirring is continued for 48
hours. The slurry is filtered and the collected solid is dried under vacuum. The
product is dissolved in 60 L of isopropyl alcohol and the solution is filtered.
The reactor and filter are rinsed with 186 L of isopropyl alcohol and 2.7 kg of
anhydrous hydrogen chloride is added to the combined filtrate. The batch is
heated to reflux for 2 hours. The temperature is adjusted to 65°C and the
solution is seeded with bevantolol hydrochloride crystals. The mixture is held
at this temperature with stirring until a heavy sand-like slurry is present. The
mixture is allowed to cool to ambient temperature without stirring or artificial
cooling. It is then cooled to 20°C. The slurry is centrifuged and the product
rinsed with isopropyl alcohol until the filtrate is colorless. After being vacuum
dried at 50-55°C the product is milled if necessary; yield of bevantolol
hydrochloride 22.7 kg (78.6%); melting point 137-138°C.
Therapeutic Function
Antiarrhythmic, Beta-adrenergic blocker
Enzyme inhibitor
This antihypertensive agent (FW = 345.43 g/mol; CAS 59170-23-9), also known by the code name NC-1400 and systematically as (RS)-[2-(3,4- dimethoxyphenyl)ethyl]-[2-hydroxy-3-(3-methylphenoxy)propyl]amine, is a dual-action b-blocker and calcium ion channel blocker. Bevantolol is a selective b1-adrenoceptor blocker with some blocking activity of a1- adrenoceptors.
Bevantolol Preparation Products And Raw materials
Bevantolol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22787 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19885 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2123 | 70 |
| Aikon International Limited | 025-66113011 18112977050 | cb6@aikonchem.com | China | 15494 | 58 |
| Mianyang Vandino Pharmaceutical Technology Co., Ltd. | 0816-1568120-1579 15681201579 | 1755695756@qq.com | China | 309 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24644 | 58 |
View Lastest Price from Bevantolol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-28 | Bevantolol
59170-23-9
|
US $1980.00-2500.00 / mg | 10g | TargetMol Chemicals Inc. | |||
 |
2021-08-13 | Bevantolol USP/EP/BP
59170-23-9
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited |
-
- Bevantolol
59170-23-9
- US $1980.00-2500.00 / mg
- TargetMol Chemicals Inc.
-
- Bevantolol USP/EP/BP
59170-23-9
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited