1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane
- CAS No.
- 69304-37-6
- Chemical Name:
- 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane
- Synonyms
- TIPSCL;1,1,3,3-TETRAISOPROPYL-1,3-DICHLORODISILOXANE;TIPDSICL2;1,3-DICHLOROTETRAISOPROPYLDISILOXANE;DK365;DK870;DKSI013;DKFELEX0228;JACS-69304-37-6;2,6-DiMethyl-3,5-dichloro
- CBNumber:
- CB1100268
- Molecular Formula:
- C12H28Cl2OSi2
- Molecular Weight:
- 315.43
- MDL Number:
- MFCD00009655
- MOL File:
- 69304-37-6.mol
- MSDS File:
- SDS
| Boiling point | 70 °C0.5 mm Hg(lit.) |
|---|---|
| Density | 0.986 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Miscible with dimethylformamide, hexane, ethyl acetate, chloroform and dichloromethane. |
| form | Oil |
| color | Colourless |
| Specific Gravity | 0.986 |
| Hydrolytic Sensitivity | 8: reacts rapidly with moisture, water, protic solvents |
| Sensitive | Moisture Sensitive |
| BRN | 1934216 |
| InChI | InChI=1S/C12H28Cl2OSi2/c1-9(2)16(13,10(3)4)15-17(14,11(5)6)12(7)8/h9-12H,1-8H3 |
| InChIKey | DDYAZDRFUVZBMM-UHFFFAOYSA-N |
| SMILES | [Si](Cl)(C(C)C)(C(C)C)O[Si](Cl)(C(C)C)C(C)C |
| CAS DataBase Reference | 69304-37-6(CAS DataBase Reference) |
| UNSPSC Code | 12352001 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H290-H314 | |||||||||
| Precautionary statements | P280-P303+P361+P353-P305+P351+P338+P310 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34 | |||||||||
| Safety Statements | 26-27-28-36/37/39-45 | |||||||||
| RIDADR | UN 3265 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| Hazard Note | Corrosive | |||||||||
| TSCA | No | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29319090 | |||||||||
| NFPA 704 |
|
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 337005 | 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane 97% | 69304-37-6 | 1g | $27.06 | 2024-03-01 | Buy |
| Sigma-Aldrich | 337005 | 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane 97% | 69304-37-6 | 5g | $133 | 2024-03-01 | Buy |
| TCI Chemical | D1608 | 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane [Hydroxyl Protecting Agent] >97.0%(GC) | 69304-37-6 | 5g | $116 | 2024-03-01 | Buy |
| TCI Chemical | D1608 | 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane [Hydroxyl Protecting Agent] >97.0%(GC) | 69304-37-6 | 25g | $348 | 2024-03-01 | Buy |
| Alfa Aesar | L11171 | 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane, 97% | 69304-37-6 | 5g | $202 | 2024-03-01 | Buy |
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane Chemical Properties,Uses,Production
Chemical Properties
Colorless liquid
Physical properties
bp 70°C/0.5 mmHg; d 0.986 g cm?3.
Uses
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane can be used as simultaneous protection of the 3'- and 5'-hydroxyl functions of
furanose nucleosides;protecting group for carbohydrates;3,4
protecting group reagent for open-chain polyhydroxy compounds;
preparation of cyclic bridged peptides.
The reagent
design was based upon the fact that triisopropylsilyl chloride
reacts 1000 times faster with primary alcohols than secondary
alcohols. Thus in the case of 3',5'-dihydroxy nucleosides the
reagent initially silylates at the 5'-position. This is then followed
by intramolecular reaction with the secondary alcohol at the
3'-position to give the doubly protected derivative (eq 1).
Uses
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane is used in the analysis of Watson-Crick and Hoogstein base pairing in nucleotides. Also used in the formation of ribavirin chemical delivery systems.
Uses
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane is a silylating reagent used for simultaneous protection of 3'- and 5'-hydroxy functions of ribonucleosides. It is used in the analysis of Watson-Crick and Hoogstein base pairing in nucleotides. It is also employed in the formation of ribavirin chemical delivery systems. Further, it serves as a protecting group reagent for open-chain polyhydroxy compounds. In addition to this, it is involved in the preparation of cyclic bridged peptides.
Preparation
can be prepared starting from trichlorosilane by treatment with i-PrMgCl, H2O, and acetyl chloride. Alternatively, it can be prepared by the reaction of 1,1,3,3- tetraisopropyldisiloxane with CCl4 in the presence of catalytic PdCl2.This method is also suitable for its in situ preparation.
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-+86-371-66670886 | info@dakenam.com | China | 19805 | 58 |
| Shanghai Zhuangming Biopharma Co., Ltd. | +86-19189228086 +86-18858568638 | sales@zmsilane.com | China | 641 | 58 |
| Hebei Junhua Import and Export Co., LTD | +86-18503288844 +86-18503288844 | junhua1@hb-junhua.com | China | 978 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29730 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21628 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Zjartschem | +86-571 87238903 | jocelynpan@zjarts.com | CHINA | 988 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29858 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
View Lastest Price from 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-25 | 1,3-dichloro-1,1,3,3-tetraisopropyldisiloxane | US $0.00 / kg | 1kg | 97% | 1000 | Hebei Junhua Import and Export Co., LTD | |
 |
2025-04-04 | 1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE
69304-37-6
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2024-08-07 | 1,3-Dichloro-1,1,3,3-Tetraisopropyldisiloxan
69304-37-6
|
US $0.00-0.00 / KGS | 5KGS | 97+% | 10ton/year | Yunbio Tech Co.,Ltd. |
-
- 1,3-dichloro-1,1,3,3-tetraisopropyldisiloxane
- US $0.00 / kg
- 97%
- Hebei Junhua Import and Export Co., LTD
-
- 1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE
69304-37-6
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 1,3-Dichloro-1,1,3,3-Tetraisopropyldisiloxan
69304-37-6
- US $0.00-0.00 / KGS
- 97+%
- Yunbio Tech Co.,Ltd.
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