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CEFADROXIL

CEFADROXIL structure

CAS No.: 50370-12-2

Chemical Name:: CEFADROXIL

Synonyms: cdx;duricef;Ultracef;cephadroxil;(6R,7R)-7-[[(R)-Amino(p-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;s-578;Roxil;Evacef;Neucef;NSC438

CBNumber:: CB1203657

Molecular Formula:: C16H17N3O5S

Molecular Weight:: 363.39

MDL Number:: MFCD00865091

MOL File:: 50370-12-2.mol

Last updated:2024-11-15 19:19:13

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CEFADROXIL Properties

Melting point	197°C (rough estimate)
Boiling point	238°C (rough estimate)
Density	1.59
refractive index	1.6390 (estimate)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	Water:9.17(Max Conc. mg/mL);25.23(Max Conc. mM)
pka	3.12±0.50(Predicted)
form	powder or crystals
color	White to off-white
InChIKey	BOEGTKLJZSQCCD-UEKVPHQBSA-N
CAS DataBase Reference	50370-12-2
FDA UNII	Q525PA8JJB

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS08
Signal word	Danger
Hazard statements	H315-H317-H319-H334-H335
Precautionary statements	P280-P302+P352-P305+P351+P338
Hazard Codes	Xn
Risk Statements	36/37/38-42/43
Safety Statements	26-36
WGK Germany	2
RTECS	XI0337000

CEFADROXIL price More Price(11)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C7020	Cefadroxil analytical standard	50370-12-2	1g	$61.4	2024-03-01	Buy
Sigma-Aldrich	C7020	Cefadroxil analytical standard	50370-12-2	5g	$193	2024-03-01	Buy
TRC	C235778	Cefadroxil	50370-12-2	2.5g	$115	2021-12-16	Buy
AK Scientific	J10293	Cefadroxil	50370-12-2	100mg	$37	2021-12-16	Buy
ChemScene	CS-4696	Cefadroxil 98.49%	50370-12-2	100mg	$60	2021-12-16	Buy

Product number	Packaging	Price	Buy
C7020	1g	$61.4	Buy
C7020	5g	$193	Buy
C235778	2.5g	$115	Buy
J10293	100mg	$37	Buy
CS-4696	100mg	$60	Buy

CEFADROXIL Chemical Properties,Uses,Production

Description

Cephadroxil is an orally administered antibiotic, which is very similar to cephalexin. After oral administration, its peak serum level is slightly lower than that of cephalexin, but it is excreted more slowly. Therefore, it can be used for oral administration at 8- or 12-hourly intervals (Buck and Price, 1977; Pfeffer et al., 1977). Cephadroxil is still available in a number of European countries (for example, Spain, Belgium, Luxembourg, Portugal, and Finland, among others).

Chemical Properties

Cefadroxil is a light orange colored powder. It is a cephalosporin antibiotic and is used for the treatment of bacterial infections. Cefadroxil is stable under recommended storage conditions. Cefadroxil is not considered hazardous when handled under normal medical conditions and with good housekeeping

Originator

Oracefal,Bristol,France,1977

Uses

Antibacterial;Bacterial transpeptidase inhibitor

Definition

ChEBI: A cephalosporin bearing methyl and (2R)-2-amino-2-(4-hydroxyphenyl)acetamido groups at positions 3 and 7, respectively, of the cephem skeleton.

Manufacturing Process

1.8 g of sodium N-(1-methoxycarbonyl-1-propen-2-yl)-D(-)-α-amino-(4- hydroxyphenyl)acetate was suspended in 10 ml of acetone, and one droplet of N-methylmorpholine was added thereto, and the mixture was cooled to -15°C.There was added 0.85 g of ethyl chlorocarbonate thereto, and the mixture was reacted at -13°C to -10°C for 30 minutes, and then the reaction solution was cooled to -20°C.
On the other hand, 1 g of 7-amino-3-methyl-3-cephem-4-carboxylic acid was suspended in 20 ml of methanol, and 1.4 g of triethylamine was added thereto to be dissolved, and 0.4 ml of acetic acid was further added thereto. This solution was cooled to -20°C and the mixed acid anhydride prepared previously was added thereto. After the mixture was reacted at -20°C for 1 hour, the temperature of the reaction mixture was raised to 0°C over a period of 1 hour, and the mixture was reacted for 3 hours at the same temperature.
After the reaction, 1 ml of water was added to the reaction mixture, and the mixture was adjusted to a pH of 1.0 with concentrated hydrochloric acid while being cooled, and then stirred for 30 minutes, The insoluble matters were filtered off, and the filtrate was adjusted to a pH of 5.5 with triethylamine. This solution was concentrated under reduced pressure, and the residue was diluted with 20 ml of acetone to precipitate white crystals. The crystals were collected by filtration and washed with ethanol to obtain 1.46 g of white crystals of 7-[D(-)-α-amino-(4-hydroxyphenyl)acetamido]-3-methyl-3- cephem-4-carboxylic acid having a decomposition point of 197°C.

Therapeutic Function

Antibacterial

Health Hazard

Exposures to cefadroxil cause certain common side effects. These include nausea, vomiting, stomach disorders, rashes, itching, unusual tiredness or weakness, yellowing of the skin or eyes, red, swollen, or blistered skin, unusual bruising or bleeding, sore throat, respiratory distress, tightness in the chest, swelling of the mouth, face, lips, or tongue, decreased urination, dark urine, vaginal itching, odor, or discharge, fever, chills, joint pain, and seizures. Prolonged or long-term use of cefadroxil should be avoided.

Precautions

Cefadroxil should be used only under proper medical health care since it has properties of penicillin allergy, renal function, gastrointestinal tract damage. Pregnant women and breast-feeding women should avoid exposure to cefadroxil.

CEFADROXIL Preparation Products And Raw materials

Raw materials

7-Amino-3-methyl-3-cephem-4-carboxylic acid Ethyl chloroformate

Preparation Products

3-Hydroxy-4-Methyl-2(5H)-thiophenone

CEFADROXIL Suppliers

Global( 132)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618092446649	sarah@tnjone.com	China	1143	58
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9215	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29884	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32080	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10319	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34553	58
HONG KONG IPURE BIOLOGY CO.,LIMITED	86 18062405514 18062405514	ada@ipurechemical.com	CHINA	3461	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22883	58

Supplier	Advantage
Shaanxi TNJONE Pharmaceutical Co., Ltd	58
Hangzhou FandaChem Co.,Ltd.	55
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Hubei Ipure Biology Co., Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
HONG KONG IPURE BIOLOGY CO.,LIMITED	58
Dideu Industries Group Limited	58

View Lastest Price from CEFADROXIL manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-15	Cefadroxil 50370-12-2	US $36.00-58.00 / mg		98.91%	10g	TargetMol Chemicals Inc.
2024-11-15	Cefadroxil 50370-12-2	US $36.00-58.00 / mg		98.91%	10g	TargetMol Chemicals Inc.
2024-04-10	Cefprozil Impurity B 50370-12-2	US $0.00-0.00 / mg	10mg	90%+	10g	Guangzhou PI PI BIOTECH INC

Cefadroxil
50370-12-2
US $36.00-58.00 / mg
98.91%
TargetMol Chemicals Inc.

Cefadroxil
50370-12-2
US $36.00-58.00 / mg
98.91%
TargetMol Chemicals Inc.

Cefprozil Impurity B
50370-12-2
US $0.00-0.00 / mg
90%+
Guangzhou PI PI BIOTECH INC

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(6R,7R)-7-[(R)-2-AMINO-2-(4-HYDROXY-PHENYL)-ACETYLAMINO]-3-METHYL-8-OXO-5-THIA-1-AZA-BICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID CEFAMOX (6r-(6-alpha,7-beta(r*)))-l)acetyl)amino)-3-methyl-8-oxo P-HYDROXYCEPHALEXINE 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid,7-((amino(4-hydroxypheny bidocef bl-s578 oracefal s-578 5-Thia-1-azabicyclo4.2.0oct-2-ene-2-carboxylic acid, 7-(2R)-amino(4-hydroxyphenyl)acetylamino-3-methyl-8-oxo-, (6R,7R)- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[amino(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-, [6R-[6α,7β(R*)]]- D-Cefadroxil Cefadroxil(anhydrous) (6R,7R)-7-[[(2R)-2-Amino-2-(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Cefadrox Cefadur Cipadur Evacef Helicef Ibidroxil Neucef Roxil Sumacef Cefprozil Monohydrate EP Impurity B 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-, (6R,7R)- Cefadroxil Capsule USP/EP/BP Cefprozil Impurity B CefadroxilQ: What is Cefadroxil Q: What is the CAS Number of Cefadroxil Q: What is the storage condition of Cefadroxil Q: What are the applications of Cefadroxil NSC 438 NSC438 NSC-438 cdx cephadroxil duricef (6R,7R)-7-[[(R)-Amino(p-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Ultracef Cefprozil Impurity B(EP) Caprylic Acid Impurity 75 50370-12-2 Alphabetic Analytical Chromatography Product Catalog Analytical Standards CA - CG Active Pharmaceutical Ingredients Alphabetic C CA - CGForensic and Veterinary Standards Drugs&Metabolites Neat Compounds cephalosporins