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UMB298

UMB298 Structure
UMB298 structure
CAS No.
2266569-73-5
Chemical Name:
UMB298
Synonyms
UMB298;UMB-298,UMB298,inhibit,MOLM13,Inhibitor,bromodomain,UMB 298,selective,potent,Epigenetic Reader Domain,CBP30;2-[2-(3-chloro-4-methoxyphenyl)ethyl]-N-cyclohexyl-7-(3,5-dimethyl-1,2-oxazol-4-yl)imidazo[1,2-a]pyridin-3-amine;Imidazo[1,2-a]pyridin-3-amine, 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-N-cyclohexyl-7-(3,5-dimethyl-4-isoxazolyl)-
CBNumber:
CB09401947
Molecular Formula:
C27H31ClN4O2
Molecular Weight:
479.01
MDL Number:
MFCD34474161
MOL File:
2266569-73-5.mol
Last updated:2024-11-07 21:39:59
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UMB298 Properties

Density 1.29±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 25 mg/mL (52.19 mM; Need ultrasonic)
pka 7.87±0.50(Predicted)

UMB298 Chemical Properties,Uses,Production

Biological Activity

UMB298 is a potent and selective CBP/P300 bromodomain inhibitor[1]. UMB298 (0.01~10 μM; 50 days; MOLM13 and MM cells) inhibits cells growth[1].UMB298 (1~10 μM; 2 hours; MOLM13 cells) reduces the H3K27ac level similar to CBP30 and causes MYC depletion as a signature of CBP inhibition in acute myeloid leukemia[1].UMB298 (3 μM; 2hours; MOLM13 cells) down-regulates MYC expression[1].

References

[1]. Muthengi A, et al. Development of Dimethylisoxazole-Attached Imidazo[1,2-a]pyridines as Potent and Selective CBP/P300 Inhibitors. J Med Chem. 2021;64(9):5787-5801.

UMB298 Preparation Products And Raw materials

Raw materials

Preparation Products

UMB298 Suppliers

Global( 13)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32072 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38466 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4456 55
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8012 62
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 Sales@ATKchemical.com China 7045 58
Fujian boshi pharmaceutical technology co. LTD 0595-22008920; 18120708884 393612455@qq.com China 255 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24648 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 4870 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11974 58
https://hanhongsci.com/ 021-54306202 18917919676 info@hanhongsci.com China 29977 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
Shanghai Lollane Biological Technology Co.,Ltd. 55
ShangHai Biochempartner Co.,Ltd 62
Shanghai Chaolan Chemical Technology Center 58
Fujian boshi pharmaceutical technology co. LTD 58
TargetMol Chemicals Inc. 58
Nantong QuanYi Biotechnology Co., Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
https://hanhongsci.com/ 58

View Lastest Price from UMB298 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
UMB298 pictures 2024-11-07 UMB298
2266569-73-5
 US $58.00-230.00 / mg 99.76% 10g TargetMol Chemicals Inc.
  • UMB298 pictures
  • UMB298
    2266569-73-5
  • US $58.00-230.00 / mg
  • 99.76%
  • TargetMol Chemicals Inc.
UMB298 UMB-298,UMB298,inhibit,MOLM13,Inhibitor,bromodomain,UMB 298,selective,potent,Epigenetic Reader Domain,CBP30 Imidazo[1,2-a]pyridin-3-amine, 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-N-cyclohexyl-7-(3,5-dimethyl-4-isoxazolyl)- 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-N-cyclohexyl-7-(3,5-dimethyl-1,2-oxazol-4-yl)imidazo[1,2-a]pyridin-3-amine 2266569-73-5