Actisomide
- CAS No.
- 96914-39-5
- Chemical Name:
- Actisomide
- Synonyms
- Actisomide;(4R,4aR)-4-[2-(Diisopropylamino)ethyl]-1-methyl-4-phenyl-4,4a,5,6 ,7,8-hexahydro-3H-pyrido[1,2-c]pyrimidin-3-one;(+/-)-trans-4-<2-
- CBNumber:
- CB11401924
- Molecular Formula:
- C23H35N3O
- Molecular Weight:
- 369.54
- MDL Number:
- MFCD00867093
- MOL File:
- 96914-39-5.mol
| Melting point | 201-202 °C(Solv: ethyl ether (60-29-7)) |
|---|---|
| Boiling point | 473.9±55.0 °C(Predicted) |
| Density | 1.08±0.1 g/cm3(Predicted) |
| pka | 10.51±0.28(Predicted) |
| FDA UNII | IJQ29N87NR |
Actisomide Chemical Properties,Uses,Production
Originator
Dizactamide ,ZYF Pharm Chemical
Manufacturing Process
Hydrogenation of 4-diisopropylamino-2-phenyl-2-pyridin-2-yl-butyramide over
platinum oxide catalyst reduced the pyridine ring to a piperidine to give 4-
diisopropylamino-2-phenyl-2-piperidin-2-yl-butyramide as a white solid, MP:
107°-108°C. Structure was confirmed by proton, carbon-13-NMR spectra and
by elemental analysis.
2-(1-Acetylpiperidin-2-yl)-4-diisopropylamino-2-phenylbutyramide was
prepared by acetylation of above product with N,N-dimethylacetamide
dimethylacetal by heating at 80°C for about 14 hours. The acetamide melted
at 191°-192°C. The treatment of that intermediate with lithium aluminum
hydride led the newly introduced acetyl group to condense with the adjacent
amide nitrogen. There was thus obtained 4-(2-diisopropylaminoethyl)-1-
methyl-4-phenyl-4,4a,5,6,7,8-hexahydropyrido[1,2-c]pyrimidin-3-one, the
new anti-arrhythmic agent actisomide, MP: 70°-75°C. Its structure was
confirmed by proton NMR and infrared spectra and by elemental analysis.
brand name
Cardiac depressant (anti-arrhythmic).
Therapeutic Function
Cardiac depressant
Actisomide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 | czbjpharma@126.com | China | 18488 | 58 |
| Supplier | Advantage |
|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 58 |
| Changzhou Bojia Biomedical Technology Co., Ltd. | 58 |