DIMETHYL DL-GLUTAMATE HYDROCHLORIDE
- CAS No.
- 13515-99-6
- Chemical Name:
- DIMETHYL DL-GLUTAMATE HYDROCHLORIDE
- Synonyms
- utamate HydrochL;H-DL-Glu(Ome)-Ome;DL-Glu(OMe)-OMe.HCl;H-DL-GLU(OME)-OME HCL;DIMETHYL DL-GLUTAMATE HYDROCHLORIDE;DimethylDL-GlutamateHydrochloride>imethyl2-aminopentanedioate,hydrochloride;dimethyl 2-aminopentanedioate hydrochloride;DL-GLUTAMIC ACID DIMETHYL ESTER HYDROCHLORIDE;DIMETHYL DL-GLUTAMATE HYDROCHLORIDE USP/EP/BP
- CBNumber:
- CB1152575
- Molecular Formula:
- C7H14ClNO4
- Molecular Weight:
- 211.64
- MDL Number:
- MFCD00266895
- MOL File:
- 13515-99-6.mol
- MSDS File:
- SDS
| Melting point | 154 °C |
|---|---|
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO (Slightly, Sonicated), Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| CAS DataBase Reference | 13515-99-6 |
| FDA UNII | 16247QSY33 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501 | |||||||||
| HS Code | 2922.42.5000 | |||||||||
| NFPA 704 |
|
DIMETHYL DL-GLUTAMATE HYDROCHLORIDE price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D3305 | Dimethyl DL-Glutamate Hydrochloride >98.0%(N)(T) | 13515-99-6 | 5g | $42 | 2024-03-01 | Buy |
| TCI Chemical | D3305 | Dimethyl DL-Glutamate Hydrochloride >98.0%(N)(T) | 13515-99-6 | 25g | $120 | 2024-03-01 | Buy |
| Cayman Chemical | 18602 | Dimethyl DL-Glutamate (hydrochloride) ≥95% | 13515-99-6 | 5g | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 18602 | Dimethyl DL-Glutamate (hydrochloride) ≥95% | 13515-99-6 | 10g | $130 | 2024-03-01 | Buy |
| Cayman Chemical | 18602 | Dimethyl DL-Glutamate (hydrochloride) ≥95% | 13515-99-6 | 25g | $302 | 2024-03-01 | Buy |
DIMETHYL DL-GLUTAMATE HYDROCHLORIDE Chemical Properties,Uses,Production
Description
While extracellular glutamic acid is an excitatory neurotransmitter, intracellular glutamic acid is an amino acid that serves numerous metabolic roles. Dimethyl DL-glutamate is a cell-permeant glutamic acid derivative that enhances insulin release in response to glucose in isolated islets and in animal models of diabetes. It also potentiates the insulinotropic potential of glyburide and glucagon-like peptide 1. Dimethyl DL-glutamate is used as a cell-permeable form of glutamate in studies of glutamate action in β-cells. However, it can be cytotoxic to myeloid cells and act as an antagonist of glutamate-mediated neurosignaling.
Uses
While extracellular glutamic acid is an excitatory neurotransmitter, intracellular glutamic acid is an amino acid that serves numerous metabolic roles. Dimethyl DL-glutamate Hydrochloride is a cell-permeant glutamic acid derivative that enhances insulin release in response to glucose in isolated islets and in animal models of diabetes. It also potentiates the insulinotropic potential of glyburide and glucagon-like peptide 1. Dimethyl DL-glutamate Hydrochloride is used as a cell-permeable form of glutamate in studies of glutamate action in β-cells. However, it can be cytotoxic to myeloid cells and act as an antagonist of glutamate-mediated neurosignaling.
in vitro
dimethyl dl-glutamate at 3.0-10.0 mm could enhance insulin release evoked by 6.0-8.3 mm d-glucose, 1.0-10.0 mm l-leucine, or 5.0-10.0 mm 2-amino-bicyclo(2,2,1)heptane-2-carboxylic acid, resulting in a shift to the left of the sigmoidal relationship between insulin output and d-glucose concentration. moreover, dimethyl dl-glutamate unmasked the insulinotropic potential of glibenclamide in the absence of d-glucose. in islets exposed to l-leucine, the insulinotropic action of dimethyl dl-glutamate coincided with an early fall and later increase in 86rb outflow. in addition, the overall gain in o2 uptake represented the balance between dimethyl dl-glutamate oxidation and its sparing action on the catabolism of endogenous fatty acids and exogenous d-glucose [1].
in vivo
dimethyl dl-glutamate was intravenously administered as a primed constant infusion to adult rats that had been injected with streptozotocin during the neonatal period. results showed that dimethyl dl-glutamate augmented plasma insulin concentration and potentiated and/or prolonged the insulinotropic action of glp-1 injected intravenously at min 5 of the test [2].
References
[1] sener, a. ,conget, i.,rasschaert, j., et al. insulinotropic action of glutamic acid dimethyl ester. american journal of physiology 267(4 pt 1), e573-e584 (1994).
[2] cancelas, j. ,villaneuva-peacarrillo, m.l.,valverde, i., et al. potentiation and prolongation of the insulinotropic action of glucagon-like peptide 1 by methyl pyruvate or dimethyl ester of l-glutamic acid in a type 2 diabetes animal model. endocrine 16(2), 113-116 (2001).
DIMETHYL DL-GLUTAMATE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan HongRi Pharma-Tech Co.,Ltd | +86-028-64841719 +8617390183901 | daisy@enlaibio.com | China | 1106 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29730 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29858 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32202 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| GL Biochem (Shanghai) Ltd. | +86-021-61263370 +86-18901917034 | CHINA | 3904 | 58 |
View Lastest Price from DIMETHYL DL-GLUTAMATE HYDROCHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-28 | DL-Glu(Ome)-Ome.Hcl
13515-99-6
|
US $0.00-0.00 / kg | 1kg | 98% | 1T+ | Sichuan HongRi Pharma-Tech Co.,Ltd | |
 |
2024-11-19 | Dimethyl DL-Glutamate (hydrochloride)
13515-99-6
|
US $29.00 / g | ≥95% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-07-06 | DIMETHYL DL-GLUTAMATE HYDROCHLORIDE
13515-99-6
|
US $1.00 / KG | 1KG | 99% | 20kg | Career Henan Chemical Co |
-
- DL-Glu(Ome)-Ome.Hcl
13515-99-6
- US $0.00-0.00 / kg
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- Dimethyl DL-Glutamate (hydrochloride)
13515-99-6
- US $29.00 / g
- ≥95%
- TargetMol Chemicals Inc.
-
- DIMETHYL DL-GLUTAMATE HYDROCHLORIDE
13515-99-6
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
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