3-Indolepropionic acid
- CAS No.
- 830-96-6
- Chemical Name:
- 3-Indolepropionic acid
- Synonyms
- PROPAN-2-OL;INDOLE-3-PROPIONIC ACID;3-(1H-INDOL-3-YL)PROPANOIC ACID;ISOPROPANE;ISOPROPYL ALCOHO;ISOPROPANOL ALCOHOL;INDOLEPROPIONIC ACID;2-PPROPANOL;FEMA 2929;ISOPROPANO
- CBNumber:
- CB1183728
- Molecular Formula:
- C11H11NO2
- Molecular Weight:
- 189.21
- MDL Number:
- MFCD00005660
- MOL File:
- 830-96-6.mol
- MSDS File:
- SDS
Melting point | ~133 °C |
---|---|
Boiling point | 82 °C(lit.) |
Density | 0.960 g/mL at 20 °C |
vapor density | 2.1 (vs air) |
vapor pressure | 33 mm Hg ( 20 °C) |
refractive index |
n |
Flash point | 53 °F |
storage temp. | Sealed in dry,Room Temperature |
solubility | ethanol: soluble50mg/mL, clear, yellow to orange |
pka | 4.77±0.10(Predicted) |
form | crystalline |
color | light yellow |
Water Solubility | slightly soluble |
BRN | 147733 |
CAS DataBase Reference | 830-96-6(CAS DataBase Reference) |
EWG's Food Scores | 1 |
FDA UNII | JF49U1Q7KN |
NIST Chemistry Reference | Indole-3-propionic acid(830-96-6) |
EPA Substance Registry System | 1H-Indole-3-propanoic acid (830-96-6) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 22-36/37/38 | |||||||||
Safety Statements | 26-37/39 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | NM1329000 | |||||||||
F | 8-10-23 | |||||||||
TSCA | Yes | |||||||||
HS Code | 29339990 | |||||||||
Toxicity | LDLo intraperitoneal in mouse: 100mg/kg | |||||||||
NFPA 704 |
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3-Indolepropionic acid price More Price(39)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 57410 | Indole-3-propionic acid ≥97.0% (T) | 830-96-6 | 25g | $116 | 2024-03-01 | Buy |
Sigma-Aldrich | 57410 | Indole-3-propionic acid ≥97.0% (T) | 830-96-6 | 100g | $208 | 2024-03-01 | Buy |
Sigma-Aldrich | 220027 | 3-Indolepropionic acid ReagentPlus , 99% | 830-96-6 | 1g | $30.7 | 2024-03-01 | Buy |
Sigma-Aldrich | 57400 | Indole-3-propionic acid ≥99.0% (T) | 830-96-6 | 5G | $109 | 2024-03-01 | Buy |
Sigma-Aldrich | 220027 | 3-Indolepropionic acid ReagentPlus , 99% | 830-96-6 | 10g | $89.7 | 2024-03-01 | Buy |
3-Indolepropionic acid Chemical Properties,Uses,Production
Description
Indole-3-propionic acid is a bacterial metabolite that has antioxidant and neuroprotective activities. It scavenges ABTS radicals in a cell-free assay when used at concentrations ranging from 50 to 150 μM and decreases hydrogen peroxide-induced malondialdehyde (MDA) levels in rat striatal membranes (IC50 = 180 μM). Indole-3-propionic acid also decreases increases in MDA levels induced by amyloid β (1-42) in PC12 cells. It decreases ischemia-induced increases in cell death of pyramidal neurons and levels of 4-hydroxy nonenal (HNE; ) and glial fibrillary acidic protein (GFAP) in the hippocampal CA1 region in gerbils when administered at a dose of 10 mg/kg per day.
Chemical Properties
pale yellow to yellow crystalline powder
Uses
Reactant for preparation of:
- Fluorescent analogues of strigolactones
- Anti-tumor agents
- Melanocortin receptors ligands
- Immunosuppressive agents
- Iinhibitors of hepatitis C virus
- Histamine H4 receptor agonists
- NR2B/NMDA receptor antagonists
- CB1 antagonist for the treatment of obesity
- Antibacterial agents
- Inhibitor of TGF-β receptor binding
Uses
3-Indolepropionic acid is a deamination product of Tryptophan (T947200) that protects the hippocampus (studied in gerbils) from ischemic damage and oxidative stress. It’s ability to protect the neurons in this way is attributed to its potent antioxidative effects. 3-Indolepropionic acid is also hypothesized to have protective effects on the thyroid gland.
Definition
ChEBI: An indol-3-yl carboxylic acid that is propionic acid substituted by a 1H-indol-3-yl group at position 3.
Synthesis Reference(s)
Tetrahedron Letters, 25, p. 3159, 1984 DOI: 10.1016/S0040-4039(01)90997-9
General Description
3-Indolepropionic acid is an effective inhibitor of aggregation of misfolded β-amyloid protein (Abeta). Three-component one-pot procedure has been reported to assemble 3-indolepropionic acids.
Biochem/physiol Actions
Studied as an adjunct to improve perfusion after liver transplant.
Purification Methods
Recrystallise it from EtOH/water [James & Ware J Phys Chem 89 5450 1985]. The picrate has m 143-144o, and the methyl ester crystallises from *C6H6 or MeOH with m 81-83o. [Beilstein 22 III/IV 1113, 22/3 V 114.]
3-Indolepropionic acid Preparation Products And Raw materials
Raw materials
1of4
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12450 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1807 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29894 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8822 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
View Lastest Price from 3-Indolepropionic acid manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2024-08-22 | 3-Indolepropionic acid
830-96-6
|
US $0.00-0.00 / KG | 1KG | 98.0% | 500kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
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2024-08-20 | 3-Indolepropionic acid
830-96-6
|
US $196.00 / KG | 1KG | 98% | 1-20mt | Baoji Guokang Bio-Technology Co., Ltd. | |
![]() |
2023-09-06 | 3-Indolepropionic acid
830-96-6
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd |
-
- 3-Indolepropionic acid
830-96-6
- US $0.00-0.00 / KG
- 98.0%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 3-Indolepropionic acid
830-96-6
- US $196.00 / KG
- 98%
- Baoji Guokang Bio-Technology Co., Ltd.
-
- 3-Indolepropionic acid
830-96-6
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd