ChemicalBook >> CAS DataBase List >>N,N'-bis(salicylideneamino)ethane-manganese(II)
N,N'-bis(salicylideneamino)ethane-manganese(II)
- CAS No.
- 53177-12-1
- Chemical Name:
- N,N'-bis(salicylideneamino)ethane-manganese(II)
- Synonyms
- EUK-8;EUK-8 >=95% (HPLC);Manganese(salen) chloride;(Salen)manganese(III) chloride;(Salen)manganese(III) chloride (EUK-8);Manganese(salen) chloride, 10 mM in DMSO;N,N'-bis(salicylideneamino)ethane-manganese(II);Chloro(bis(salicylidene)ethylenediamine)manganese;Chloro[N,N′-ethylenebis(salicylideneaminato)]manganese;N,N'-Bis(salicylidene)-1,2-ethylenediamine-manganese(II)
- CBNumber:
- CB11380553
- Molecular Formula:
- C16H14ClMnN2O2
- Molecular Weight:
- 356.685609
- MDL Number:
- MOL File:
- 53177-12-1.mol
- MSDS File:
- SDS
Last updated:2025-04-17 18:22:24
N,N'-bis(salicylideneamino)ethane-manganese(II) price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0742 | EUK-8 ≥95% (HPLC) | 53177-12-1 | 10mg | $127 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0742 | EUK-8 ≥95% (HPLC) | 53177-12-1 | 50mg | $482 | 2024-03-01 | Buy |
| Sigma-Aldrich | 341209 | EUK-8 A synthetic salen-manganese complex with high superoxide dismutase (SOD) and catalase-mimic activities, and oxyradical scavenging activities. | 10MG | $125 | 2024-03-01 | Buy | |
| TRC | D493573 | [N,N0-Disalicylidene-1,2-ethanediaminato-(2-)]manganese(III)Chloride | 53177-12-1 | 500mg | $695 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0136655 | CHLORO(BIS(SALICYLIDENE)ETHYLENEDIAMINE)MANGANESE 95.00% | 53177-12-1 | 5MG | $502.72 | 2021-12-16 | Buy |
N,N'-bis(salicylideneamino)ethane-manganese(II) Chemical Properties,Uses,Production
Uses
[N,N 0-Disalicylidene-1,2-ethanediaminato-(2-)]manganese(III) Chloride is an oxidation catalysts and an enzyme mimetic. It also functions as an intermediate in the synthesis of manganese(III) complexes with fluorinated salen derivatives that exhibits antioxidant properties.
Biochem/physiol Actions
EUK-8 is a salen manganese complex that exhibit potent antioxidant activities. EUK-8 is a superoxide dismutase (SOD) that inhibits amyloid fibril formation, including islet amyloid polypeptide (IAPP), β-amyloid and lysozyme amyloid aggregation. It appears that EUK-8 disrupts the pre-formed amyloid fibrils. EUK-8 increases the viability of the SK-N-MC cells exposed to preformed IAPP fibrils.
in vivo
Manganese(salen) chloride (25 mg/kg; i.p. 3 times a week for 4 weeks) reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant[3].
| Animal Model: | Wild-type (WT) and harlequin (Hq) B6CBA male and female mice[3] |
| Dosage: | 25 mg/kg/day |
| Administration: | I.p. 3 times a week for 4 weeks |
| Result: | Prevented myocardial oxidant damage provoked by biomechanical stress. Improved survival following biomechanical stress. Prevented functional and geometrical deterioration in response to pressure overload. Attenuated necrotic and apoptotic cell death, and attenuated cardiac hypertrophy and fibrosis. |
N,N'-bis(salicylideneamino)ethane-manganese(II) Preparation Products And Raw materials
Raw materials
Preparation Products
N,N'-bis(salicylideneamino)ethane-manganese(II) Suppliers
Global( 50)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49732 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | 1015@dideu.com | China | 3978 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Chengdu Forest Science and Technology Development Co., Ltd. | 18030648795 18030648795 | sales@cdforestchem.com | China | 1999 | 58 |
| Shanghai AQBioPharma Co., Ltd. | 13661411401 | yinglv.que@aqbiopharma.com.cn | China | 2840 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51456 | 80 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71829 | 60 |
View Lastest Price from N,N'-bis(salicylideneamino)ethane-manganese(II) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Manganese(salen) chloride
53177-12-1
|
US $39.00-91.00 / mg | 99.14% | 10g | TargetMol Chemicals Inc. |
-
- Manganese(salen) chloride
53177-12-1
- US $39.00-91.00 / mg
- 99.14%
- TargetMol Chemicals Inc.
N,N'-Bis(salicylidene)-1,2-ethylenediamine-manganese(II)
(SP-5-13)-Chloro[[2,2'-[1,2-ethanediylbis[(nitrilo-alphaN)methylidyne]]bis[phenolato-alphaO]](2-)]manganese
(Salen)manganese(III) chloride
(SP-5-13)-Chloro[[2,2′-[1,2-ethanediylbis(nitrilomethylidyne)]bis[phenolato]](2-)-N,N′,O,O′]-manganese
Chloro(bis(salicylidene)ethylenediamine)manganese
Chloro[N,N′-ethylenebis(salicylideneaminato)]manganese
Manganese(salen) chloride
N,N'-bis(salicylideneamino)ethane-manganese(II)
EUK-8
(SP-5-13)-Chloro[[2,2'-[1,2-ethanediylbis[(nitrilo-alphaN)methylidyne]]bis[phenolato-alphaO]](2-)]manganese
N,N'-Bis(salicylidene)-1,2-ethylenediamine-manganese(II)
EUK-8 >=95% (HPLC)
(Salen)manganese(III) chloride (EUK-8)
Manganese(salen),inhibit,dismutase,EUK8,catalase,oxyradical,mimetic,Inhibitor,antioxidant,EUK 8,superoxide,Reactive Oxygen Species,Manganese(salen) chloride,scavenging
Manganese(salen) chloride, 10 mM in DMSO
53177-12-1
C16H14ClMnN2O2