PROTEINASE 3 HUMAN PR3 AG (DONOR LEUKOCYTES)
- CAS No.
- Chemical Name:
- PROTEINASE 3 HUMAN PR3 AG (DONOR LEUKOCYTES)
- Synonyms
- PR3 Ag;Proteinase3 from human leukocytes;PROTEINASE 3 HUMAN PR3 AG (DONOR LEUKOCYTES)
- CBNumber:
- CB1245097
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD03458212
- MOL File:
- Mol file
SAFETY
Risk and Safety Statements
| Hazard Codes | B |
|---|---|
| WGK Germany | 3 |
PROTEINASE 3 HUMAN PR3 AG (DONOR LEUKOCYTES) Chemical Properties,Uses,Production
Uses
Proteinase 3 has been shown to be important in the pathogenesis of human emphysema. It has also been used in a study to investigate the liberation of the antibacterial and cytotoxic peptide LL-37 by cleavage of human cathelicidin hCAP-183.
General Description
Proteinase 3 (PR3) is mapped to human chromosome 19p13.3. Proteinase 3 is present majorly in azurophilic granules and belongs to neutrophil-derived proteases family. PR3 is a peripheral membrane protein and lacks transmembrane domain. It comprises of an unique interfacial binding site (IBS) and two amino acid clusters, one charged and one hydrophobic, for membrane association.
Biochem/physiol Actions
Proteinase 3 (PR-3) is a serine protease expressed in the granules of neutrophils and monocytes. Also known as myeloblastin and p29b, it degrades elastin and is associated with myeloid leukemia and Wegener′s granulomatosis.
PROTEINASE 3 HUMAN PR3 AG (DONOR LEUKOCYTES) Preparation Products And Raw materials
Raw materials
Preparation Products
PROTEINASE 3 HUMAN PR3 AG (DONOR LEUKOCYTES) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Riedel-de Haen AG | -- | United States | 6825 | 87 | |
| SIGMA-RBI | -- | Switzerland | 6913 | 91 |
| Supplier | Advantage |
|---|---|
| Riedel-de Haen AG | 87 |
| SIGMA-RBI | 91 |