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tesofensine

CAS No.
195875-84-4
Chemical Name:
tesofensine
Synonyms
Tesofensine-13C-d3;Tesofensine 0.5mg Tablets;Tesofensine 500mcg Tablets;(1R,2R,3S,5S)-3-(3,4-Dichlorophenyl)-2-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane;(1S,3S,4R,5R)-3-(3,4-dichlorophenyl)-4-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane;8-Azabicyclo[3.2.1]octane, 3-(3,4-dichlorophenyl)-2-(ethoxymethyl)-8-methyl-, (1R,2R,3S,5S)-
CBNumber:
CB12498844
Molecular Formula:
C17H23Cl2NO
Molecular Weight:
328.28
MDL Number:
MFCD25976398
MOL File:
195875-84-4.mol
Last updated:2024-11-04 20:04:50

tesofensine Properties

Boiling point 396.6±42.0 °C(Predicted)
Density 1.161±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 2 mg/mL,DMSO: 1 mg/mL,Ethanol: Slightly soluble,PBS (pH 7.2): 0.14 mg/mL
form A solid
pka 10.46±0.60(Predicted)
color White to off-white
Stability Hygroscopic
InChI InChI=1S/C17H23Cl2NO/c1-3-21-10-14-13(9-12-5-7-17(14)20(12)2)11-4-6-15(18)16(19)8-11/h4,6,8,12-14,17H,3,5,7,9-10H2,1-2H3/t12-,13+,14+,17+/m0/s1
InChIKey VCVWXKKWDOJNIT-ZOMKSWQUSA-N
SMILES [C@@]12([H])N(C)[C@@]([H])(CC1)C[C@H](C1=CC=C(Cl)C(Cl)=C1)[C@H]2COCC
FDA UNII BLH9UKX9V1

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501
NFPA 704
0
2 0

tesofensine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC T136500 Tesofensine 195875-84-4 1mg $305 2021-12-16 Buy
Product number Packaging Price Buy
T136500 1mg $305 Buy

tesofensine Chemical Properties,Uses,Production

Description

Tesofensine ((1R, 2R, 3S, 5S)-3-(3, 4-dichlorophenyl)-2-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane)) is an inhibitor of neuronal reuptake of dopamine, noradrenaline, and serotonin. Tesofensine was developed for the treatment of Alzheimer's and Parkinson's disease but lacked efficacy. Meta-analysis revealed that tesofensine (0.125–1.0 mg, once daily; oral) produced dose-dependent weight loss, and 32% of obese patients had ≥ 5% weight loss following 14 wk of treatment. Weight loss was accompanied by hypophagia, suggesting an appetite suppressant action[2].

History

Tesofensine is a dopamine, serotonin, and noradrenaline (triple) reuptake inhibitor originally developed by NeuroSearch for the treatment of Alzheimer's disease and Parkinson's disease. Development of the compound for these neurological indications was unsuccessful but significant weight loss was reported during the clinical trials in Parkinson's disease. Hence, tesofensine is now being developed by NeuroSearch for the treatment of obesity and type 2 diabetes[1].

Uses

Tesofensine, is a serotonin–noradrenaline–dopamine reuptake inhibitor from the phenyltropane family of drugs, which is currently in clinical development for the treatment of obesity.

References

[1] Dourish, C. J. Wilding and J. Halford. “Anti-obesity Drugs: From Animal Models to Clinical Efficacy.”Animal and Translational Models for CNS Drug Discovery 2008: 271-315.
[2] Vidya Narayanaswami, Linda P. Dwoskin. “Obesity: Current and potential pharmacotherapeutics and targets.” Pharmacology Therapeutics 170 (2017): Pages 116-147.

tesofensine Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 38)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Weimiao Import and Export Trade Co., Ltd.
+86-19948166995 +86-19948166995 sale01@hbweimiao.com China 76 58
Hebei Dangtong Import and export Co LTD
+86-13910575315 +86-13910575315 admin@hbdangtong.com China 1000 58
Shanghai Getian Industrial Co., LTD
+86-15373193816 +86-15373193816 mike@ge-tian.com China 269 58
Shandong Huizhihan Supply Chain Co., Ltd
+8613363081709 3957328362@qq.com China 249 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28172 58
AFINE CHEMICALS LIMITED
+86-0571-85134551 sales@afinechem.com China 15353 58
Alfa Chemistry
Info@alfa-chemistry.com United States 24072 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38632 58
Suzhou ARTK Medchem Co., Ltd.
+86-512-68323658 +86-18168183658 sales1@artkmedchem.com China 39004 58
SHANGHAI HOHANCE CHEMICAL CO.,LTD 021-31115312 18217084087 mary@hohance.com China 143 62

View Lastest Price from tesofensine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tesofensine pictures 2024-11-15 Tesofensine
195875-84-4
US $0.00-0.00 / BOX 1BOX 99.99% 1000 Shandong Huizhihan Supply Chain Co., Ltd
Tesofensine pictures 2024-10-28 Tesofensine
195875-84-4
US $954.00-1490.00 / mg 10g TargetMol Chemicals Inc.
tesofensine pictures 2024-10-24 tesofensine
195875-84-4
US $110.00-53520.00 / g 1g 99% 5Tons Hebei Dangtong Import and export Co LTD
  • Tesofensine pictures
  • Tesofensine
    195875-84-4
  • US $0.00-0.00 / BOX
  • 99.99%
  • Shandong Huizhihan Supply Chain Co., Ltd
  • Tesofensine pictures
  • Tesofensine
    195875-84-4
  • US $954.00-1490.00 / mg
  • TargetMol Chemicals Inc.
  • tesofensine pictures
  • tesofensine
    195875-84-4
  • US $110.00-53520.00 / g
  • 99%
  • Hebei Dangtong Import and export Co LTD
(1S,3S,4R,5R)-3-(3,4-dichlorophenyl)-4-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane (1R,2R,3S,5S)-3-(3,4-Dichlorophenyl)-2-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane Tesofensine-13C-d3 8-Azabicyclo[3.2.1]octane, 3-(3,4-dichlorophenyl)-2-(ethoxymethyl)-8-methyl-, (1R,2R,3S,5S)- Tesofensine 500mcg Tablets Tesofensine 0.5mg Tablets 195875-84-4