ChemicalBook >> CAS DataBase List >>6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-α-ethyl-2,3,9-trimethyl-, (αR,6S)-

6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-α-ethyl-2,3,9-trimethyl-, (αR,6S)-

6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-α-ethyl-2,3,9-trimethyl-, (αR,6S)- structure

CAS No.: 2421153-77-5

Chemical Name:: 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-α-ethyl-2,3,9-trimethyl-, (αR,6S)-

Synonyms: ET-JQ1-OH;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-α-ethyl-2,3,9-trimethyl-, (αR,6S)-;(2R)-2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.02,?]trideca-2(6),4,7,10,12-pentaen-9-yl]butanoic acid

CBNumber:: CB112073510

Molecular Formula:: C21H21ClN4O2S

Molecular Weight:: 428.94

MDL Number:

MOL File:: 2421153-77-5.mol

Last updated:2023-06-30 15:45:59

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6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-α-ethyl-2,3,9-trimethyl-, (αR,6S)- Properties

Boiling point	663.8±65.0 °C(Predicted)
Density	1.44±0.1 g/cm3(Predicted)
solubility	Soluble to 100 mM in DMSO
pka	4.11±0.10(Predicted)

6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-α-ethyl-2,3,9-trimethyl-, (αR,6S)- Chemical Properties,Uses,Production

Biological Activity

(+)-JQ1 bump, acid functionalized is a BET bromodomain binding analog of (+)-JQ1 that selectively binds single point mutant form of Brd4 (Brd4BD2 L387A). Functionalized with a carboxylic acid group to enable onward chemistry. The position of the carboxylic acid group represents an 'exit vector' allowing modification without interfering with compound binding ability.

storage

Store at -20°C

6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-α-ethyl-2,3,9-trimethyl-, (αR,6S)- Preparation Products And Raw materials

Raw materials

Preparation Products

6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-α-ethyl-2,3,9-trimethyl-, (αR,6S)- Suppliers

Global( 5)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou J&H Chemical Co., Ltd.	0571-+86-571-87396432	sales@jhechem.com	China	11280	59
Jilin Province Woda Biotechnology Co., Ltd.	13504435624	1927928688@qq.com	China	1382	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	23962	58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd.	025-66061636 18013972705	qqyang@aikonchem.com	China	8263	58
Elucigen bio	13501719342	wayne.zheng@elucigenbio.com	China	4587	58

Supplier	Advantage
Hangzhou J&H Chemical Co., Ltd.	59
Jilin Province Woda Biotechnology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd.	58
Elucigen bio	58

6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-α-ethyl-2,3,9-trimethyl-, (αR,6S)- ET-JQ1-OH (2R)-2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.02,?]trideca-2(6),4,7,10,12-pentaen-9-yl]butanoic acid 2421153-77-5