N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA
- CAS No.
- 792173-99-0
- Chemical Name:
- N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA
- Synonyms
- CS-1891;SB334867/SB-334867;SB334867A free base;SB-334867,CID 6604926;SB-334867 (free base);SB-334867 >=98% (HPLC);SB 334867, OX1 receptor antagonist;N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl;N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA;Urea, N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl-
- CBNumber:
- CB11519689
- Molecular Formula:
- C17H13N5O2
- Molecular Weight:
- 319.32
- MDL Number:
- MFCD06411602
- MOL File:
- 792173-99-0.mol
- MSDS File:
- SDS
| Boiling point | 450.5±30.0 °C(Predicted) |
|---|---|
| Density | 1.472 |
| storage temp. | room temp |
| solubility | insoluble in H2O; insoluble in EtOH; ≥14.55 mg/mL in DMSO |
| form | powder |
| pka | 10.21±0.43(Predicted) |
| color | white to beige |
| CAS DataBase Reference | 792173-99-0 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P332+P313-P362+P364 | |||||||||
| NFPA 704 |
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N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1530 | SB-334867 ≥98% (HPLC) | 792173-99-0 | 5MG | $131 | 2023-06-20 | Buy |
| Sigma-Aldrich | SML1530 | SB-334867 ≥98% (HPLC) | 792173-99-0 | 25MG | $530 | 2023-06-20 | Buy |
| Cayman Chemical | 19145 | SB-334867 | 792173-99-0 | 1mg | $25 | 2024-03-01 | Buy |
| Cayman Chemical | 19145 | SB-334867 | 792173-99-0 | 5mg | $75 | 2024-03-01 | Buy |
| Cayman Chemical | 19145 | SB-334867 | 792173-99-0 | 10mg | $138 | 2024-03-01 | Buy |
N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA Chemical Properties,Uses,Production
Uses
SB 334867 is an orexin 1 receptor antagonist.
Definition
ChEBI: 1-(2-methyl-1,3-benzoxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea is a naphthyridine derivative.
Biological Activity
sb-334867 free base is a selective antagonist of orexin-1 receptor [1].orexin-a and orexin-b are two peptides isolated from rat hypothalamus. they are involved in some physiological functions such as the control of feeding, energy metabolism and regulation of the sleep-wake cycle.sb-334867 free base could inhibit the orexin-a and orexin-b induced calcium responses in cho-ox1 cells with pkb values of 7.27 and 7.23, respectively. sb-334867 was more selective for ox1 receptor over ox2 receptor. it caused 32.7% and 22% inhibition of orexin-a and orexin-b induced calcium responses in cho-ox2 cells, respectively. moreover, sb-334867 was found to reduce both orexin-a-induced and fasting-induced food intake. the acute anorectic effect of it was associated with significant reductions in all active behaviours [1, 2].
Biochem/physiol Actions
Lateral hypothalamic orexin neuron activation leads to the development of morphine conditioned place preference, which is preferably blocked by SB-334867.
storage
Room temperature (desiccate)
References
[1] smart d, sabido-david c, brough s j, et al. sb-334867-a: the first selective orexin-1 receptor antagonist. british journal of pharmacology, 2001, 132(6): 1179-1182.
[2] rodgers r j, halford j c g, nunes de souza r l, et al. sb-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-a in rats. european journal of neuroscience, 2001, 13(7): 1444-1452.
N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32956 | 60 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Shanghai Safer Pharmaceutical Technology Co., Ltd. | 021-31761238 | sales@saferph.com | CHINA | 897 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30237 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22787 | 58 |
| Shenzhen Shengda Pharma Limited | 755-85269922 +8613424394241 | sales@shengdapharm.com | CHINA | 310 | 58 |
| Henan Alfa Chemical Co., Ltd | China | 11865 | 58 | ||
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 |