α-MSH (11-13) (free acid)
- CAS No.
- 67727-97-3
- Chemical Name:
- α-MSH (11-13) (free acid)
- Synonyms
- KPV;msh(11-13;ACTH-(11-13);H-Lys-Pro-Val-OH;ALPHA-MSH (11-13);α-MSH(11-13)[pig];α-MSH(11-13)[human];H-LYS-PRO-VAL-OH ACOH;α-Melanotropin(11-13);alpha-MSH(11-13) acetate
- CBNumber:
- CB1241534
- Molecular Formula:
- C16H30N4O4
- Molecular Weight:
- 342.43
- MDL Number:
- MFCD00804591
- MOL File:
- 67727-97-3.mol
- MSDS File:
- SDS
storage temp. | -15°C |
---|---|
InChI | InChI=1S/C16H30N4O4/c1-10(2)13(16(23)24)19-14(21)12-7-5-9-20(12)15(22)11(18)6-3-4-8-17/h10-13H,3-9,17-18H2,1-2H3,(H,19,21)(H,23,24)/t11-,12-,13-/m0/s1 |
InChIKey | YSPZCHGIWAQVKQ-AVGNSLFASA-N |
SMILES | C(O)(=O)[C@H](C(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)N |
α-MSH (11-13) (free acid) price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
American Custom Chemicals Corporation | PRO0001392 | ALPHA-MSH (11-13) ACETATE SALT 95.00% | 67727-97-3 | 5MG | $504.86 | 2021-12-16 | Buy |
AHH | MT-19210 | alpha-Msh(11-13)(freeacid)acetatesalt 98% | 67727-97-3 | 0.25g | $898 | 2021-12-16 | Buy |
α-MSH (11-13) (free acid) Chemical Properties,Uses,Production
Definition
ChEBI: Lys-Pro-Val is an oligopeptide.
Biological Activity
The C-terminal tripeptide α-MSH(11–13), also known as KPV (L-Lys-L-Pro-L-Val), exhibited anti-inflammation without induction of cutaneous pigmentation in a frog skin bioassay. The underlying molecular mechanisms of the α-MSH(11–13) anti-inflammatory properties have not been determined in detail. However, they are related to an inhibition of TNF-α, IL-6, and nitric oxide production in a model of LPS-stimulated murine microglial cell culture[1]. Furthermore, it has been recently shown that α-MSH(11–13) reduces activation of NF-κB and decreases its translocation into the nucleus by interaction with importin family proteins.
References
[1] Eva-Verena Schaible. “Single administration of tripeptide α-MSH(11-13) attenuates brain damage by reduced inflammation and apoptosis after experimental traumatic brain injury in mice.” PLoS ONE (2013): e71056.
α-MSH (11-13) (free acid) Preparation Products And Raw materials
Raw materials
Preparation Products
α-MSH (11-13) (free acid) Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Weimiao Import and Export Trade Co., Ltd. | +undefined19948166995 | sale01@hbweimiao.com | China | 73 | 58 |
Hebei Xunou new energy Technology Co., LTD | +undefined17531957005 | xunou8@hbxunou.com | China | 36 | 58 |
Sea Biological Co.,LTD | +86-13865152372 +86-13865152372 | tim@sea-biol.com | China | 46 | 58 |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10978 | 58 |
Hebei Xinsheng New Material Technology Co., LTD. | +86-16632316109 | xinshengkeji@xsmaterial.com | China | 1090 | 58 |
Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 994 | 58 |
Shijiazhuang Saixin Technology Co., Ltd. | +86-16632312509 +86-16632315022 | saixinkeji@aliyun.com | China | 90 | 58 |
Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 616 | 58 |
Sigma Audley | +86-18336680971 +86-18126314766 | nova@sh-teruiop.com | China | 496 | 58 |
Shanghai Affida new material science and technology center | +undefined15081010295 | admin@oudaxin.com | China | 114 | 58 |
View Lastest Price from α-MSH (11-13) (free acid) manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-07-08 | KPV
67727-97-3
|
US $0.00-0.00 / BOX | 1BOX | 99 | 50000KG/month | Shanghai Affida new material science and technology center | ||
2024-07-08 | KPV | US $27.00-23.00 / box | 3box | 99% | 1000 box | Hebei Xunou new energy Technology Co., LTD | ||
2024-06-19 | KPV
67727-97-3
|
US $50.00 / box | 1box | >99% | 20tons | Hong Kong Excellence Biotechnology Co., Ltd. |