Alatrofloxacin
- CAS No.
- 146961-76-4
- Chemical Name:
- Alatrofloxacin
- Synonyms
- D07562;Alatrofloxacin;Alatrofloxacin (inn);UUZPPAMZDFLUHD-VUJLHGSVSA-N;L-Alaninamide, L-alanyl-N-[(1α,5α,6α)-3-[6-carboxy-8-(2,4-difluorophenyl)-3-fluoro-5,8-dihydro-5-oxo-1,8-naphthyridin-2-yl]-3-azabicyclo[3.1.0]hex-6-yl]-;L-Alanyl-N-[(1alpha,5alpha,6alpha)-3-[6-Carboxy-8-(2,4-Difluorophenyl)-3-Fluoro-5,8-Dihydro-5-Oxo-1,8-Naphthyridin-2-Yl]-3-Azabicyclo[3.1.0]Hex-6-Yl]-L-Alaninamide
- CBNumber:
- CB11102904
- Molecular Formula:
- C26H25F3N6O5
- Molecular Weight:
- 558.51
- MDL Number:
- MFCD02183849
- MOL File:
- 146961-76-4.mol
| Boiling point | 863.2±65.0 °C(Predicted) |
|---|---|
| Density | 1.57±0.1 g/cm3(Predicted) |
| pka | 5.80±0.70(Predicted) |
| FDA UNII | 7QVV6I50DT |
Alatrofloxacin price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | API0015025 | 7-[(1R,5S)-6-([(2S)-1-([(2S)-2-AMINOPROPANOYL]AMINO)-1-OXOPROPAN-2-YL]AMINO)-3-AZABICYCLO[3.1.0]HEXAN-3-YL]-1-(2,4-DIFLUOROPHENYL)-6-FLUORO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC?ACID 95.00% | 146961-76-4 | 5MG | $502.43 | 2021-12-16 | Buy |
| Product number | Packaging | Price | Buy |
|---|---|---|---|
| API0015025 | 5MG | $502.43 | Buy |
Alatrofloxacin Chemical Properties,Uses,Production
Uses
Alatrofloxacin, the parenteral proagent of Trovafloxacin, is a fluoronaphthyridone which contains an L-alanyl-L-alanyl salt. Alatrofloxacin functions similar to other fluoroquinolone antibiotics in that it not only has antibiotic activity to kill invading organisms by interfering with DNA synthesis, it possesses immunosuppressive activity[1].
Definition
ChEBI: Alatrofloxacin is a peptide.
Enzyme inhibitor
This fourth-generation fluoroquinolone-class antibiotic (FW = 558.51 g/mol; CAS 146961-76-4; quickly hydrolyzes to form trovafloxacin), also named 7-[(1R,5S)-6-{[(2S)-1-{[(2S)-2-aminopropanoyl]amino}-1-oxopropan- 2-yl]amino}-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6- fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid, is a systemic antibacterial that targets Type II DNA topoisomerases (gyrases) required for bacterial replication and transcription. This fluoroquinolone shows an extensive in vitro antibiotic spectrum, with high activity against Grampositive coccus, anaerobic and atypical pneumonia-producing bacteria. (For the prototypical member of this antibiotic class, See Ciprofloxacin) Intravenous alatrofloxacin, followed by oral trovafloxacin (TVX), is safe and well tolerated. Alatrofloxacin also lacks the phototoxicity, cardiovascular toxicity, and hemolytic anemia associated with earlier fluoroquinolones. Given its metabolism to trovafloxacin, it should be noted that the latter significantly increases the formation of nitrotyrosine in mice that are heterozygous for mitochondrial superoxide dismutase-2. Using the NO-selective probe DAF-2, TVX also increases the production of mitochondrial NO in immortalized human hepatocytes. Similarly, mitochondrial Ca2+ is increased by TVX, suggesting calcium ion-dependent activation of mitochondrial NOS activity. The relationship between these observations and trovafloxacin-induced leukopenia remains to be explored.
IC 50
Quinolone
References
[1] Hall IH, et al. Effects of alatrofloxacin, the parental prodrug of trovafloxacin, on phagocytic, anti-inflammatory and immunomodulation events of human THP-1 monocytes. Biomed Pharmacother. 2003;57(8):359-365. DOI:10.1016/s0753-3322(03)00054-4
Alatrofloxacin Preparation Products And Raw materials
Raw materials
Preparation Products
Alatrofloxacin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29808 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32222 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22855 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +8619945049750 | info@finetechnology-ind.com | China | 9642 | 58 |
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19893 | 58 |
| Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9650 | 58 |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2317 | 55 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19784 | 58 |
View Lastest Price from Alatrofloxacin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-24 | Alatrofloxacin
146961-76-4
|
US $1820.00-3100.00 / mg | 10g | TargetMol Chemicals Inc. | |||
 |
2021-07-22 | Alatrofloxacin USP/EP/BP
146961-76-4
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2019-12-23 | Alatrofloxacin
146961-76-4
|
US $1.00 / KG | 1KG | 98% HPLC | 10t | Career Henan Chemical Co |
-
- Alatrofloxacin
146961-76-4
- US $1820.00-3100.00 / mg
- TargetMol Chemicals Inc.
-
- Alatrofloxacin USP/EP/BP
146961-76-4
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Alatrofloxacin
146961-76-4
- US $1.00 / KG
- 98% HPLC
- Career Henan Chemical Co