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ChemicalBook >> CAS DataBase List >>L-Valine, N-acetyl-L-alanyl-, methyl ester (9CI)

L-Valine, N-acetyl-L-alanyl-, methyl ester (9CI)

L-Valine, N-acetyl-L-alanyl-, methyl ester (9CI) Structure
L-Valine, N-acetyl-L-alanyl-, methyl ester (9CI) structure
CAS No.
99141-91-0
Chemical Name:
L-Valine, N-acetyl-L-alanyl-, methyl ester (9CI)
Synonyms
Ac-Ala-Val-OMe;ZZL-7, 10 mM in DMSO;ZZL-7 / Ac-Ala-Val-OMe;L-Valine, N-acetyl-L-alanyl-, methyl ester (9CI);(S)-Methyl 2-((S)-2-acetamidopropanamido)-3-methylbutanoate
CBNumber:
CB111435386
Molecular Formula:
C11H20N2O4
Molecular Weight:
244.29
MDL Number:
MOL File:
99141-91-0.mol
Last updated:2025-04-18 09:51:34
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L-Valine, N-acetyl-L-alanyl-, methyl ester (9CI) Properties

Melting point 105 °C
Boiling point 442.1±25.0 °C(Predicted)
Density 1.078±0.06 g/cm3(Predicted)
storage temp. -10 to -25°C
solubility Soluble to 100 mM in ethanol and to 100 mM in DMSO
pka 13.30±0.46(Predicted)
form Oil
color White to off-white
UNSPSC Code 12352200
NACRES NA.77

L-Valine, N-acetyl-L-alanyl-, methyl ester (9CI) Chemical Properties,Uses,Production

Uses

ZZL-7 is a fast-onset antidepressant agent. ZZL-7 works by disrupting the interaction between the serotonin transporter (SERT) and neuronal nitric oxide synthase (nNOS) in the dorsal raphe nucleus (DRN). ZZL-7 can cross the blood-brain barrier readily. ZZL-7 can be used for the research of major depressive disorder (MDD)[1].

Biological Activity

ZZL-7 is a fast-acting antidepressant that enhances 5-HT (serotonin) signaling in forebrain circuits. ZZL-7 disrupts the interaction between the 5-HT transporter (SERT) and neuronal nitric oxide synthase (nNOS) in the dorsal raphe nucleus (DRN), which reduces extracellular 5-HT concentration and down-regulates 5-HT1A receptor auto-activity in the DRN. This reduced auto-inhibition enables increase in firing frequency of serotonergic neurons in the DRN and increases in 5-HT release in the medial hippocampus. ZZL-7 can readily cross the blood-brain barrier.

in vivo

ZZL-7 (10 mg/kg, intraperitoneally) causes significantly increases firing frequency of serotonergic neurons 2 hours after treatment in vivo electrophysiology in SERT-Cre mice. In wild-type mice, ZZL-7 reduces immobility time[1].
Intragastric administration of ZZL-7 (10, 20, and 40 mg/kg; once) produces antidepressant-like behaviors dose dependently 2 hours after treatment[1].
ZZL-7 (10 mg/kg; intraperitoneal administration) reverses chronic unpredictable mild stress (CMS)-induced depressions behaviors 2 hours after treatment[1].

Animal Model:SERT-Cre mice[1]
Dosage:10 mg/kg
Administration:i.p.; once
Result:Significantly increased firing frequency of serotonergic neurons 2 hours after treatment in vivo electrophysiology in SERT-Cre mice.

storage

Store at -20°C

References

[1] Nan Sun, et al. Design of fast-onset antidepressant by dissociating SERT from nNOS in the DRN. Science. 2022 Oct 28;378(6618):390-398. DOI:10.1126/science.abo3566

L-Valine, N-acetyl-L-alanyl-, methyl ester (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

L-Valine, N-acetyl-L-alanyl-, methyl ester (9CI) Suppliers

Global( 15)Suppliers
Supplier Tel Email Country ProdList Advantage
Wuhan senwayer century chemical Co.,Ltd 		+undefined-27-86652399 +undefined13627115097 market02@senwayer.com China 923 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 6187 55
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136 Sales@ATKchemical.com China 9328 58
Hangzhou Peptidego Biotech Co.,Ltd. 0571-87213919 Eric@peptidego.com China 7062 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 62072 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24642 58
Hangzhou Sinoda Pharmaceutical Technology Co. LTD 0571-87213919 17306812703 3007955328@qq.com China 6627 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9835 58
Supplier Advantage
Wuhan senwayer century chemical Co.,Ltd 		58
TargetMol Chemicals Inc. 		58
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Shanghai Chaolan Chemical Technology Center 58
Hangzhou Peptidego Biotech Co.,Ltd. 58
Bide Pharmatech Ltd. 58
TargetMol Chemicals Inc. 58
Hangzhou Sinoda Pharmaceutical Technology Co. LTD 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
RD International Technology Co., Limited 58

View Lastest Price from L-Valine, N-acetyl-L-alanyl-, methyl ester (9CI) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ZZL-7 pictures 2024-11-16 ZZL-7
99141-91-0
 US $47.00-163.00 / mg 99.79% 10g TargetMol Chemicals Inc.
ZZL-7 / Ac-Ala-Val-OMe pictures 2024-09-25 ZZL-7 / Ac-Ala-Val-OMe
99141-91-0
 US $0.00 / g 1g 99% min 20 tons Wuhan Senwayer Century Chemical Co.,Ltd
  • ZZL-7 pictures
  • ZZL-7
    99141-91-0
  • US $47.00-163.00 / mg
  • 99.79%
  • TargetMol Chemicals Inc.

L-Valine, N-acetyl-L-alanyl-, methyl ester (9CI) Spectrum

L-Valine, N-acetyl-L-alanyl-, methyl ester (9CI)(99141-91-0)1HNMR
L-Valine, N-acetyl-L-alanyl-, methyl ester (9CI) Ac-Ala-Val-OMe ZZL-7 / Ac-Ala-Val-OMe (S)-Methyl 2-((S)-2-acetamidopropanamido)-3-methylbutanoate ZZL-7, 10 mM in DMSO 99141-91-0