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ChemicalBook >> CAS DataBase List >>11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE

11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE

11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE Structure
11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE structure
CAS No.
102394-31-0
Chemical Name:
11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE
Synonyms
AF-DX 116;Brn 4212983;(100158-38-1) otenzepad;ethyl)-7-piperidinyl)acetyl)-;Muscarinic acetylcholine receptor,Otenzepad,Inhibitor,mAChR,inhibit,memory;6h-pyrido(2,3-b)(1,4)benzodiazepin-6-one,5,11-dihydro-11-((2-((diethylamino)m;11-(2-(2-((Diethylamino)methyl)piperidin-1-yl)acetyl)-5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one;11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE;11-[2-[2-[(Diethylamino)methyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one;6H-Pyrido(2,3-B)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-((2-((diethylamino)methyl)-7-piperidinyl)acetyl)-
CBNumber:
CB1242627
Molecular Formula:
C24H31N5O2
Molecular Weight:
421.54
MDL Number:
MFCD00864743
MOL File:
102394-31-0.mol
MSDS File:
SDS
Last updated:2024-11-19 20:33:22
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11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE Properties

Boiling point 573.2±45.0 °C(Predicted)
Density 1.171
storage temp. room temp
solubility DMSO: soluble5mg/mL (clear solution; warmed)
pka 11.29±0.20(Predicted)
form powder
color white to beige
FDA UNII OM7J0XAL0S

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P233-P260-P261-P264-P271-P280-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
NFPA 704
0
1 0

11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0435 AF-DX 116 ≥98% (HPLC) 102394-31-0 5mg $109 2024-03-01 Buy
Sigma-Aldrich SML0435 AF-DX 116 ≥98% (HPLC) 102394-31-0 25mg $345 2024-03-01 Buy
Sigma-Aldrich 5.05821 AF-DX 116 - CAS 102394-31-0 - Calbiochem 102394-31-0 10MG $205 2022-05-15 Buy
Tocris 1105 AF-DX 116 ≥98%(HPLC) 102394-31-0 10 $171 2021-12-16 Buy
Tocris 1105 AF-DX 116 ≥98%(HPLC) 102394-31-0 50 $717 2021-12-16 Buy
Product number Packaging Price Buy
SML0435 5mg $109 Buy
SML0435 25mg $345 Buy
5.05821 10MG $205 Buy
1105 10 $171 Buy
1105 50 $717 Buy

11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE Chemical Properties,Uses,Production

Uses

AF-DX 116 has been used as an M2 muscarinic acetylcholine receptor (M2AChR) selective antagonist to study the influence of M2AChR in the regulation of both basal and carbachol-stimulated long-term potentiation at the dentate gyrus (DG-LTP) and pro-nerve growth factor (proNGF) secretion in hippocampal cells of young diabetic rats.

Definition

ChEBI: 11-[2-[2-(diethylaminomethyl)-1-piperidinyl]-1-oxoethyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one is a benzodiazepine.

Biological Activity

Selective M 2 muscarinic receptor antagonist. K i values are 64, 417, 786, 211 and 5130 nM for human recombinant M 2 , M 1 , M 3 , M 4 and M 5 muscarinic receptors, respectively.

Biochem/physiol Actions

AF-DX 116 raises blood pressure and heart rate in a rat model of hypotension induced by repeated cold stress. Thus, it may be used as a therapeutic for hypotension related to vagotonia type autonomic dysfunction.

storage

Room temperature

11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE Suppliers

Global( 55)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32957 60
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49374 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Alfa Chemistry 		Info@alfa-chemistry.com United States 24072 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15839 69
Ascent Scientific 4401179829988 customerservice@ascentscientific.co.uk United Kingdom 279 60
HangZhou YuHao Chemical Technology Co., Ltd. 0571-82693216 info@yuhaochemical.com China 2028 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51456 80
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
TargetMol Chemicals Inc. 		58
Alfa Chemistry 		58
J & K SCIENTIFIC LTD. 76
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Ascent Scientific 60
HangZhou YuHao Chemical Technology Co., Ltd. 58
Sigma-Aldrich 80

View Lastest Price from 11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Otenzepad pictures 2024-11-19 Otenzepad
102394-31-0
 US $39.00-133.00 / mg 99.81% 10g TargetMol Chemicals Inc.
  • Otenzepad pictures
  • Otenzepad
    102394-31-0
  • US $39.00-133.00 / mg
  • 99.81%
  • TargetMol Chemicals Inc.

11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE Spectrum

11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE(102394-31-0)1HNMR

102394-31-0(11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE)Related Search:

Hexamethyldisilazane CHEMBRDG-BB 4015189 DIMETHYL-PIPERIDIN-2-YLMETHYL-AMINE 1-ethylpiperidine-2-methylamine C-(1-METHYL-PIPERIDIN-2-YL)-METHYLAMINE
Methyl[(1-methylpiperidin-2-yl)methyl]amine 3-Amino-2-phenylamino-pyridine ETHYL[(1-METHYLPIPERIDIN-2-YL)METHYL]AMINE 5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one ETHYL[(1-ETHYLPIPERIDIN-2-YL)METHYL]AMINE
2-(2-methylpiperidin-1-yl)ethanamine 2-amino-N-(3-pyridinyl)benzamide (1-ETHYL-2-PIPERIDINYL)-N-METHYLMETHANAMINE 2-(2-DIETHYLAMINOETHYL)PIPERIDINE 11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE

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11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE AF-DX 116 6h-pyrido(2,3-b)(1,4)benzodiazepin-6-one,5,11-dihydro-11-((2-((diethylamino)m ethyl)-7-piperidinyl)acetyl)- 11-((2-((Diethylamino)methyl)-1-piperidinyl)acetyl)-5,11-dihydro-(6H)-pyrido[2.3-b][1.4]benzodiazepin-6-one 6H-Pyrido(2,3-B)(1,4)benzodiazepin-6-one, 11-((2-((diethylamino)methyl)-1-piperidinyl)acetyl)-5,11-dihydro- 6H-Pyrido(2,3-B)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-((2-((diethylamino)methyl)-7-piperidinyl)acetyl)- Brn 4212983 11-[2-[2-[(Diethylamino)methyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one 11-(2-(2-((Diethylamino)methyl)piperidin-1-yl)acetyl)-5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one (100158-38-1) otenzepad 6H-Pyrido[2,3-b][1,4]benzodiazepin-6-one, 11-[2-[2-[(diethylamino)methyl]-1-piperidinyl]acetyl]-5,11-dihydro- Muscarinic acetylcholine receptor,Otenzepad,Inhibitor,mAChR,inhibit,memory 102394-31-0 C24H31N5O2 Acetylcholine receptor Muscarinic