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Febrifugine

Febrifugine structure

CAS No.: 24159-07-7

Chemical Name:: Febrifugine

Synonyms: febrifugin;ferifugine;β-dichroine;Febrifugine;Radix Dichroae;(+)-Febrifugine;BETA-Febrifugine;Febrifugine USP/EP/BP;Febrifugine，Isofebrifugine;Febrifugine (6-Desoxyswietenine)

CBNumber:: CB11178705

Molecular Formula:: C16H19N3O3

Molecular Weight:: 301.34

MDL Number:

MOL File:: 24159-07-7.mol

Last updated:2024-07-02 08:54:59

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Febrifugine Properties

Melting point	139-140°; mp 154-156°
alpha	D25 +6° (c = 0.5 in chloroform); D25 +28° (c = 0.5 in ethanol)
Density	1.39
storage temp.	2-8°C
solubility	DMF: 1.5 mg/ml; DMSO: 3.0 mg/ml; Ethanol: 0.1 mg/ml; PBS (pH 7.2): 2.5 mg/ml
form	A crystalline solid
Boiling point	508.2±60.0 °C(Predicted)
pka	14.61±0.40(Predicted)
color	White to off-white
CAS DataBase Reference	24159-07-7
FDA UNII	89UWD0FH2I

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P330-P501

Toxicity

LD50 orally in white mice: 2.5-3.0 mg/kg (Koepfli, 1949)

NFPA 704

	0
2		0

Febrifugine price More Price(14)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	14246	Febrifugine	24159-07-7	1mg	$37	2024-03-01	Buy
Cayman Chemical	14246	Febrifugine	24159-07-7	5mg	$169	2024-03-01	Buy
Usbiological	300268	Febrifugine	24159-07-7	20mg	$665	2021-12-16	Buy
American Custom Chemicals Corporation	CCH0003303	3-[3-[3(S)-HYDROXYPIPERIDIN-2(R)-YL]-2-OXOPROPYL]-3,4-DIHYDROQUINAZOLIN-4-ONE 95.00%	24159-07-7	1G	$3854.55	2021-12-16	Buy
ChemScene	CS-0022587	Febrifugine	24159-07-7	5mg	$336	2021-12-16	Buy

Product number	Packaging	Price	Buy
14246	1mg	$37	Buy
14246	5mg	$169	Buy
300268	20mg	$665	Buy
CCH0003303	1G	$3854.55	Buy
CS-0022587	5mg	$336	Buy

Febrifugine Chemical Properties,Uses,Production

Description

Febrifugine is a quinazolinone alkaloid originally isolated from D. febrifuga that has antimalarial activity. It reduces parasitemia and decreases mortality in mice infected with the P. berghei strain NK65 when administered at a dose of 1 mg/kg per day beginning prior to or on the day of infection.

Uses

Febrifugine is a quinazoline alkaloid with significant antimalarial and anticancerous efficacy. Febrifugine is an NRF2 inhibitor, that works with halofuginone for the treatment of chemo- and radio-resistant forms of cancer. Febrifugine analogs also functions as antimalarial, anticancer agents and in the prevention of chicken coccidiosis.

Febrifugine Preparation Products And Raw materials

Raw materials

Preparation Products

Febrifugine Suppliers

Global( 116)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	scglp@glp-china.com	CHINA	1824	58
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3424	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Shaanxi Pioneer Biotech Co., Ltd .	+8613259417953	sales@pioneerbiotech.com	China	3000	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49391	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29826	58
Wuhan ChemNorm Biotech Co.,Ltd.	+86-27-8439 4403 18971486879	sales@chemnorm.com	CHINA	2935	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	26267	58
LUYUNJIA CHEMISTRY XIAMEN LIMITED	+86-592-5360779 +86-13055435203		China	5996	58

Supplier	Advantage
Shanghai Zheyan Biotech Co., Ltd.	58
Chengdu GLP biotechnology Co Ltd	58
Chengdu Biopurify Phytochemicals Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
Shaanxi Pioneer Biotech Co., Ltd .	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Wuhan ChemNorm Biotech Co.,Ltd.	58
Dideu Industries Group Limited	58
LUYUNJIA CHEMISTRY XIAMEN LIMITED	58

View Lastest Price from Febrifugine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-10	Febrifugine 24159-07-7	US $9.80 / KG	1KG	≥98%	20 tons	Career Henan Chemical Co

Febrifugine
24159-07-7
US $9.80 / KG
≥98%
Career Henan Chemical Co

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Febrifugine β-dichroine 3-(3-(3-Hydroxypiperidin-2-yl)-2-oxopropyl)quinazolin-4(3H)-one Febrifugine，Isofebrifugine 3-[3-[(2R,3S)-3-Hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone BETA-Febrifugine febrifugin 4(3H)-Quinazolinone, 3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]- Radix Dichroae Febrifugine (6-Desoxyswietenine) Febrifugine USP/EP/BP ferifugine (+)-Febrifugine 24159-07-7