Zatebradine
- CAS No.
- 85175-67-3
- Chemical Name:
- Zatebradine
- Synonyms
- Zatebradine;UL-FS-49 free base;UL-FS-49CL free base;Zatebradine (UL-FS-49;3-(3-((3,4-Dimethoxyphenethyl)(methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one;2H-3-Benzazepin-2-one, 3-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-
- CBNumber:
- CB11117164
- Molecular Formula:
- C26H36N2O5
- Molecular Weight:
- 456.58
- MDL Number:
- MFCD06798356
- MOL File:
- 85175-67-3.mol
| Boiling point | 612.5±55.0 °C(Predicted) |
|---|---|
| Density | 1.115±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO : ≥ 50 mg/mL (109.51 mM) |
| pka | 8.99±0.50(Predicted) |
| form | Oil |
| color | Light brown to brown |
| FDA UNII | TV27RY5876 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Zatebradine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-3620 | Zatebradine 99.0% | 85175-67-3 | 5mg | $85 | 2021-12-16 | Buy |
| ChemScene | CS-3620 | Zatebradine 99.0% | 85175-67-3 | 10mg | $135 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | BRS0000235 | ZATEBRADINE 95.00% | 85175-67-3 | 5MG | $501.93 | 2021-12-16 | Buy |
| ChemScene | CS-3620 | Zatebradine 99.0% | 85175-67-3 | 50mg | $588 | 2021-12-16 | Buy |
| DC Chemicals | DC9461 | Zatebradine >98% | 85175-67-3 | 250mg | $1000 | 2021-12-16 | Buy |
Zatebradine Chemical Properties,Uses,Production
Originator
ZATEBRADINE HYDROCHLORIDE,Boenhringer Ingelheim
Definition
ChEBI: 3-[3-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one is a benzazepine.
Manufacturing Process
A suspension of 1-[7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on-3-yl]-3-
(N-benzylmethylamino)propane and 10% palladium-on-charcoal in glacial
acetic acid was hydrogenated at 50°C and at a hydrogen pressure of 5 bar.
After the catalyst had been filtered off, the solvent was evaporated in vacuum,
and the residue was taken up in methylene chloride. After the solution had
been extracted with an aqueous sodium bicarbonate solution and washed with
water, it was dried over magnesium sulfate, evaporated and purified over
silica gel with methylene chloride and then with increasing amounts of
methanol (up to 10%). The N-[3-(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-
benzazepin-2-one-3-yl)propyl]methylamine hydrochloride. Yield: 87% of
theory. Melting point: 110°C (dec.).
1.26 g (20 mmols) of sodium cyanoborohydride were added to a solution of
3.29 g (10 mmols) of N-[3-(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-
benzazepin-2-one-3-yl)propyl]methylamine hydrochloride and 1.8 g (10
mmol) of 2-(3,4-dimethoxyphenyl)acetaldehyde in 40 ml of ethanol, while
maintaining a pH of 6-7 by the addition of 2 N hydrochloric acid, and stirring
was continued for 48 h at room temperature. After evaporating the solution in
vacuum, the residue was taken up in dilute hydrochloric acid and extracted
twice with ether. Subsequently, the aqueous phase was made alkaline and
extracted three times with methylene chloride, and the organic phase was
evaporated and purified on silica gel. The 1-[7,8-dimethoxy-1,3,4,5-
tetrahydro-2H-3-benzazepin-2-on-3-yl]-3-[N-methyl-N-(2-{3,4-
dimethoxyphenyl}ethyl)amino]propane was obtained.
Therapeutic Function
Bradycardic
Zatebradine Preparation Products And Raw materials
Zatebradine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32250 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9304 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38653 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| ShangHai KenEn Chemical Technology Co., Ltd. | 13120367189 | mychess007@163.com | China | 1994 | 55 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
| Guangzhou QiYun Biotechnology Co., Ltd. | 020-61288194 61288195 | 505721671@qq.com | China | 3866 | 58 |
View Lastest Price from Zatebradine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-24 | Zatebradine
85175-67-3
|
US $88.00 / mg | 10g | TargetMol Chemicals Inc. | |||
 |
2021-07-13 | Zatebradine
85175-67-3
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-10 | Zatebradine
85175-67-3
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Zatebradine
85175-67-3
- US $88.00 / mg
- TargetMol Chemicals Inc.
-
- Zatebradine
85175-67-3
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Zatebradine
85175-67-3
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd