Methyl nicotinate
- CAS No.
- 93-60-7
- Chemical Name:
- Methyl nicotinate
- Synonyms
- NICOTINIC ACID METHYL ESTER;METHYL PYRIDINE-3-CARBOXYLATE;Nikomet;METHYL 3-PYRIDINECARBOXYLATE;Nicometh;FEMA 3709;Methyl niacin;Methyl nictinate;AKOS BBS-00004415;METHYL NICOTINATE
- CBNumber:
- CB1173538
- Molecular Formula:
- C7H7NO2
- Molecular Weight:
- 137.14
- MDL Number:
- MFCD00006388
- MOL File:
- 93-60-7.mol
- MSDS File:
- SDS
| Melting point | 42-44 °C (lit.) |
|---|---|
| Boiling point | 204 °C (lit.) |
| Density | 1.2528 (rough estimate) |
| vapor pressure | 0.4 hPa (25 °C) |
| refractive index | 1.5323 (estimate) |
| FEMA | 3709 | METHYL NICOTINATE |
| Flash point | 204 °F |
| storage temp. | Store below +30°C. |
| solubility | H2O: 0.1 g/mL, clear |
| pka | pKa 3.1 (Uncertain) |
| form | Crystals or Crystalline Powder |
| color | White to brownish |
| Odor | at 10.00 % in dipropylene glycol. warm herbal tobacco |
| Odor Type | herbal |
| Water Solubility | NEGLIGIBLE |
| Merck | 14,6100 |
| JECFA Number | 1320 |
| BRN | 113951 |
| InChIKey | YNBADRVTZLEFNH-UHFFFAOYSA-N |
| LogP | 0.68 at 25℃ |
| CAS DataBase Reference | 93-60-7(CAS DataBase Reference) |
| Substances Added to Food (formerly EAFUS) | METHYL NICOTINATE |
| FDA 21 CFR | 310.545 |
| EWG's Food Scores | 1 |
| FDA UNII | 7B1AVU9DJN |
| NIST Chemistry Reference | Methyl nicotinate(93-60-7) |
| EPA Substance Registry System | Methyl nicotinate (93-60-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-36/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | QT1925000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29333999 | |||||||||
| Toxicity | LD50 orally in Rabbit: > 2000 mg/kg | |||||||||
| NFPA 704 |
|
Methyl nicotinate price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | W370908 | Methyl Nicotinate ≥99%, FG | 93-60-7 | 5kg | $678 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.18713 | Methyl nicotinate for synthesis | 93-60-7 | 100g | $45.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.18713 | Methyl nicotinate for synthesis | 93-60-7 | 500g | $159 | 2024-03-01 | Buy |
| Sigma-Aldrich | 72420 | Methyl nicotinate puriss., ≥99.0% (GC) | 93-60-7 | 100g | $45.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | 69193 | Methyl nicotinate AldrichCPR | 93-60-7 | 100mg | $173 | 2022-05-15 | Buy |
Methyl nicotinate Chemical Properties,Uses,Production
Description
Methyl nicotinate is a skin irritant in man, in particular producing vasodilatation, which is used on purpose in “rubefacient”, to produce a redness or inflammation for a short period of time, often in lip plumper or other lip products. Methyl nicotinate is also an active ingredient of a number of veterinary preparations intended for topical application as a rubefacient for the treatment of a variety of diseases, such as respiratory diseases, vascular disorders (oedema, haematoma), and rheumatoid disorders in cattle and horses (doses not stated; the concentration in the formulated veterinary medicinal product is 2%).
Chemical Properties
Methyl nicotinate is white to brownish crystals or crystalline powder and has a fresh, caramellic, nutty and mild tobacco odor.
Occurrence
Reported found in ground coffee, roasted filberts, guanabana (Annona muicata L.), roasted peanuts, wild strawberries, vanilla bean, papaya, guava, plum, beer cognac, soursop, malt, wort, Bourbon vanilla and mountain papaya.
Uses
Methyl nicotinate (MN) is the methyl ester of nicotinic acid that is used as an active ingredient, a rubefacient and counter-irritant in over-the-counter topical preparations indicated for the temporary relief of aches and pains in muscles,tendons, and joints. The action of methyl nicotinate as a rubefacient is thought to involve peripheral vasodilation.For veterinary purposes，methyl nicotinate is used to treat respiratory diseases, vascular disorders, rheumatoid arthritis, and muscle and joint pains.Methyl nicotinate can be found in in guava fruit, papaya, strawberry, soursop(Annona muricata), beer, grape brandy, coffee, roasted filbert, roasted peanut and Bourbon vanilla.
Application
Methyl nicotinate can be employed as a precursor in the synthesis:
Di-3-pyridyl ketone ligand, which is used in the preparation of silver(I) complexes for the derivation of coordination polymeric chains.
5-arylnicotinates , ±-sesbanine , and 1,4-dihydropyridine derivatives.
Preparation
Methyl nicotinate was prepared by esterification of nicotinic acid by refluxing with methanol in the presence of concentrated sulphuric acid, esterification product obtained was extracted into organic solvent (chloroform) after neutralization of the reaction mixture with 10% sodium bicarbonate.
Synthesis and antinociceptive activity of methyl nicotinate
DOI:10.4314/jpb.v12i1.8
Definition
ChEBI: Methyl nicotinate is a member of pyridines and an aromatic carboxylic acid.
General Description
Methyl nicotinate (or nicotinic acid methyl ester) is used as a rubefacient for the relief of pains in muscles, tendons, and joints. It is also used in food as a flavoring agent.
Side effects
There is presently no side effect information available for Methyl nicotinate(MN) itself. a few patients who applied a medicated topical preparation containing MN (and other components) suffered adverse reactions including faintness, nausea, pain and skin rashes.
Safety
No data are available for chronic toxicity of Methyl nicotinate(MN) in humans. No adverse effects were reported for nicotinamide in clinical studies, whereas high doses of NA (3000 mg/day) are associated with considerable toxicity. In one third to one half of the 1119 patients taking 3000 mg NA /day for at least five years (to reduce the incidence of a second myocardial infarction), side effects included gastrointestinal and urinary tract problems, as well as dermatological problems of flushing, itching and rash ("The Coronary Drug Project", 1975, cited in "monograph of methyl nicotinate", Council of Europe, 2008, pp. 248).
Synthesis
Methyl nicotinate is synthesized from Nicotinyl chloride hydrochloride and and Methanol in presence of Pyridine.
Carcinogenicity
No data on the mutagenic or carcinogenic potential of methyl nicotinate were presented. However life-time studies in mice employing doses of 2 to 3 mg nicotinamide/kg bw/day gave no indication of carcinogenic potential.
Methyl nicotinate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Terma Medicare India Pvt.,Ltd | +8613916485955 | shivshanghai@yahoo.com | India | 172 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8810 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5889 | 58 |
| Anhui Zhongda Biotechnology Co., Ltd | +8619956560829 | justine@zhongda-biotech.com | China | 286 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20284 | 58 |
| airuikechemical co., ltd. | +undefined86-15315557071 | sales02@sdzhonghuimaterial.com | China | 983 | 58 |
| hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 970 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3002 | 58 |
| Shandong Deshang Chemical Co., Ltd. | +86-0531-8875-2665 +8613153039501 | info@deshangchem.com | China | 662 | 58 |
| JINING XINHE CHEMICAL CO., LTD | +8615318402391 | sales@xinhepharma.com | China | 809 | 58 |
View Lastest Price from Methyl nicotinate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-12-20 | Methyl nicotinate
93-60-7
|
US $78.00-35.00 / kg | 1kg | 99% | 20ton | Hebei Zhuanglai Chemical Trading Co.,Ltd | |
 |
2024-12-17 | Methyl nicotinate
93-60-7
|
US $30.00 / kg | 1kg | 99.9% | 500 | hebei hongtan Biotechnology Co., Ltd | |
 |
2024-12-13 | Methyl nicotinate
93-60-7
|
US $0.00 / Kg/Drum | 1KG | 99%min | 1000KGS | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- Methyl nicotinate
93-60-7
- US $78.00-35.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co.,Ltd
-
- Methyl nicotinate
93-60-7
- US $30.00 / kg
- 99.9%
- hebei hongtan Biotechnology Co., Ltd
-
- Methyl nicotinate
93-60-7
- US $0.00 / Kg/Drum
- 99%min
- WUHAN FORTUNA CHEMICAL CO., LTD